Endocrine Abstracts

Introduction: Foetus is dependent on maternal thyroid hormone production during the first trimester. Thus, maternal thyroid dysfunction and thyroid antibodies may affect thyroid function of the offspring.Subjects and methods: We studied a subcohort (n=2000 mother–child-pairs) from a prospective population-based Northern Finland Birth Cohort 1986 (singleton births, total n=9247) covering data throughout pregnancy, childhood and adolesce...

Background: Statin medication is commonly used in prevention of cardiovascular diseases. Pooled evidence shows that statin therapy is associated with increased risk of incident diabetes, but studies vary in results and there is no consensus of the diabetogenic mechanism of statins. Beta blockers and diuretics are commonly used antihypertensive agents that also have been shown to increase the risk of incident diabetes. Our objective was to examine the effects of statins, beta b...

Background: Among patients diagnosed with primary aldosteronism (PA) due to an aldosterone producing adenoma (APA), about 10% fail to normalize aldosterone hypersecretion after unilateral adrenalectomy, and may instead have bilateral aldosterone producing hyperplasia. With routine histopathology it may be difficult to distinguish between APA and hyperplasia. We have recently reported the use of specific antibodies to identify the source of aldosterone excess in the removed adr...

Background: Primary aldosteronism (PA) accounts for 5–10% of all hypertension. In about 30% of PA patients the disease is unilateral caused by an adenoma or rarely unilateral hyperplasia. Cure rate from unilateral adrenalectomy, defined as normalized aldosterone secretion, is high but only 30–35% will obtain complete resolution of hypertension. We have studied pre- and postoperative characteristics potentially important for biochemical cure and normotension after adr...

Introduction: Thoracic Endometriosis Syndrome (TES) is characterized by clinical symptoms associated with menstruation (eg, catamenial pneumothorax (CP), chest pain, and others) not obligatorily requiring histological confirmation. The treatment is burdened with frequent recurrences. This study aimed to characterize the treatment of women with TES and assess the concomitant diseases.Methods: A developed online survey was published in patients’ suppo...

Thyroid diseases affect up to 4% of all pregnancies. Several evidence-based recommendations have been created to observe and treat thyroid diseases in pregnant women. We studied whether the diagnostics and treatment of hypothyroidism among pregnant women have improved in the course of time. Data consisted of all singleton pregnancies (N=571785) during 2004–2013 in Finland, collected from the Finnish Medical Birth Register (MBR). Data on maternal thyroid diseases ...

Background: The age at adiposity rebound (AR), at which BMI begins to rise after infancy around the age of 5 years, is associated with obesity and metabolic alteration in later life. Given that polycystic ovary syndrome (PCOS) has strong metabolic components, early growth patterns could reveal predisposition for PCOS. Thus, we aimed to investigate the associations of growth trajectories from birth to puberty with PCOS diagnosis,vbody composition and hyperandrogenism later in a...

Estrogen receptor α (ERα) is a key transcriptional regulator in the majority of breast cancers. ERα-positive patients are frequently treated with tamoxifen, but resistance is common. Through ChIP-seq analyses, we presviously identified direct target genes of ERα acting in complex with SRC1, SRC2 or SRC3 (Zwart et al., 2011 EMBO J). Only the 111 genes there were under direct control of ERα in conjunction with SRC3 (but not the other two p160s) predicted...

Background: Cardiovascular disease is an important cause of morbidity/mortality in chronic GH hypersecretion.Aim: To evaluate cardiovascular system in a large series of patients with pituitary gigantism. Standard case report forms were used with height assessments related to local country norms. Results: 151pts (123 male) with GH-excess and abnormal growth velocity for age or final height >2SD over local norms had complete data on cardiac assessments...