Searchable abstracts of presentations at key conferences in endocrinology

ea0034p363 | Steroids | SFEBES2014

Androgen receptor over expression drives lipid accumulation in human hepatocytes

Nikolaou Nikolaos , Nasiri Maryam , Gathercole Laura , Castro Silvia Parajes , Krone Nils , Valsamakis George , Mastorakos George , Tomlinson Jeremy

Non-alcoholic fatty liver disease NAFLD has been associated with androgen deficiency, yet in the majority of patients with non-alcoholic steatohepatitis NASH, androgens levels are normal. In contrast, women with polycystic ovarian syndrome PCOS, which is characterised by androgen excess, have evidence of increased liver fat. Our hypothesis is that androgen exposure to the liver may be crucial in the amount of lipid that can accumulate in hepatocytes. C3A human hepatoma cells w...

ea0035p820 | Paediatric endocrinology | ECE2014

Anti-oxidation improves in early puberty in normal weight and obese boys, in positive association with exercise stimulated GH secretion

Paltoglou George , Fatouros Ioannis , Valsamakis George , Shina Maria , Avloniti Alexandra , Chantzinikolaou Athanasios , Kambas Antonis , Draganidis Dimitris , Mantzou Aimilia , Papagianni Maria , Kanaka-Gantenbein Christina , Chrousos George , Mastorakos George

Oxidative stress in humans has been associated with obesity. Puberty is a maturation period characterized mainly by changes of the GH and the gonadotrophin hormones secretion. To investigate the possible association of the GH and the hypothalamic–pituitary–gonadal (HPG) axes before and during early puberty, with the pro- and anti-oxidation mechanisms 76 healthy, pre-pubertal normal weight (n=28), pre-pubertal obese (n=11), early pubertal normal weig...

ea0049s25.2 | HPA axis regulation during a woman's life: impact on metabolic outcomes | ECE2017

HPA axis, insulin resistance and adipocytokines in the fetal-maternal unit

Mastorakos George

‘Stress’ is defined as a state of disharmony or threatened homeostasis. Pregnancy is a transient period of relative hypercortisolism. Chronic or acute stressors influence maternal and fetal Hypothalamus-Pituitary-Adrenal Axes (HPA) during pregnancy. Insulin sensitivity is a feature of normal pregnancy, possibly reflecting an adaptive phenomenon aiming at diverting maternal glucose towards fetal needs. We investigated the effect of maternal stress into maternal insuli...

ea0016me3 | (1) | ECE2008

Contraception in the new millennium

Mastorakos George

The control of fertility constitutes a global health issue, because overpopulation and unintended pregnancy have both major personal and societal impact. Oral contraceptives (OCs) have been the gold standard for contraception since their introduction in 1960. They are used for both their contraceptive and noncontraceptive benefits. Hormonal contraceptives are made of either oestrogen-progestin combinations or progestins alone. Attempts have been made to use other classes of st...

ea0067gp35 | Poster Presentations | EYES2019

Energy deficiency, menstrual disorders and low bone mineral density in female athletes: a systematic review

Skarakis Nikitas S , Mastorakos George , Georgopoulos Neoklis , Goulis Dimitrios G

Background and aim: Low energy availability (LEA) may lead to menstrual disorders and low bone mineral density, predisposing to the female athlete triad (FAT) syndrome. The primary aim of this review was to systematically investigate the impact of sports on the energy status of professional female athletes compared to sedentary, recreationally active controls, with regard to their menstrual status and bone mineral density (BMD). A secondary aim was the estimation of the combin...

ea0056p912 | Female Reproduction | ECE2018

Presence of antiphospholipid antibodies is associated with increased failure rates of assisted reproductive techniques: a meta-analysis

Boutzios Georgios , Papadimitriou Eirini , Mathioudakis Alexandros , Vlachoyiannopoulos Panayiotis , Mastorakos George

Introduction: The presence of antiphospholipid antibodies is associated pathogenically with thrombotic vascular events and resulting pregnancy complications. Studies support that antiphospholipid antibodies (aPL) impair female fertility by interfering with endometrial decidualization and implantation. This meta-analysis aims to determine the prevalence of aPL in women undergoing assisted reproductive techniques (ART) for in Vitro Fertilization and Embryo Transfer (IVF-ET)....

ea0049ep1172 | Male Reproduction | ECE2017

Effects of anabolic androgenic steroids on the reproductive system of athletes

Christou Maria , Christou Panagiota , Markozannes Georgios , Tsatsoulis Agathocles , Mastorakos George , Tigas Stelios

Background: Anabolic androgenic steroids (AAS) are widely used to improve performance and/or enhance appearance. The aim of this study was to assess the impact of AAS on the reproductive system of athletes.Methods: An electronic literature search was conducted, using the databases MEDLINE, CENTRAL, Scopus and Google Scholar. Studies including AAS use in any type, dose, form or duration of intake were included in the review. Main outcomes were AAS effects...

ea0041ep661 | Female Reproduction | ECE2016

Follicular fluid Bisphenol A levels are higher and correlate negatively with the number of oocytes in women with tubal factor infertility compared to women with polycystic ovary syndrome

Boutzios Georgios , Mina Areti , Papoutsis Ioannis , Athanaselis Sotiris , Christopoulos Panagiotis , Mastrominas Minas , Kousta Eleni , Mastorakos George

Introduction: Bisphenol A (BPA) is a chemical compound found in a variety of everyday products. Exposure to BPA impacts negatively ovarian response, number of fertilized oocytes and implantation in women undergoing in vitro fertilization (IVF). The aim of the study was to determine BPA levels in women with polycystic ovary syndrome (PCOS) in comparison to women with tubal factor (TF) infertility who underwent IVF as well as to investigate their effect in critical endp...

ea0070ep73 | Bone and Calcium | ECE2020

Vitamin D revisited: Individualized Vitamin D normal values according to PTH levels; incidence and treatment of Normocalcemic Hyperparathyroidism in children

Papadimitriou Dimitrios T , Dermitzaki Eleni , Kleanthous Kleanthis , Papadimitriou Anastasios , Mastorakos George

Background: Childhood and adolescence are critical periods for the establishment of lifelong bone health. While most studies focus on vitamin-D regardless of PTH levels, Normocalcemic Primary Hyperparathyroidism (NPHPT) has been recognized more than 15 years ago as a variant of primary hyperparathyroidism (PHPT), characterized by persistently elevated PTH with normal albumin-adjusted total and ionized calcium, in the absence of secondary causes of hyperparathyroidism. PPHPT is...

ea0032p603 | Female reproduction | ECE2013

PON1-108 TT and PON1-192 RR genotypes are more frequently encountered in Greek PCOS than non-PCOS women, and are associated with hyperandrogenemia

Mastorakos George , Paltoglou George , Tavernarakis George , Christopoulos Panagiotis , Vlassi Margarita , Gazouli Maria , Deligeoroglou Efthimios , Creatsas George

Objective: To investigate the frequencies of three paraoxonase (PON)1 polymorphisms in Greek polycystic ovary syndrome (PCOS) and non-PCOS women, and their genotypes in association with hyperandrogenemia and insulin resistance.Design: Case–control genetic association study.Patients: PCOS cases (NIH criteria) and 112 controls.Main outcome measure: Genotyping of the c.−108C>T (PON1-108), the c.16...