Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep188 | Endocrine tumours and neoplasia | ECE2017

An elevated chromogranin A: is it always a tumor progression?-case report

Bursuc Anamaria , Daniela Belceanu Alina , Armasu Ioana , Tirnovan Mirela , Manolachie Adina , Crumpei Felicia , Ciobanu Delia , Leustean Letitia , Vulpoi Carmen

Introduction: Pancreatic neuroendocrine tumors (PNET) are rare, with an incidence of 1/100,000/year. Chromogranin A (CgA) is the most valuable marker in the diagnosis and monitoring of PNET. One of the disadvantages is its low specificity and the existence of a number of processes leading to an increase in its concentration, which often results in confusion and diagnostic difficulties.Case report: We present a 44-years-old female patient...

ea0049ep1360 | Thyroid (non-cancer) | ECE2017

Mirela Tirnovan1, Anamaria Bursuc1, Alina Daniela Belceanu1, Adina Manolachie1, Ioana Armasu1, Iulia Crumpei1, Georgiana Constantinescu1, Luminita Apostu2, Carmen Vulpoi1

Tirnovan Mirela , Bursuc Anamaria , Belceanu Alina Daniela , Armasu Ioana , Crumpei Iulia , Manolachie Adina , Apostu Luminita , Vulpoi Carmen

Introduction: Many causes of malabsorbtion of levothyroxine (LT4) in patients with hypothyroidism have been thoroughly described in literature. Pseudomalabsorption, poor compliance of the patient is most common cause of failure of LT4 and/or liothyronine (LT3) treatment.Case report: 27 years old woman, normopondeal, presented from the age of 11 years for short stature. Further investigations found pluritrope pituitary insufficiency ...

ea0037ep81 | Adrenal cortex | ECE2015

Acute adrenal insufficiency as a first sign of metastatic pulmonary carcinoma

Manolachie Adina , Volovat Constantin , Grigorescu Cristina , Botnariu Gina Eosefina , Gafton Bogdan , Armasu Ioana , Leustean Letitia , Vulpoi Carmen

Introduction: Adrenal glands are common sites for secondary lesions derived from malignant tumours (lymphoma, melanoma, renal, breast, colon, and bronchopulmonary cancer). Patients with adrenal secondary lesions are typically asymptomatic but 1% may present with adrenal insufficiency as a first manifestation. We report the cases of two males with lung adenocarcinoma, first presented with acute adrenal insufficiency.Cases presentation: Case 1: LC, 65 year...

ea0037ep824 | Pituitary: clinical | ECE2015

A rare case of GH deficiency: mucolipidoses type II/III

Braha Elena , Armasu Ioana , Rusu Cristina , Raileanu Daniela , Manolachie Adina , Constantinescu Georgiana , Puiu Mirela , Stefan Roxana , Vulpoi Carmen

Introduction: Mucolipidoses II/III (ML) are rare autosomal recessive lysosomal storage disorders (incidence: 1/325 000 live births). They have overlapping clinical phenotypes with mucopolysaccharidosis disorders and include growth retardation, facial dysmorphism, skeletal abnormalities, respiratory and heart diseases, hepatosplenomegaly and abdominal hernias. There is no specific treatment and the management has been limited to supportive care.Case prese...

ea0037ep1301 | Clinical Cases–Thyroid/Other | ECE2015

Late onset of a rare autoimmune association: coeliac disease and Hashimoto's thyroiditis: hormonal and metabolic implications

Puiu Mirela , Popa Radu , Gologan Elena , Crumpei Felicia , Armasu Ioana , Vasiliu Ioana , Manolachie Adina , Preda Cristina , Vulpoi Carmen

Introduction: Several autoimmune determinations have been reported in association with autoimmune thyroidits (AIT). While the classical correlations with other endocrine or general autoimmune diseases like pernicious anemia or vitiligo are frequent and well defined, there are fewer data on other rarer associations, as with celiac disease (CD). In the absence of typical clinical symptoms this association may be overlooked, as in the case we present.Case p...

