Searchable abstracts of presentations at key conferences in endocrinology

ea0037gp.02.07 | Adrenal (1) | ECE2015

Urinary free cortisone as a potential biomarker in diagnosing patients with mild Cushing's syndrome

Trementino Laura , Concettoni Carolina , Martino Marianna , Marcelli Giorgia , Michetti Grazia , Boscaro Marco , Arnaldi Giorgio

Introduction: Urinary free cortisol (UFC) determination has suboptimal sensitivity (SE) and specificity (SP) especially in mild Cushing’s syndrome (CS).Aim: To determine the performance of UFC and its metabolite cortisone (UFE) measured using accurate assays such as HPLC and LC–MS/MS in diagnosing patients with CS.Patients and methods: Sixty-seven patients with CS were compared to 49 sex- and age-matched non-CS. UFF and U...

ea0070aep1004 | Hot topics (including COVID-19) | ECE2020

Impact of covid-19 pandemic on psychophysical stress in patients with adrenal insufficiency: The corti-covid study

Martino Marianna , Aboud Nairus , Fabio Cola Marco , Giancola Giulia , Ciarloni Alessandro , Salvio Gianmaria , Arnaldi Giorgio

Background: COVID-19 pandemic is a novel, potentially adverse condition for patients with adrenal insufficiency (AI), whose life expectancy and quality of life (QoL) are impaired due to their risk of infections and stress-triggered acute events. Therapeutic usefulness of glucocorticoids in COVID-19 is debated, but infected AI patients require prompt replacement tailoring.Objectives: In a cohort of AI patients, to assess:– the...

ea0056p58 | Adrenal cortex (to include Cushing's) | ECE2018

The diagnostic accuracy of increased late night salivary cortisol for Cushing’s Syndrome: a real-life prospective study

Ceccato Filippo , Marcelli Giorgia , Martino Marianna , Concettoni Carolina , Brugia Marina , Trementino Laura , Michetti Grazia , Arnaldi Giorgio

Introduction and aim: A prompt diagnosis of Cushing’s Syndrome (CS) in high-risk populations is mandatory: 1-mg dexamethasone suppression test (1-mg DST); late night salivary cortisol (LNSC) and urinary free cortisol (UFC) are recommend, despite thresholds calculated in retrospective studies. Our aim was to study the diagnostic accuracy of LNSC measured with chemiluminescence assay in a prospective study, confirming discrepancies with mass spectrometry (MS).<p class="...

ea0056p62 | Adrenal cortex (to include Cushing's) | ECE2018

Different biological and functional features in patients with Cushing’s disease harboring micro- or macro-adenomas

Ceccato Filippo , Martino Marianna , Pinelli Silvia , Trementino Laura , Barbot Mattia , Boscaro Marco , Arnaldi Giorgio , Scaroni Carla

Background: ACTH-secreting pituitary adenomas represent two-thirds of Cushing’s syndrome (CS), the so-called Cushing’s disease (CD). These tumors are sometimes >10 mm in maximal diameter (macro-CD), but the majority of them are <10 mm (micro-CD). The aim of this study was to compare baseline characteristics of patients with micro-CD and macro-CD.Materials and methods: Clinical, hormonal and radiological data of 226 patients with CD were...

ea0081p22 | Adrenal and Cardiovascular Endocrinology | ECE2022

Mesenchymal Stem Cells exposed to persistently high glucocorticoid levels develop insulin-resistance and altered lipolysis: a promising in vitro model to study Cushing’s Syndrome

Di Vincenzo Mariangela , Martino Marianna , Lariccia Vincenzo , Giancola Giulia , Licini Caterina , Di Benedetto Giovanni Maria , Orciani Monia , Arnaldi Giorgio

Objective: In Cushing’s Syndrome, chronic glucocorticoid excess and their disrupted circadian rhythm lead to insulin-resistance, diabetes mellitus, dyslipidemia and cardiovascular comorbidities. As undifferentiated, self-renewing progenitors of adipocytes, mesenchymal stem cells may display the detrimental effects of glucocorticoid excess, thus revealing a promising model to study molecular mechanisms underlying metabolic complications of Cushing’s Syndrome.<p cl...

ea0081p412 | Pituitary and Neuroendocrinology | ECE2022

Sodium alterations impair the long-term prognosis of hospitalized patients with COVID-19 pneumonia: hospital readmissions and mortality rates after a 18-month follow-up

Martino Marianna , Aboud Nairus , Perrone Michele , Falcioni Paolo , Giancola Giulia , Ciarloni Alessandro , Salvio Gianmaria , Silvetti Francesca , Taccaliti Augusto , Arnaldi Giorgio

Background: Dysnatremia is common in hospitalized patients, often worsening the prognosis in pneumopathies and critical illnesses, such as COVID-19. Here, hyponatremia is an indicator of pulmonary involvement, while hypernatremia is associated with worse assistance outcomes, particularly when resulting from an overcorrected hyponatremia. Longer hospitalizations, readmissions after discharge and higher short- and long-term mortality rates have been observed in acute patients ex...

ea0073pep14.7 | Presented ePosters 14: COVID-19 | ECE2021

Psychological distress in patients with hypocortisolism during mass quarantine for Covid-19 epidemic in Italy

Simeoli Chiara , Barbot Mattia , Franco Marta , Martino Marianna , Morelli Valentina , Ferraù Francesco , Paragliola Rosa Maria , Hasenmajer Valeria , Guarnotta Valentina , Filpo Giuseppina De , Giordano Roberta , Dalmazi Guido Di , Sabbadin Chiara , Veresani Alessandro , Isidori Andrea M. , Mantovani Giovanna , Arnaldi Giorgio , Boschetti Mara , Scaroni Carla , Colao Annamaria , Iasevoli Felice , Pivonello Rosario

Beyond the huge impact on physical health, coronavirus disease-19 (COVID-19) epidemic represents a significant psychological stressor, causing effects on mental health. The psychological distress of the epidemic and consequent mass quarantine on patients with hypocortisolism, particularly frail and vulnerable to infections and stress, is unknown. The current multicentre, web-survey-based, case-control study evaluated the psychological impact of COVID-19 quarantine in a large c...