Searchable abstracts of presentations at key conferences in endocrinology

ea0081p478 | Thyroid | ECE2022

Thyroid nodules and glucose metabolism derangements: does sex matter?

Gagliardi Irene , Gobbo Alberto , ROSSI ROBERTA , Rossi Martina , Rosaria Ambrosio Maria , Chiara Zatelli Maria

Background: Glucose metabolism derangements (GMD) and thyroid nodules (TN) are the most frequent endocrine disorders. A relationship between these conditions has been suggested, but data are still controversial and no evidence was reported regarding sex differences.Aim: To evaluate the distribution of impaired fasting glucose (IFG), normal glucose tolerance (NGT), impaired glucose tolerance (IGT), type 2 diabetes (T2DM) and TN according to sex.<p cla...

ea0090p664 | Endocrine-related Cancer | ECE2023

Mutational profiles of typical and atypical bronchial carcinoids

Gagliardi Irene , Borges de Souza Patricia , Rossi Lucrezia , Rosaria Ambrosio Maria , Chiara Zatelli Maria

Introduction: Typical and Atypical bronchial carcinoids (TBC and ABC) are rare neuroendocrine neoplasms (NEN). TBC are low grade and well-differentiated NEN often with indolent clinical behavior, slow growth, rare extra-thoracic metastases, and with a long survival following surgical resection. Conversely, ABC have often a worse prognosis with a greater tendency to metastasize and recur. A better understanding of TBC and ABC genetic background would help in evaluating prognosi...

ea0070aep603 | Pituitary and Neuroendocrinology | ECE2020

TGF-β increases caspase 3 activation and migration in bronchial carcinoids

Borges de Souza Patricia , Tagliatti Valentina , Capobianco Simonaco , Rosaria Ambrosio Maria , Chiara Zatelli Maria

Introduction: Typical and atypical bronchial carcinoids (TBC and ABC) are well-differentiated neuroendocrine neoplasms (NEN). First-line treatment is radical removal of the primary tumour; however, management of metastatic BC is still challenging. Bronchial carcinoids (BC) may benefit from treatment with mTOR inhibitors, although response rates are moderate. TBC have shown reduced sensibility to mTOR inhibitors respect to ABC, notwithstanding its less aggressive behaviour. PI3...

ea0073pep15.3 | Presented ePosters 15: Late Breaking | ECE2021

TGF-β increase caspase activation and migration in typical bronchial carcinoids

Patricia Borges de Souza , Gagliardi Irene , Martelli Mariano , Ambrosio Maria Rosaria , Maria Chiara Zatelli

IntroductionTypical bronchial carcinoids (TBC) are rare well-differentiated neuroendocrine neoplasms (NEN) of the lung whose management can still be very challenging. In fact, the gold-standard treatment for TBC is total resection of the primary tumour; however, in case of metastatic disease adjuvant therapy with the mTOR inhibitor everolimus (eve) might be recommended. Unfortunately, prognosis may be very poor in cases showing moderate response rates to...

ea0077oc1.5 | Reproductive and Neuroendocrinology | SFEBES2021

Is radiotherapy for pituitary adenoma or craniopharyngioma associated with increased risk of second brain tumour? A long-term multi-centre study of 3,679 patients

Hamblin Ross , Vardon Ashley , Akpalu Josephine , Tampourlou Metaxia , Spiliotis Ioannis , Sbardella Emilia , Lynch Julie , Shankaran Vani , Mavilakandy Akash , Gagliardi Irene , Meade Sara , Hobbs Claire , Levy Miles J , Cameron Alison , Grossman Ashley , Rosaria Ambrosio Maria , Chiara Zatelli Maria , Reddy Narendra , Bradley Karin , Murray Robert D , Pal Aparna , Karavitaki Niki

Background: Current conclusions on risk of second brain tumour following radiotherapy for pituitary adenoma or craniopharyngioma are challenged methodologically by small patient sample size, selection biases or lack of appropriate controls.Objective: To ascertain whether radiotherapy for pituitary adenoma or craniopharyngioma is associated with increased second brain tumour risk, through use of appropriate methodology.Design: Multi...