ea0037ep1312 | Clinical Cases–Thyroid/Other | ECE2015

A rare association: primary hyperparathyroidism and thyroid papillary carcinoma: case report

Zmau George-Sebastian , Preda Cristina , Stefanescu Cipriana , Danila Radu , Ciobanu Delia , Crumpei Iulia , Belceanu Alina Daniela , Manolachie Adina , Vulpoi Carmen

Introduction: Although, the relationship between pathological process of the parathyroid and thyroid is common, concurrence of primary hyperparathyroidism (pHPT) and papillary thyroid carcinoma (PTC) is extremely rare, probably because, unlike with medullary thyroid cancer, they have not a common embryologic origin. We present a case with this uncommon association.Case report: A 67-year-old woman with multinodular goitre was addressed in endocrinology fo...

ea0037ep1343 | Clinical Cases–Thyroid/Other | ECE2015

Concomitance of pancreatic and neuroendocrine breast tumour – simple coincidence or not?

Crumpei Iulia , Fadur Alina , Manolachie Adina , Zmau George , Anton Mihaela , Volovat Constantin , Ungureanu Maria Christina , Vulpoi Carmen

Introduction: Breast neuroendocrine carcinoma is a rare aggressive neuroendocrine tumour (NET) and the research on this subject is poor. Only seven studies were cited in the literature. Incidence in the population has not been reported, but the prevalence is under 0.1% of all breast carcinomas.Case report: AV, 72, is hospitalised for bone pain and significant weight loss (15 kg in 2 months). Patient’s previous history are: diabetes, hypertension, no...

ea0035p592 | Endocrine tumours and neoplasia | ECE2014

Pancreatic neuroendocrine tumour with a silent long evolution: case report

Manolachie Adina , Crumpei Felicia , Volovat Constantin , Bodescu Ioana , Idriceanu Jeanina , Vasiliu Ioana , Fadur Alina , Preda Cristina , Vulpoi Carmen

Pancreatic neuroendocrine tumors (pNET) represent 1.3% of pancreatic tumours, ~65% patients presenting with metastatic/unresectable disease. Clinically, pNET may be asymptomatic, accompanied by carcinoid syndrome or abdominal pain.Patient N.A. aged 73, with a history of hemorrhagic pancreatitis, was diagnosed in 2003 with a hyperechoic heterogeneous solid pancreatic tumour of 28/28 mm. No therapy/monitoring were proposed. After 7 years of asymptomatic ev...

ea0035p819 | Paediatric endocrinology | ECE2014

Pseudohypoparathyroidism: challenging diagnosis due to autism and epileptic seizures

Idriceanu Jeanina , Rusu Cristina , Bodescu Ioana , Vasiliu Ioana , Manolachie Adina , Fadur Alina Daniela , Preda Cristina , Mogos Voichita , Vulpoi Carmen

Pseudohypoparathyroidism (PHP) is an uncommon sporadic or inherited genetic disorder subdivided into several distinct entities characterized by parathyroid hormone (PTH) resistance in association with distinctive skeletal and developmental defects.We report a case of a 7 years and 8 months old boy, evaluated at the Endocrinology Department of ‘St Spiridon’ Hospital Iasi in January 2013, who had a history of hypothyroidism diagnosed at the age o...

ea0041ep371 | Clinical case reports - Thyroid/Others | ECE2016

A girl with Cornelia de Lange syndrome with good response on GH therapy: case report

Zmau George-Sebastian , Beleceanu Alina Daniela , Rusu Cristina , Braha Elena , Ungureanu Maria-Christina , Stefan Roxana , Manolachie Adina , Armasu Ioana , Constantinescu Georgiana , Vulpoi Carmen

Introduction: Cornelia de Lange Syndrome (CDLS) a relatively uncommon genetic disorder diagnosed mainly by clinical features: distinctive facial features, developmental delay, hirsutism, mental retardation and structural abnormalities. Most cases are due to spontaneous mutations (NIPBL on chromosome 5, SMC1A on X chromosome, and SMC3 on chromosome 10). Short stature in CDLS is due to GH deficiency and resistance.Case report: We present a 9-year-old girl,...