Searchable abstracts of presentations at key conferences in endocrinology

ea0035p286 | Clinical case reports Thyroid/Others | ECE2014

One month-Tadalafil 5 mg once daily administration improves clinical and ultrasound parameters of chronic pelvic pain syndrome/lower urinary tract symptoms

Lotti Francesco , Corona Giovanni , Maggi Mario

Introduction: Tadalafil 5 mg once daily (T5od) has been recently approved by the Food and Drug Administration for the treatment of lower urinary tract symptoms (LUTS), along with erectile dysfunction (ED). Recent pooled data analyses demonstrated that T5od–International Prostate Symptom Score related improvements were significant regardless of confounders. In addition, PDE5 inhibitors exert a positive effect on ejaculatory latency. We assessed the clinical outcome of 30 d...

ea0041ep714 | Male Reproduction | ECE2016

Positive effect of FSH therapy on quantitative and functional sperm parameters in idiopathic infertile men

Krausz Csilla , Casamonti Elena , Vinci Sabrina , Fino Maria Grazia , Brilli Sara , Lotti Francesco , Serra Emmanuele

Follicle-stimulating hormone (FSH) therapy is a potential treatment option in idiopathic infertile men with normal FSH levels. In fact, a recent Cochrane meta-analysis showed that FSH treatment of men affected by idiopathic oligozoospermia significantly improves pregnancy rate. Hyaluronic acid (HA) binding capacity of spermatozoa is considered a marker of functional competency, consequently the evaluation of the percentage of HA bound spermatozoa in the ejaculate can serve as ...

ea0035p207 | Cardiovascular Endocrinology & Lipid Metabolism | ECE2014

Flaccid penile acceleration as a marker of cardiovascular risk in men without classical risk factors

Rastrelli Giulia , Corona Giovanni , Lotti Francesco , Aversa Antonio , Bartolini Marco , Mancini Mario , Mannucci Edoardo , Maggi Mario

Introduction: Conventional cardiovascular (CV) risk factors identify only half of subjects with incident major adverse CV events (MACE). Hence new markers are needed in high CV risk subjects, as those with erectile dysfunction (ED). A role for dynamic peak systolic velocity (D-PSV) at penile color Doppler ultrasound (PCDU) has been suggested, but it is operator-dependent and time-consuming. Flaccid penile acceleration (FPA) is a PCDU parameter that reflects PSV, the systolic r...

ea0035p693 | Male reproduction | ECE2014

Seminal, ultrasound and psychobiological parameters correlate with metabolic syndrome in male members of infertile couples

Lotti Francesco , Corona Giovanni , Degl'Innocenti Selene , Filimberti Erminio , Scognamiglio Vittoria , Vignozzi Linda , Forti Gianni , Maggi Mario

Introduction: Metabolic syndrome (MetS) is a diagnostic category which identifies subjects at high risk for diabetes and cardiovascular diseases, erectile dysfunction (ED) and male hypogonadism. However, MetS impact on male infertility has been poorly studied. We systematically evaluated possible associations between MetS and clinical characteristics in men with couple infertility.Methods: Out of 367 consecutive subjects, 351 men (36.0±8.0 years) wi...

ea0035p704 | Male reproduction | ECE2014

Current smoking is associated with lower ejaculate and seminal vesicles volume but higher testosterone levels compared to no-smoking in males of infertile couples

Lotti Francesco , Corona Giovanni , Maseroli Elisa , Rossi Matteo , Forti Gianni , Maggi Mario

Introduction: Smoking habit has always been considered to exert a detrimental effect on male reproductive health. However, several studies do not clearly demonstrate a negative effect of smoke on semen parameters. In addition, the effect of smoke on male genital tract has been poorly studied by ultrasound (US). We evaluated the correlations of smoking with seminal and US characteristics in males of infertile couples. Methods. A consecutive series of 426 men was systematically ...

ea0035p706 | Male reproduction | ECE2014

Relationship of testis size and LH levels with incidence of major adverse cardiovascular events in older men with sexual dysfunction

Rastrelli Giulia , Corona Giovanni , Lotti Francesco , Boddi Valentina , Mannucci Edoardo , Maggi Mario

Introduction: Measurement of testis volume (TV) is a reliable clinical procedure that predicts reproductive fitness. However, the role of TV in overall and cardiovascular (CV) fitness has never been studied.Aim: The study aims to analyze the clinical correlates of TV in patients with sexual dysfunction (SD) and to verify the value of this parameter and its determinants (i.e., luteinizing hormone (LH) levels) in predicting major adverse CV events (MACE).<...

ea0032p653 | Male reproduction | ECE2013

Metabolic syndrome correlates with prostate volume and biochemical and ultrasound signs of prostate inflammation in male members of infertile couples

Lotti Francesco , Corona Giovanni , Vignozzi Linda , Rossi Matteo , Maseroli Elisa , Gacci Mauro , Forti Gianni , Maggi Mario

Introduction: The impact of metabolic syndrome (MetS) on male infertility has been poorly studied. We recently reported that MetS is associated with hypogonadism, poor sperm morphology and testis ultrasound inhomogeneity. However, the possible associations between MetS and prostate-related symptoms and signs are still lacking.Methods: Out of 351 subjects without genetic abnormalities previously evaluated for couple infertility clinically and by scrotal u...

ea0016p616 | Reproduction | ECE2008

Estimated cardiovascular risk and arteriogenic erectile dysfunction

Corona Giovanni , Mannucci Edoardo , Fisher Alessandra , Lotti Francesco , Balercia Giancarlo , Petrone Luisa , Forti Gianni , Maggi Mario

Objectives: Recommending general dynamic penile color doppler ultrasound (D-PCDU) screening in patients with erectile dysfunction (ED) has been questioned due to an inadequate cost-benefit ratio. The aim of the present study is to asses the validity of different risk scores in the identification of patients being screened for arteriogenic ED at D-PCDU.Design and methods: A consecutive series of 738 (mean age 53.6±9.2 years) patients with ED was stud...

ea0035p692 | Male reproduction | ECE2014

Clinical implications of measuring prolactin levels in males of infertile couples

Lotti Francesco , Corona Giovanni , Maseroli Elisa , Rossi Matteo , Silverii Antonio , Degl'Innocenti Selene , Rastrelli Giulia , Forti Gianni , Maggi Mario

Introduction: Although in females of infertile couples abnormal PRL has a definitive role in the medical flow-chart, its role in males is less clear. Animal models suggest that PRL does not play a major role in male reproduction, although its trophic action on male accessory glands was often observed. Studies in humans are scanty. We systematically evaluated possible clinical and ultrasound correlates of PRL in males of infertile couples.Methods: Out of ...

ea0035p694 | Male reproduction | ECE2014

Seminal, clinical and color-Doppler ultrasound correlations of prostatitis-like symptoms in males of infertile couples

Lotti Francesco , Corona Giovanni , Mondaini Nicola , Maseroli Elisa , Rossi Matteo , Filimberti Erminio , Noci Ivo , Forti Gianni , Maggi Mario

Introduction: ‘Prostatitis-like symptoms’ (PLS) are a cluster of bothersome conditions defined as ‘perineal and/or ejaculatory pain or discomfort and National Institutes of Health-Chronic Prostatitis Symptom Index (NIH-CPSI) pain subdomain score ≥4’ (Nickel’s criteria). PLS may originate from the prostate or from other portions of the male genital tract. Although PLS could be associated with ‘prostatitis’, they should not be confused. T...