Endocrine Abstracts

Introduction: It has been suggested that sexual dysfunction affects as many as 43% of women in the population. In relation to this, symptoms of hypoactive sexual desire disorder (HSDD) can be alleviated with testosterone replacement.Aim: To determine what is the pre- and 24-hour post dose circulating level of testosterone in women applying Testogel 16.2 mg/g.Methods: In a group of 10 menopausal women applying Testogel 16.2 mg/g at ...

Introduction: T2DM is one of the main causes of morbidity and mortality in the UK. Epigenetic mechanisms impact gene expression and could predispose individuals to a particular metabolic phenotype. We investigated association of LINE-1 methylation (a surrogate of global DNA methylation) with cardiometabolic parameters in a longitudinal cohort of T2DM patients.Methods: Global LINE-1 DNA methylation in blood-derived DNA samples from 795 (men 60%, women 40%...

Introduction: T2DM is one of the main causes of morbidity and mortality in the UK. Epigenetic mechanisms impact gene expression and could predispose individuals to a particular metabolic phenotype. We investigated association of LINE-1 methylation (a surrogate of global DNA methylation) with cardiometabolic parameters in a longitudinal cohort of T2DM patients.Methods: Global LINE-1 DNA methylation in blood-derived DNA samples from 795 (men 60%, women 40%...

Introduction: Previous studies have shown that PCOS (first described 1935) increases the future risk of hypertension and coronary artery disease.Aims: We investigated in women with PCOS, the link between social disadvantage and markers of cardiometabolic risk and how weight gain over time related to social disadvantage.Methods: In a primary care-based study, 1797 women were identified from patients attending one ...

Introduction: Polycystic ovarian syndrome (PCOS) is one of the commonest endocrine disorders affecting women of reproductive age. We examined the specific tests that are done in primary care to lead to the diagnosis of PCOS, and to support the diagnosis once made.Methods: 1797 women were identified from a pooled GP practice database. The search included all patients defined with PCOS or related terms. Records included demographic infor...

Introduction: Previous studies have shown that PCOS (first described 1935) increases the future risk of hypertension and coronary artery disease.Aims: We investigated in women with PCOS, the link between social disadvantage and markers of cardiometabolic risk and how weight gain over time related to social disadvantage.Methods: In a primary care-based study, 1797 women were identified from patients attending one ...

Introduction: Polycystic ovarian syndrome (PCOS) is one of the commonest endocrine disorders affecting women of reproductive age. We examined the specific tests that are done in primary care to lead to the diagnosis of PCOS, and to support the diagnosis once made.Methods: 1797 women were identified from a pooled GP practice database. The search included all patients defined with PCOS or related terms. Records included demographic infor...