Searchable abstracts of presentations at key conferences in endocrinology

ea0094p322 | Bone and Calcium | SFEBES2023

Osteoporosis in a young male patient

Tsoutsouki Jovanna , Behary Preeshila , Cox Jeremy , N Comninos Alexander

A 58 year-old man presented with backache and was found to have T10-T12 vertebral fractures on spinal-MRI. He was diagnosed with osteoporosis on a DEXA-scan (lumbar-spine T-score-2.6) and was treated with Alendronate and Cholecalciferol at a neighboring hospital. He was referred to the endocrine bone-clinic for a second opinion regarding his osteoporosis. He had a history of multiple small bone fractures and Brucellosis that required a 2-month bed-rest. His family history incl...

ea0091wf3 | Workshop F: Disorders of the parathyroid glands, calcium metabolism and bone | SFEEU2023

Differentiating Primary Hyperparathyroidism from Familial Hypocalciuric Hypercalcaemia Can Be Difficult: A Misleading Urinary Calcium to Creatinine Clearance Ratio

G Mills Edouard , J Hadjiminas Dimitri , Abbara Ali , Behary Preeshila , Cox Jeremy , N Comninos Alexander

Case: We report a 79-year-old female who was referred to our Endocrine Bone Unit with osteoporosis, which was initially treated with Alendronate (but poorly tolerated due to dyspepsia) followed by annual Zoledronate infusions. Her bone history was significant for a proximal humeral fragility fracture 30-years previously. She was an ex-smoker, had limited dietary calcium intake, and had a brother with osteoporosis. DEXA demonstrated T scores at lumbar spine -1.8, total hip -2.0...

ea0091cb58 | Additional Cases | SFEEU2023

Hypercalcaemia in a young female patient

Tsoutsouki Jovanna , North Matthew , Tebbs Daniel , Tharakan Goerge , Behary Preeshila , Cox Jeremy , N Comninos Alexander

A 35 year old lady presented with a one week history of back pain, myalgia, fatigue, epigastric pain, and persistent vomiting. She reported a four week history of reduced appetite and 4 kg weight loss. She had recently recovered from an uncomplicated COVID-19 infection. Past medical history included a previous eating disorder (anorexia and bulimia), and subsequent chronic gastritis. Drug history included Omeprazole 20 mg daily, Laxido 2 sachets daily and antacids (Rennies 4-8 ...

ea0086p167 | Adrenal and Cardiovascular | SFEBES2022

The Value of Baseline Cortisol in Predicting a Preserved Cortisol Response to Synacthen

Suh Sarah , Agha-Jaffar Rochan , Choa Dri , Bravis Vassiliki , Vakilgilani Tannaz , Yee Michael , N Comninos Alexander , Cox Jeremy , Robinson Stephen

Background: Adrenal Insufficiency (AI) presents a diagnostic and clinical challenge. While short Synacthen Tests (SSTs) are most commonly utilised to diagnose AI, the value of a baseline cortisol is being explored. We aimed to review indications for performing an SST and to determine the baseline cortisol that predicted a preserved cortisol response to Synacthen.Methods: Eight hundred and sixty SSTs performed in 621 individuals at a tertiary endocrinolog...

ea0086p37 | Bone and Calcium | SFEBES2022

The management of autosomal dominant hypoparathyroidism with CaSR mutation in pregnancy and breastfeeding

Halim Sandra , Rahim Haaris , Avari Parizad , Mulla Kaenat , Freudenthal Bernard , N Comninos Alexander , Agha-Jaffar Rochan , Robinson Stephen , Cox Jeremy

Autosomal dominant hypoparathyroidism (ADH) is caused by gain-of-function mutations in the calcium-sensing receptor (CaSR), increasing its sensitivity to extracellular calcium, suppressing PTH and resulting in hypocalcaemia. In contrast to idiopathic hypoparathyroidism, treatment to correct serum calcium results in high urine calcium excretion, causing nephrocalcinosis, stones and renal impairment. Unlike surgical hypoparathyroidism where calcium should be maintained, patients...

ea0065p373 | Reproductive Endocrinology and Biology | SFEBES2019

Should SHBG be measured in every patient before diagnosing hypogonadotrophic hypogonadism?

Phylactou Maria , Abbara Ali , Eng Pei Chia , Clarke Sophie A. , Papadopoulou Deborah , Izzi-Engbeaya Chioma , Jayasena Channa N , Comninos Alexander N , Tan Tricia , Dhillo Waljit S

Case: A 19-year-old British-Asian man presented with a two-year history of gynaecomastia. He had no other symptoms of hypogonadism. On examination, BMI was 28 kg/m2 and he had post-pubertal-sized testes (20 ml) with normal secondary sexual characteristics. Hypogonadism was confirmed by two morning fasting total testosterone levels of 4.7 and 5.2 (RR 9.2–31.6 nmol/l). Haemoglobin was normal (152 g/l) and serum oestradiol was <100 pmol/l. He had inappropriate...

ea0025p269 | Reproduction | SFEBES2011

Kisspeptin-54 injection stimulates activity of the human GnRH pulse generator in healthy women

Jayasena Channa N , Comninos Alexander N , Misra Shivani , Ali Abbara , Aniket Tavare , Donaldson Mandy , Ghatei Mohammad A , Bloom Stephen R , Dhillo Waljit S

Background: Kisspeptin is a novel hypothalamic hormone with powerful stimulatory effects on the hypothalamo-pituitary–gonadal (HPG) axis. Inactivating mutations in the kisspeptin receptor lead to pubertal failure. We have previously demonstrated that injection of kisspeptin-54 stimulates LH release in healthy men and women. Recent studies in animals suggest that endogenous kisspeptin may be involved in stimulating the GnRH pulse generator. Determining whether exogenous ad...

ea0094p116 | Reproductive Endocrinology | SFEBES2023

Patient and healthcare providers experience of access to menopause-related information and menopause-care provision across the UK: Results from a nationwide survey

Koysombat Kanyada , Pedder Hugo , Vinogradova Yana , Qayum Ambreen , N Comninos Alexander , Talaulikar Vikram , Panay Nick , S Dhillo Waljit , Mukherjee Annice , Abbara Ali

Menopause management guidelines advocate a personalised, evidence-based approach to menopause-care. This study explored the current landscape of menopause-care, from both patients’ and healthcare-providers’ perspectives, to better understand barriers to menopause-care across the UK.Methods: A 25-question online patient-survey and a 23-question GP-survey was designed with individuals with lived-experience of menopause to underst...

ea0094p267 | Reproductive Endocrinology | SFEBES2023

Kallmann syndrome with unilateral anosmia

Tsoutsouki Jovanna , N Comninos Alexander , Phylactou Maria , Chia Eng Pei , Patel Bijal , Modi Manish , Young Megan , Papadopoulou Deborah , R Howard Sasha , S Dhillo Waljit , Abbara Ali

Introduction: Kallmann syndrome (KS) is a rare genetic disorder typically due to defective migration of olfactory-axons and GnRH-neurons. KS results in congenital hypogonadotrophic hypogonadism (CHH) typically associated with absent (anosmia) or reduced (microsmia) sense of smell. Unilateral hypoplastic/absent olfactory bulbs on MRI are reported, although disturbance in smell is usually bilateral. Here, we present an unusual case of KS with unilateral anosmia....