Searchable abstracts of presentations at key conferences in endocrinology

ea0032p731 | Obesity | ECE2013

Brite adipocytes: a role for cannabinoid receptor type 1 in brown adipose cell recruitment

Mazza Roberta , Quarta Carmelo , Pasquali Renato , Pagotto Uberto

Recent data showed the existence of a specific adipocyte population composed of ‘brite’ cells in white adipose tissue (WAT), characterized by a peculiar gene expression pattern including PRDM16. Despite showing a low basal UCP1 expression, these cells display higher UCP1 expression when stimulated. In view of the involvement of the endocannabinoid system in energy homeostasis, the aim of our work is to establish whether the CB1 receptor could be a target for brown ph...

ea0041ep784 | Obesity | ECE2016

The circulating fingerprint revealed by targeted metabolomic as biomarker of metabolic impairment in female overweight/obesity

Mezzullo Marco , Fanelli Flaminia , Fazzini Alessia , Baccini Margherita , Casadio Elena , Ibarra-Gasparini Daniela , Mazza Roberta , Vicennati Valentina , Fontanesi Luca , Pasquali Renato , Pagotto Uberto

The comprehension of the network of metabolic processes may help the understanding of the molecular pathways driving obesity and related complications. However this is a hard task due to the large number of actors and their complex interplay. We aimed at exploring by targeted metabolomic the circulating metabolite profile in lean (NW, n=42; BMI: 18.5–24.9 kg/m2) and age-matched overweight/obese (OB, n=37, BMI≥25.0 kg/m2), drug...

ea0022h2.1 | Oral Communications Highlights 2 | ECE2010

ESE Young Investigator Award

Quarta Carmelo , Bellocchio Luigi , Mancini Giacomo , Mazza Roberta , Cota Daniela , Braulke Lutzie J , Fekete Csaba , Nisoli Enzo , Pasquali Renato , Lutz Beat , Marsicano Giovanni , Pagotto Uberto

The pharmacological blockade of cannabinoid receptor type 1 (CB1) has been shown to counteract diet induced obesity (DIO). An unsolved question is whether the effects of CB1 blockade on energy balance are due to peripheral or central mechanisms. This is an important clinical issue since the CB1 antagonist drugs have recently been withdrawn from the market due to their psychiatric side effects, and novel drugs selectively acting at peripheral le...