Searchable abstracts of presentations at key conferences in endocrinology

ea0026p73 | Endocrine tumours and neoplasia | ECE2011

68Ga-DOTATATE PET shows a better diagnostic performance than octreoscan in patients with neuroendocrine tumors

Faggiano Antongiulio , Aloi Luigi , Caraco Corradina , Ramundo Valeria , Severino Rosa , Lombardi Gaetano , Colao Annamaria , Lastoria Secondo

Background and objective: 111In-DPTA-Octreotide (Octreoscan) has limited spatial resolution and a somewhat lower receptor affinity of the radiopeptide compared to DOTATATE, a novel somatostatin analogue, which can be radiolabelled with 68Ga and adapted for PET imaging, resulting in an increased spatial resolution. The aim of this study was to evaluate the diagnostic performance of 68Ga-DOTATATE PET in patients with NET and to compare this tecni...

ea0026p274 | Pituitary | ECE2011

Recent changes in clinical presentation and therapeutic approach in MEN1-related pituitary adenomas

Ramundo Valeria , Severino Rosa , Milone Francesco , Lombardi Gaetano , Colao Annamaria , Faggiano Antongiulio

Background and objective: Pituitary adenomas (PAs) affect about half of the patients with multiple endocrine neoplasia type 1 (MEN1); in the most of cases PA is a PRL-oma and generally more aggressive than the sporadic form. The aim of this study is to evaluate the recent changes in clinical presentation and therapeutic approach of MEN1-related PAs.Patients and methods: The study population included 17 patients with MEN1-related PA followed-up between 19...

ea0026p530 | Bone/calcium/Vitamin D | ECE2011

Recent changes in clinical presentation and therapeutic approach of primary hyperparathyroidism in MEN1 patients

Severino Rosa , Ramundo Valeria , Milone Francesco , Lombardi Gaetano , Colao Annamaria , Faggiano Antongiulio

Introduction and aim: Primary hyperparathyroidism (PHP) is the most frequent endocrine abnormality in MEN1 affecting about 100% of cases and inducing severe bone and kidney complications. Although surgery represents the only curative approach in MEN1 PHP, novel drugs are now available to effectively control PHP. The objective of this study was to show the recent changes in clinical presentation and therapeutic approach in MEN1-related PHP occurred in the last years.<p clas...

ea0022p406 | Endocrine tumours &amp; neoplasia (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Clinical and prognostic implications of the genetic diagnosis of hereditary NET syndromes in asymptomatic patients

Faggiano Antongiulio , Ramundo Valeria , Milone Francesco , Severino Rosa , Lombardi Gaetano , Colao Annamaria

Context: Neuroendocrine tumors (NETs) are rare neoplasms, heterogeneous, with variable biological behaviour. NETs can be sporadic or they can arise in complex endocrine hereditary syndromes such as Multiple Endocrine Neoplasias (MEN), Familial Paragangliomatosis (FPGL), Neurofibromatosis type 1 (NF1), von Hippel-Lindau Disease (VHL), Tuberous Sclerosis (TSC) and Carney Complex (CC). By performing genetic screening, patients with hereditary NETs can be identified before the dev...

ea0022p475 | Female reproduction | ECE2010

Endothelial structure and function in young women with polycystic ovary syndrome: a 5 years follow-up study

Orio Francesco , Giallauria Francesco , Grieco Alessandra , Caggiano Chiara , Lombardi Gaetano , Caggiano Domenico , Palomba Stefano , Colao Annamaria

To date, studies focusing on long-term cardiovascular risk (CVR) of polycystic ovary syndrome (PCOS) women are not available, as well as longitudinal data regarding the endothelial structure and function.The aim of this observational study was to examine both endothelial structure and function in young women with PCOS at 5-year follow-up.Thirty PCOS women (age 22.2±2.5 years, mean±S.D.; BMI 22.4±2.1, k...

ea0022p476 | Female reproduction | ECE2010

Structured exercise training plus hypocaloric diet improves ovarian sensitivity to clomiphene citrate in polycystic ovary syndrome (PCOS) patients

Palomba Stefano , Giallauria Francesco , Falbo Angela , Russo Tiziana , Grieco Alessandra , Colao Annamaria , Lombardi Gaetano , Orio Francesco

Clomiphene citrate (CC) is the first-line therapy for inducing ovulation in infertile women with polycystic ovary syndrome (PCOS), but about 20% of them results un-responsive. Lifestyle modification programs are effective in restoring ovarian function and improving reproductive outcomes in PCOS patients.The aim of the present randomized controlled trial was to test the hypothesis that a very short-term intervention consisting in structured exercise train...

ea0020p561 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Glucose tolerance and somatostatin analogues treatment in acromegaly: a 12 month open, prospective study

Colao Annamaria , Auriemma Renata S , Savastano Silvia , Galdiero Mariano , Grasso Ludovica FS , Lombardi Gaetano , Pivonello Rosario

Objective: The impact of first-line somatostatin analogues (SSA) on glucose tolerance in acromegaly was investigated during a 10 year period.Patients: One hundred and twelve patients treated with depot SSA.Outcome measures: Primary outcome measures were fasting glucose levels. Data were analyzed according with baseline glucose tolerance and disease control.Results after 12 months SSA treatment: In the 63 pati...

ea0020p589 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Five year experience with GH replacement therapy on tumor occurrence or recurrence: one center study

Di Somma Carolina , Rota Francesca , Savanelli Maria Cristina , Lombardi Gaetano , Colao Annamaria

GH replacement is widely used in adults with hypopituitarism, but its effect on tumor occurrence and pituitary tumor recurrence is unknown. Furthermore, in literature there are scant with short follow-up time. The available data do not seem to suggest that rhGH replacement increased the incidence of regrowth of pituitary tumor and of cancer in adults with GHD, provided that IGF-1 concentrations remain within the normal range for age.The aim of our study ...

ea0016p287 | Endocrine tumours | ECE2008

The role of 2-[18F]-fluoro-2-deoxy-D-glucose positron emission tomography (FDG/PET-CT) in the follow-up of differentiated thyroid cancer (DTC)

Pagano Loredana , Klain Michele , Pulcrano Melania , Ippolito Serena , Lombardi Gaetano , Salvatore Marco , Biondi Bernadette

Aim: To address the role of FDG/PET-CT in the follow-up of DTC.Methods: About 110 consecutive patients (86 female, 24 male, mean age 45±13 years), with DTC were selected between 1999 and 2006. All patients underwent total thyroidectomy, radioiodine ablation and had undetectable serum thyroglobulin (Tg) during L-T4 suppressive therapy and negative serum TgAb. The follow-up included a yearly clinical examination with n...

ea0014oc3.7 | Endocrine tumors &amp; neoplasia | ECE2007

Fasting insulin levels are predictors of colonic lesions in patients with acromegaly: an observational, open, prospective study in 189 patients

Colao Annamaria , Pivonello Rosario , Galdiero Mariano , Auriemma Renata S. , Ferone Diego , Marzullo Paolo , Lombardi Gaetano

Elevated insulin levels are correlated with colonic adenomas and carcinomas in the general population. Patients with acromegaly are considered at high risk to develop colonic lesions and have a high insulin levels. To evaluate the role of insulin levels on colonic polyps (hyperplastic, adenomatous, single or synchronous) or adenocarcinoma in acromegaly we designed this analytical, observational, open, prospective, study enrolling 189 patients (100 women, 89 men, age 20–82...