Searchable abstracts of presentations at key conferences in endocrinology

ea0090ep699 | Pituitary and Neuroendocrinology | ECE2023

Pathologic characteristics of somatotroph pituitary tumors – an observational single-center study

Tomasik Agnieszka , Stelmachowska-Banaś Maria , Maksymowicz Maria , Czajka-Oraniec Izabella , Dorota Raczkiewicz , Zgliczyński Wojciech

Background: The first-line treatment in acromegaly is transsphenoidal adenomectomy of GH-secreting pituitary tumor. Pathologic evaluation of postoperative tissue is an essential part of patient’s assessment.Aim: The aim of this study was to analyse pathologic characteristics of pituitary tumors in patients with acromegaly.Patients and methods: One hundred twenty patients with acromegaly after at least one pituitary surgery tre...

ea0081ep657 | Pituitary and Neuroendocrinology | ECE2022

Pathomorphological markers of somatotroph neuroendocrine tumors predicting the treatment outcome in acromegaly

Tomasik Agnieszka , Stelmachowska-Banaś Maria , Maksymowicz Maria , Czajka-Oraniec Izabella , Raczkiewicz Dorota , Zieliński Grzegorz , Kunicki Jacek , Zgliczyński Wojciech

Background: Transsphenoidal adenomectomy of GH-secreting pituitary tumour is a first-line treatment of acromegaly. Pharmacological treatment is recommended if surgery did not lead to disease remission. Pathological assessment of postoperative tissue provides clinicians with valuable information on the disease course.Aim: The aim of this study was to assess whether clinical, imaging, and pathological characteristics can predict surgical remission and resp...

ea0035p229 | Clinical case reports Pituitary/Adrenal | ECE2014

A case of hypopituitarism caused by lung cancer metastasis to the pituitary

Kaluzny Marcin , Bolanowski Marek , Zielinski Grzegorz , Piesiak Pawel , Maksymowicz Maria

Pituitary tumor is a rare endocrine disorder. In the majority of cases, they are secreting prolactin and/or GH. Pituitary metastatic tumors are localized more often in the nervous than adenomatous hypophysis. Lung, breast and large intestine cancers metastases are found in the pituitary in the most cases. They cause hypopituitarism and local complications. The most often complications found are an optic nerve chiasm pressure or infiltration with a visual field loss, cavernous ...

ea0035p942 | Pituitary Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2014

Surgical treatment of ACTH-secreting pituitary adenomas in nelson syndrome

Zielinski Grzegorz , Maksymowicz Maria , Witek Przemyslaw , Koziarski Andrzej

Nelson’s syndrome (NS) is a rare clinical syndrome of an enlarging, aggresive corticotroph pituitary adenoma that can occur following bilateral adrenalectomy performed in the treatment of CD.The aim of this work is the evaluation of the early and long-term results of the microsurgery in a single surgeon’s series of patients with NSDuring the period from January 2000 to December 2005 - ten patients with NS have been operat...

ea0099p336 | Pituitary and Neuroendocrinology | ECE2024

Evaluation of new prognostic clinicopathological classification of pituitary adenomas proposed by trouillas et al. in patients with giant pituitary adenomas

Buchalska Barbara , Bonicki Wiesław , Maksymowicz Maria , Kunicki Jacek

Introduction: In 2013 Trouillas et al. reported a new prognostic clinicopathological classification of pituitary adenomas. This classification analyses the impact of the intensity of proliferation and invasiveness of the tumor on patients’ prognosis. The aim of the study was to review this new classification in giant pituitary adenomas (GPAs) treated with endoscopic transsphenoidal approach.Material and methods: The study is a retrospective...

ea0099p343 | Pituitary and Neuroendocrinology | ECE2024

Comparative analysis of giant and ‘nearly giant’ pituitary adenomas

Buchalska Barbara , Bonicki Wiesław , Maksymowicz Maria , Kunicki Jacek

Introduction: Giant pituitary adenomas (GPAs) are traditionally defined as the tumors with the greatest diameter at or above 40 mm. However, some clinical series of GPAs include tumors with maximal diameter of 35 to 40 mm, and those tumors can be named ‘nearly giant’ pituitary adenomas (nearly GPAs). The treatment of GPAs is challenging and has a higher risk of complications due to the size and complex anatomical relations. This study was conducted to compare GPAs an...

ea0081p647 | Endocrine-Related Cancer | ECE2022

Ectopic cushing’s syndrome due to thymic neuroendocrine tumour - a case report

Dzialach Lukasz , Wojciechowska-Luzniak Agnieszka , Migda Anna , Maksymowicz Maria , Witek Przemysław

Introduction: Ectopic Cushing’s syndrome (ECS) is a rare endocrine condition caused by corticotrophin (ACTH) hypersecretion of nonpituitary neoplasms. Thymic neuroendocrine tumours (NETs) account for about 5-10% of ECS cases, typically with aggressive clinical course.Case Report: A 31-year-old previously healthy female presented to the emergency department with a 3-week history of fatigue, muscle weakness, headaches and generalized swelling. Physica...

ea0081p421 | Pituitary and Neuroendocrinology | ECE2022

Efficacy of methotrexate in the treatment of isolated, steroid-resistant sarcoidosis of the hypothalamic-pituitary system

Kuca Pawel , Wojciechowska-Luzniak Agnieszka , Dzalach Lukasz , Migda Anna , Zielinski Grzegorz , Maksymowicz Maria , Witek Przemyslaw

Isolated sarcoidosis of the hypothalamic-pituitary system is a very rare form of neurosarcoidosis. It usually leads to secondary damage to endocrine function, resulting in hypopituitarism and diabetes insipidus. A 32-year-old male patient with progressive deterioration of his general condition, weakness, polyuria, dizziness and visual field disturbances was admitted to the Department of Endocrinology for the diagnosis of a tumor in the hypothalamic-pituitary region. MRI showed...

ea0063p1054 | Pituitary and Neuroendocrinology 3 | ECE2019

Prolactinomas in women: clinical, neuroradiological and pathological predictive factors for efficacy of transphenoidal surgery

Witek Przemyslaw , Ozdarski Marcin , Maksymowicz Maria , Styk Andrzej , Szamotulska Katarzyna , Zielinski Grzegorz

Background: The treatment of choice in prolactinomas are dopamine agonists, with surgery reserved for cases refractory to or poorly tolerant of pharmacotherapy. Little is known on the associations between clinical, neuroradiological and pathological features influencing the efficacy of transphenoidal surgery.The Aim: To evaluate clinical, neuroradiological and neuropathological aspects of surgically treated prolactinomas in women, with a particular empha...

ea0041ep250 | Clinical case reports - Pituitary/Adrenal | ECE2016

Capecitabine and temozolomide (CAPTEM) treatment of atypical macrocorticotropinoma in a patient with Nelson’s syndrome

Kurowska Maria , Malicka Joanna , Tarach Jerzy S , Zielinski Grzegorz , Maksymowicz Maria

Introduction: Atypical pituitary adenomas are often characterized by rapid growth and massive invasion of the surrounding structures. Usually, they are associated with poor prognosis and high recurrence rate due to resistance to conventional therapies. When surgery and radiation are ineffective, alternative therapies remain the last line treatment. Lately, a novel chemotherapy with capecitabine and temozolomide was proposed as a highly effective and extending the life of the p...