Searchable abstracts of presentations at key conferences in endocrinology

ea0056p1028 | Thyroid (non-cancer) | ECE2018

IgM thyroglobulin autoantibodies are detectable in serum of patients with subacute thyroiditis

Brancatella Alessandro , Ricci Debora , Marino Michele , Vitti Paolo , Latrofa Francesco

Context: Subacute thyroiditis (SAT) is an inflammation of the thyroid, likely caused by a viral infection. IgG Autoantibodies (Ab) to the main thyroid antigens, including thyroglobulin (Tg) (TgAb) have been reported in a few patients with SAT and their appearance is usually transient. We investigated whether IgM TgAb can be detected in sera of patients with SAT.Design: Serum samples were collected from 17 patients with SAT, ten with Graves’ disease ...

ea0049ep1247 | Thyroid (non-cancer) | ECE2017

Action of several bioavailable antioxidants in orbital fibroblasts from patients with Graves’ Orbitopathy (GO): a new frontier in GO treatment?

Dottore Giovanna Rotondo , Casini Giamberto , Franceschini Stefano Sellari , Nardi Marco , Vitti Paolo , Marcocci Claudio , Marino Michele

Oxidative stress plays a crucial role in the pathogenesis of Graves’ Orbitopathy (GO), supporting the use of antioxidants in GO patients. Selenium has a beneficial effect, but other antioxidants have not been investigated. Here we evaluated several antioxidants in primary cultures of orbital fibroblasts from GO patients and control subjects. The following substances were tested: Vitamin C (Vit-C), N-Acetyl-l-Cysteine (NAC), melatonin (Mel), retinol (Ret), beta-carotene (b...

ea0084op-10-47 | Oral Session 10: Young Investigators / Clinical and Translational | ETA2022

Putative protective role of anti-nuclear antibodies in graves’ orbitopathy

Lanzolla Giulia , Comi Simone , Puccinelli Lisa , Menconi Francesca , Marcocci Claudio , Marino' Michele

Objectives: A sporadic association between thyroid and non-organ-specific autoimmunity has been reported, which could be relevant for Graves’ orbitopathy (GO), an autoimmune disease affecting orbital connective tissue. We investigated whether there is an association between GO and anti-nuclear antibodies (ANAs).Methods: We performed a cross-sectional investigation in 265 consecutive patients with Graves’ disease (GD) who came to our observation...

ea0084ps2-07-58 | Graves’ Disease 1 | ETA2022

High IGG4 serum levels in graves’ disease compared with nonautoimmune hyperthyroidism

Comi Simone , Lanzolla Giulia , Giudetti Matilde , Menconi Francesca , Marcocci Claudio , Marino Michele

Objectives: A role of IgG4 in Graves’ disease (GD) has been proposed, although the available data are conflicting. In addition, an association between Graves’ orbitopathy (GO) and IgG4-related disease has been postulated, but no firm demonstration has been obtained. Thus, the aim of the present study was to investigate the role of IgG4 in GD.Methods: We performed a cross-sectional investigation in 351 consecutive patients (F=284, M=67; age 48.2...

ea0084op-05-24 | Oral Session 5: Autoimmunity | ETA2022

Sirolimus for graves’ orbitopathy: A novel drug for the management of patients with moderate-to-severe graves’ orbitopathy?

Lanzolla Giulia , Novella Maglionico Maria , Comi Simone , Menconi Francesca , Posarelli Chiara , Figus Michele , Marcocci Claudio , Marino' Michele

Background: Sirolimus is an immunosuppressive drug with anti-fibrotic and anti-proliferative activities. In vitro, sirolimus inhibits differentiation of orbital fibroblasts from patients with Graves’ orbitopathy (GO), suggesting a possible use in clinical practice.Methods: We performed a retrospective investigation aimed at evaluating the effects of sirolimus as a second-line treatment for moderate-to-severe, active GO, compared with methyl...