Searchable abstracts of presentations at key conferences in endocrinology

ea0063p866 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

Primary adrenal lymphoma: a rare cause of adrenal insufficiency

Maciel Joana , Simoes Helder

Background: Primary adrenal Non Hodgkin Lymphoma (NHL) accounts for less than 1% of all NHL cases. Among them, Diffuse Large B Cell Lymphomas (DLBCL) are the most commonly identified. Seventy percent of cases are bilateral and adrenal insufficiency usually occurs. Here we describe a case of a DLBCL with bilateral adrenal involvement and adrenal insufficiency.Clinical case: A 68 years male with a personal history of malaria, asthma, hypertension and chole...

ea0075t05 | Thyroid | EYES2021

An unusual case of a solitary adrenal metastasis of thyroid carcinoma

Maciel Joana , Vilar Helena , Leite Valeriano

Backgroud: Distant metastases from papillary thyroid cancer (PTC) are infrequent and associated with poor prognosis. Adrenal metastatic lesions in this setting are rare, generally associated with lung and skeletal metastases. There have been few reported cases of isolated adrenal metastases from thyroid carcinoma. Here we report a patient with a PTC who developed a large and solitary adrenal metastasis.Case Presentation: A 68-year-old men was submitted i...

ea0070ep10 | Adrenal and Cardiovascular Endocrinology | ECE2020

Malignant neuroblastoma mimicking a metastatic paraganglioma – case report

Maciel Joana , Teresa Alexandre Maria , Simões Helder

Background: Neuroblastomas are malignant tumors that arise from sympathetic plexus or adrenal medulla. Their clinical behavior can range from spontaneous regression to aggressive disease. Like paragangliomas, they have the capacity to secrete catecholamines and to express somatostatin receptors, which is important for diagnostic and treatment purposes. However, the differential diagnosis with paraganglioma can be challenging. We present a case of a catecholamine-producing tumo...

ea0056ep23 | Adrenal and Neuroendocrine Tumours | ECE2018

Intestinal pseudo-obstruction as a fatal complication of a malignant hereditary paraganglioma: A case report

Maciel Joana , Donato Sara , Simoes Helder , Leite Valeriano

Background: Familial paraganglioma type 1 syndrome is a hereditary form of paraganglioma due to an autosomal dominant, paternally inherited, germinal mutation in the SDHD subunit. Intestinal pseudo-obstruction is a rare complication of secretory PGL. We present a case of a patient with a malignant PGL syndrome type 1 who developed intestinal pseudo-obstruction.Clinical case: The patient was a Dutch male, aged 39 years, carrier of a germinal mutation in e...

ea0081p496 | Thyroid | ECE2022

Outcomes of low-risk differentiated thyroid cancer submitted to radioactive iodine ablation - a comparative analysis in a single tertiary centre

Ivo Catarina , Amaral Sara , Raposo Nuno , Maciel Joana , Simoes Pereira Joana , Vilar Helena , Leite Valeriano

Introduction: The update of 2015 American Thyroid Association (ATA) guidelines recommend that radioactive iodine (RAI) ablation therapy should be used in line with patients’ risk stratification. However, there is no consensus on benefits of post-operative RAI ablation in patients with low risk differentiated thyroid cancer (DTC). The aim of this study is to compare the outcomes of patients with low risk DCT submitted to RAI ablation with those who were not.<p class="a...

ea0081p497 | Thyroid | ECE2022

Impact of 2015 ATA guidelines in 131I prescription in low-risk DTC

Amaral Sara , Ivo Catarina , Cordeiro Raposo Nuno , Maciel Joana , Simoes-Pereira Joana , Vilar Helena , Leite Valeriano

Background: To minimize potential harm from overtreatment of low-risk thyroid cancers, the 2015 American Thyroid Association (ATA) Guidelines recommend that radioactive iodine (RAI) ablation should not be routinely used in low-risk differentiated thyroid carcinoma (DTC). The present study aims to evaluate trends in RAI therapy in a tertiary center after the update of these Guidelines.Methods: Data from patients followed in a tertiary center with low-risk...

ea0067gp15 | Poster Presentations | EYES2019

Challenges in the management of severe constipation due to metastatic paraganglioma

Figueiredo Ana Abrantes , Maciel Joana , Cavaco Daniela , Donato Sara , Simoes Helder , Simoes-Pereira Joana , Leite Valeriano

Background: Pheochromocytoma and paragangliomas (PPGLs) are rare disorders with a rate of malignancy of 10–20%. The control of the hormonal symptoms caused by the catecholaminergic burden in the metastatic disease is a challenging task. Hypertension is the most recognized feature, but gastrointestinal manifestations can be hard to manage and life-threatening.Cases Presentation: We present three cases of metastatic PPGLs who developed intestinal pseu...

ea0092ps1-01-04 | Cancer | ETA2023

Papillary thyroid carcinoma from a thyroglossal duct cyst: a rare association

Lopes Valentim , Brito Patricia , Lages Adriana , Maciel Joana , Pereira Ricardo , Machado Catarina

Introduction: Thyroglossal duct cysts (TDC) are a very frequent congenital neck mass and are mostly benign. Papillary thyroid carcinoma (PTC) originating from a TDC represents an infrequent finding. Usually, the diagnosis is only made postoperatively after cyst’s excision.Case report: A 38-years old female patient was referred to the Endocrinology department due to Graves’ disease. She had been treated with antithyroid drugs for 18 months witho...

ea0084ps3-14-132 | Thyroid Cancer CLINICAL 2 | ETA2022

Efficacy and safety of lenvatinib in a cohort of well-differentiated advanced thyroid carcinomas

Damasio Ines , Maciel Joana , Figueiredo Ana , Simoes Helder , Nunes da Silva Tiago , Simoes-Pereira Joana , Horta Mariana , Santos Rita , Donato Sara , Leite Valeriano

Introduction: Treatment of differentiated thyroid carcinoma (DTC) remains a challenge in the setting of locally advanced or metastatic disease refractory to radiodine (RAI) therapy. SELECT trial demonstrated that Lenvatinib improved progression free survival (PFS) comparing to placebo.Objective: Our aim is to report the efficacy and safety of lenvatinib in our population with aggressive DTC.Methods: We retrospectively reviewed the ...

ea0070aep620 | Pituitary and Neuroendocrinology | ECE2020

Growth hormone deficiency in childhood acute lymphoblastic leukemia survivors – should systematic stimulation test be performed in all irradiated children?

Damasio Ines , Cavaco Daniela , Maciel Joana , Dias Daniela , Donato Sara , Pinheiro Sara , Figueiredo Ana , Simões-Pereira Joana , Pereira Conceiçao

Introduction: The combination of chemotherapy with prophylatic cranial radiotherapy (C-RT) allowed the improvement of survival rates of pediatric acute lymphoblastic leukemia (ALL) survivors while putting them at risk of develeping long-term endocrine deficiencies, like growth hormone deficiency (GHD).Current evidence suggests that the prevalence of GHD in children treated with radiation doses ≥ 30–50 Gy for non-pituitary brain tumors is...