Endocrine Abstracts

Introduction: Papillary thyroid cancer (PTC) is usually tied to an excellent prognosis, with a 10-year disease specific survival rate of 98%. Nevertheless, some clinicopathological features are associated with a worse outcome. Therefore, a precise risk assessment is crucial for the clinicians deciding the most appropriate treatment for each tumour. Multifocal tumours (MFPTC) appear to have be a worse prognosis than unifocal tumours (UFPTC) in some series, but this aspect is di...

Introduction: American Thyroid Association (ATA) guidelines suggest considering hemithyroidectomy in patients with unifocal well-differentiated thyroid tumours,smaller than 4 cm, withoutpreoperative evidence of extrathyroidal extension (ETE) nor lymph node metastases. Although multifocal microcarcinomas are considered to increase the risk of structural disease recurrence from 1%–2% to 4%–6% compared to unifocal microcarcinomas, the ATA guidelines do not sugges...

Procalcitonin (PCT) is a sepsis diagnostic marker and mortality predictor, although its elevation can be related to other diseases such as medullary thyroid carcinoma (MTC). A 72-year-old woman was transferred to the intensive care unit of our institution from another center. One week before, she had been admitted with a clinical picture of progressive malaise, fever, and dyspnea. Weeks before her admission, she had consulted for dyspnea, anorexia, asthenia, and weight loss. I...

Rothmund-Thomson syndrome (RTS) usually presents with physical stigmata (poikiloderma, ectodermal dysplasia, juvenile cataracts…) and it´s associated with malignancies in patients with homozygous or compound heterozygous mutations in the RECQL4 helicase gene (RTS-II). Neoplasms include osteosarcoma in childhood and skin cancer later in life, with occasional malignancies affecting other tissues (leukemia, lymphoma and gastrointestinal adenocarcinomas). To ou...

Background and aimsG protein-coupled receptor 55 (GPR55) is a putative cannabinoid receptor, and l-α-lysophosphatidylinositol (LPI) is its only known endogenous ligand. Although GPR55 has been linked to energy homeostasis in different organs, its specific role in lipid metabolism in the liver and its contribution to the pathophysiology of non-alcoholic fatty liver disease (NAFLD) remains unknown.MethodWe...