Searchable abstracts of presentations at key conferences in endocrinology

ea0032p653 | Male reproduction | ECE2013

Metabolic syndrome correlates with prostate volume and biochemical and ultrasound signs of prostate inflammation in male members of infertile couples

Lotti Francesco , Corona Giovanni , Vignozzi Linda , Rossi Matteo , Maseroli Elisa , Gacci Mauro , Forti Gianni , Maggi Mario

Introduction: The impact of metabolic syndrome (MetS) on male infertility has been poorly studied. We recently reported that MetS is associated with hypogonadism, poor sperm morphology and testis ultrasound inhomogeneity. However, the possible associations between MetS and prostate-related symptoms and signs are still lacking.Methods: Out of 351 subjects without genetic abnormalities previously evaluated for couple infertility clinically and by scrotal u...

ea0026p138 | Male reproduction | ECE2011

Perceived ejaculate volume reduction in subjects with erectile dysfunction: psycho-biological correlates

Corona Giovanni , Boddi Valentina , Gacci Mauro , Sforza Alessandra , Forti Gianni , Mannucci Edoardo , Maggi Mario

Introduction: The disorders of orgasm/ejaculation include premature ejaculation, delayed ejaculation and perceived ejaculate volume reduction (PEVR). To explore the specific associations of PEVR in subjects with erectile dysfunction (ED).Methods: A consecutive series of 3141 subjects (mean age 51.6±13.1 years old) was studied. Among these, 71 have been excluded because they underwent prostate surgery. Different clinical and biochemical factors were ...

ea0063oc14.1 | Sex Hormones | ECE2019

Testosterone replacement therapy is able to reduce prostate inflammation in men with BPH, metabolic syndrome and hypogonadism: preliminary results from a randomized placebo-controlled clinical trial

Rastrelli Giulia , Cipriani Sarah , Lotti Francesco , Cellai Ilaria , Comeglio Paolo , Boddi Valentina , Della Camera Pierandrea , Gacci Mauro , Serni Sergio , Maggi Mario , Vignozzi Linda

Objectives: BPH is characterised by prostate inflammation, which frequently occurs in men with metabolic syndrome (MetS). MetS is often associated with low testosterone (T). Recent evidence shows that low, rather than high, T is associated with BPH/lower urinary tract symptoms (LUTS). To evaluate if T replacement therapy (TRT) for 6 months in BPH men with MetS and low T, is able to improve LUTS and prostate inflammation.Methods: 120 men in waiting list f...

ea0022p446 | Endocrine tumours &amp; neoplasia (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

The relationship of testosterone to PSA in men with sexual dysfunction

Corona Giovanni , Boddi Valentina , Lotti Francesco , Gacci Mauro , Carini Marco , De Vita Giulia , Sforza Alessandra , Forti Gianni , Mannucci Edoardo , Maggi Mario

Introduction: Concern about a testosterone-induced PSA increase is often perceived as one of the main limitations in treating hypogonadism even when it is symptomatic, such as in subjects with sexual dysfunction (SD). The aim of the present study is to evaluate the relationship between testosterone (T) and PSA levels in subjects with SD.Methods: We retrospectively evaluated the relationship between T and PSA in 2291 subjects seeking medical care at our O...

ea0016p672 | Steroid receptors | ECE2008

The vitamin D receptor agonist elocalcitol up-regulates L-type Ca2+ channel activity in human and rat bladder

Morelli Annamaria , Squecco Roberta , Francini Fabio , Failli Paola , Filippi Sandra , Chavalmane Aravinda , Fibbi Benedetta , Mancina Rosa , Vignozzi Linda , Silvestrini Enrico , Gacci Mauro , Colli Enrico , Adorini Luciano , Maggi Mario

Human bladder contraction mainly depends on Ca2+ influx, via L-type voltage-gated Ca2+ channels, and on RhoA/Rho-kinase contractile signalling, a pathway up-regulated in overactive bladder (OAB) syndrome. Elocalcitol (Elo) is a vitamin D receptor agonist inhibiting RhoA/Rho-kinase signalling in rat and human bladder, shown to ameliorate OAB symptoms in a clinical study. Since in normal bladder from Sprague–Dawley (SD) rats Elo treatment delayed the c...

ea0014p627 | (1) | ECE2007

Characterization and functional role of an androgen-dependent PDE5 activity in bladder

Filippi Sandra , Morelli Annamaria , Sandner Peter , Fibbi Benedetta , Mancina Rosa , Marini Mirca , Gacci Mauro , Vignozzi Linda , Barbara Vannelli Gabriella , Carini Marco , Forti Gianni , Maggi Mario

Benign prostate hyperplasia (BPH) is the most common disease in the aging male, often comorbid with erectile dysfunction (ED). PDE5 inhibitors (PDE5i, sildenafil, tadalafil and vardenafil) decrease lower urinary tract symptoms (LUTS) in patients with ED and BPH. We studied PDE5 expression and activity in the human bladder and PDE5i effects both in vitro (human and rat) and in vivo (rat). PDE5 is highly expressed in rat and human bladder and immunolocalized in vas...

ea0032p655 | Male reproduction | ECE2013

Fat boosts, while androgen receptor activation counteracts, BPH-associated prostate inflammation

Vignozzi Linda , Gacci Mauro , Cellai Ilaria , Santi Raffaella , Corona Giovanni , Morelli Annamaria , Rastrelli Giulia , Comeglio Paolo , Sebastianelli Arcangelo , Maneschi Elena , Nesi Gabriella , De Nunzio Cosimo , Tubaro Andrea , Mannucci Edoardo , Carini Marco , Maggi Mario

Background: Metabolic syndrome (MetS) and benign prostate hyperplasia (BPH) are often comorbid. Chronic inflammation, a determinant pathogenic factor for BPH, is a putative link between the two conditions.Methods: In a multi-center cohort of BPH patients (n=244) who underwent prostatectomy, we evaluated whether MetS is associated with prostatic inflammation in BPH specimens. In addition, we investigated the in vitro inflammatory effects...