Searchable abstracts of presentations at key conferences in endocrinology

ea0077p253 | Thyroid | SFEBES2021

A case of Pituitary hyperplasia in patient with Graves’ disease over treated with carbimazole lead to severe hypothyroidism

Abouglila Kamal , Mamoojee Yaasir

Pituitary hyperplasia is a relatively common condition that occurs in both physiological and pathological states. Pregnancy is the most common condition associated with physiological pituitary enlargement, associated primarily with lactotroph hyperplasia. Pathological hyperplasia has been shown to be associated with end organ insufficiency from primary gonadal insufficiency, primary adrenal insufficiency, and primary hypothyroidism. We present the case of a 33-year-old male wi...

ea0038p421 | Steroids | SFEBES2015

Iatrogenic Cushing’s syndrome secondary to combined oral contraceptive pill in a patient with congenital adrenal hyperplasia

Artham Satish , Mamoojee Yaasir , Ashwell Simon

Introduction: Congenital Adrenal Hyperplasia (CAH) is a rare genetic disorder characterised by deficiency of cortisol and/or mineralocorticoid hormones with over production of sex steroids. 21-hydroxylase deficiency is the commonest cause of CAH accounting for 95% of cases. Severe form of classic CAH occurs in 1 in 15 000 live births.Case report: A 30 year old women with CAH diagnosed at birth was on replacement with hydrocortisone and fludrocortisone. S...

ea0038p425 | Steroids | SFEBES2015

Primary testicular lymphoma with bilateral adrenal masses and adrenal insufficiency

Artham Satish , Mamoojee Yaasir , Nag Sath

Introduction: Primary testicular lymphoma is very rare and constitutes about 2% of all extra nodal lymphomas, mostly in men above the age of 60. Bilateral adrenal masses could be due to metastatic disease, congenital adrenal hyperplasia, bilateral macro-nodular hyperplasia, adrenal adenomas, lymphomas, infiltrative diseases, amyloidosis and infections like tuberculosis. Metastasis occurs most commonly from lung, bowel, breast and pancreatic cancer. Metastasis from lymphomas is...

ea0073aep491 | Pituitary and Neuroendocrinology | ECE2021

The role of cannulated prolactin test in females of reproductive age presenting with isolated mild persistent hyperprolactinaemia on random sampling

Gad Hady , Mamoojee Yaasir , James Andy

IntroductionCurrent guidelines recommend a single elevated prolactin measurement drawn without excessive venepuncture stress as sufficient for diagnosing hyperprolactinaemia. However, previous studies have demonstrated that the cannulated prolactin test is more reliable at eliminating stress-induced hyperprolactinaemia, thus avoiding unnecessary additional investigations. We routinely perform morning serial prolactin sampling immediately after brachial v...

ea0073aep523 | Pituitary and Neuroendocrinology | ECE2021

Biliary ultrasound surveillance in patients with acromegaly treated with somatostatin receptor ligands: A large tertiary centre experience

Panagiotou Grigorios , Mamoojee Yaasir , James Andy

BackgroundSomatostatin receptor ligands (SRL) are commonly used in patients with acromegaly to control insulin growth factor 1 (IGF1) concentrations. Biliary sludge or gallstone formation are well-recognised biliary adverse events (BAE) from SRL therapy. Our current practice is to routinely monitor patients with acromegaly on SRL with ultrasound scanning (USS). Once BAE are detected, ursodeoxycholic acid (UDCA) therapy is initiated.<p class="abstext"...

ea0077lb22 | Late Breaking | SFEBES2021

Effect of Enzalutamide on cortisol dynamics

Abouzaid Mona , Holliday Rachel , Boot Chris , Quinton Richard , Mamoojee Yaasir

Background: Enzalutamide is a next-generation androgen receptor (AR) antagonist, used as a daily oral agent, in the treatment of castration-resistant prostate cancer. Its suppression of 11β-hydroxysteroid dehydrogenase-2 enzyme has been reported in the literature, leading to hypertension through a relative increase in cortisol concentration at the level of the mineralocorticoid receptors. Enzalutamide is also known to be a potent inducer of drug metabolising enzymes (cyto...

ea0081ep664 | Pituitary and Neuroendocrinology | ECE2022

Peak cortisol level on synacthen stimulation test in cushing’s disease

Ali Rashid Razan , Boot Christopher S , James Andy , Mamoojee Yaasir

Background: Diagnostic work-up for Cushing ’s syndrome (CS) can be challenging, with variable performance characteristics on screening tests. We were recently referred a young female patient with Cushing’s disease (CD) due to a microadenoma. She presented with a seizure and initial biochemical work-up included a Synacthen stimulation test (SST). Her peak cortisol rose to over 1,000 nmol/l. Exaggerated response during SST is expected in hyperestrogenic states due to e...

ea0082wa9 | Workshop A: Disorders of the hypothalamus and pituitary | SFEEU2022

Usefulness of desmopressin stimulation test in ACTH dependent Cushing’s syndrome in a young patient with no obvious pituitary lesion

Ali Mudassir , Ahmed Razi , Woods David , Mamoojee Yaasir

A 41 year-old male was referred urgently from secondary care with high suspicion of Cushing’s syndrome. His past medical history included psychosis and bipolar disorder, previous low impact foot fractures, rib fractures on coughing and spinal wedge fractures on X-ray, all within the last 5 years. He was taking quetiapine 300 mg modified-release and amitriptyline 10 mg daily, and tramadol 50 mg as needed. The patient reported decreasing mobility with increasing back pain, ...

ea0062p05 | Poster Presentations | EU2019

A rare cause of hyponatraemia

Javaid Usman , Mamoojee Yaasir , Leech Nicola , James Andy

Case history: We describe a case of 35 year old female who presented with abdominal pain, nausea and lower backache. She was initially treated with Trimethoprim for a urinary tract infection. 5 days later, she re-attended hospital with feeling more unwell, ongoing lower abdominal pain and vomiting. On examination, she was haemodynamically stable. She had suprapubic tenderness on abdominal palpation, and the rest of her systemic examination was normal.Inv...

ea0044p62 | Clinical biochemistry | SFEBES2016

Burden of major sodium and calcium abnormalities in the non-ITU adult inpatient population of a large two-site university hospital

Jones Philip , Mamoojee Yaasir , Neely Dermot , Quinton Richard

Background and aims: Electrolyte imbalance is common among hospital inpatients, reflecting severity of underlying illness, but also independently contributing to excess morbidity and mortality. However, studies have largely been retrospective, with incomplete data capture. We prospectively evaluated the prevalence of major Na and Ca disorders among inpatients at the Newcastle-upon-Tyne Hospitals.Method: With approval of the Information Guardian, we used ...