Searchable abstracts of presentations at key conferences in endocrinology

ea0065p203 | Metabolism and Obesity | SFEBES2019

The track-pump study

Johnson Agnes , Oliver Nick , Godsland Ian , Hill Neil

Background: ‘Glycaemic tracking’ describes the stability of HbA1c over time commonly observed in individuals with type 1 diabetes (T1DM). Preliminary studies have noted the relationship between early metabolic control and long-term outcomes, while recent evidence has been presented for glycaemic tracking in a large number of newly diagnosed individuals with T1DM. The benefits of tight glycaemic control, in terms of reducing microvascular complications and lowering Hb...

ea0015p66 | Clinical practice/governance and case reports | SFEBES2008

Sepsis, metabolic acidosis and gestational diabetes: a missing clue

Baburaj Rajashree , Oliver Nick , Cox Jeremy , Teoh TG , Robinson Stephen

A 23-year-old Rwandan lady was 27 weeks pregnant and reported feeling non-specifically unwell for 3 days followed by 24 h of diarrhoea and vomiting. She denied fever, rash, polyuria, polydipsia, weight loss or foreign travel. She has sickle cell trait with no other past medical history. Laboratory glucose at 16 weeks gestation was 5.1 mmol/l.On admission she looked unwell and was tachycardic and dehydrated. Her capillary blood glucose was 17.9 mmol/l and...

ea0094p30 | Adrenal and Cardiovascular | SFEBES2023

Trials of therapy are subject to a placebo effect and should not be used

Bahowairath Fatima , Hag Sara , Oliver Nick , Meeran Karim

When patients with type 1 diabetes present with hyponatremia, Addison’s is an important condition to exclude. It is however important to consider other causes, and a trial of hydrocortisone is not part of the diagnostic test for adrenal failure. A 43-year-old lady, with a background of Type 1 Diabetes and depression, presented unwell with hyponatremia. Her basal cortisol was low 162 nmol/l along with an ACTH 16.2 ng/l. A short synacthen test (SST) revealed a baseline cort...

ea0077op6.3 | Endocrine Cancer and Late Effects | SFEBES2021

An unusual presentation of hypoglycaemia: An investigative challenge

Chia Eng Pei , Avari Parizad , Chen Runzi , Spalding Duncan , Oliver Nick , Wernig Florian

Prohormone convertase 1/3 (PC1/3), encoded by protein convertase subtilisin kexin type 1 (PCSK1), converts inactive prohormones such as pro-opiomelanocortin, proinsulin, proglucagon into biologically active peptides. Inherited genomic mutations of PCSK1 present with malabsorptive diarrhoea, hyperinsulinemic hypoglycaemia, central adrenal and thyroid defects and severe obesity. Somatic mutations of insulinomas are associated with genetic defects interfering with insulin secreti...

ea0028p111 | Clinical practice/governance and case reports | SFEBES2012

Asymptomatic hypercalcaemia in a hypoparathyroid patient: vitamin D toxicity or calcium alkali syndrome?

Misra Shivani , Ramachandran Radha , Zac-Varghese Sagen , Gulati Malvika , Meeran Karim , Oliver Nick

A 65-year-old lady presented to the emergency department with breathlessness due to an exacerbation of chronic airways disease. Her past medical history included laryngeal carcinoma treated with total-laryngectomy, thyroidectomy and adjuvant radiotherapy in 2003. She remained on stable post-operative replacement doses of 125mcg of levothyroxine and 1mcg 1-Alfacalcidol/1g Sandocal TDS for hypoparathyroidism for several years. Three days prior to her admission, strontium ranelat...

ea0025p69 | Clinical biochemistry | SFEBES2011

Hyponatraemia in a patient presenting with diabetic ketoacidosis: a case of polyglandular autoimmune syndrome type 2

Misra Shivani , Feeney Claire , Peters Debbie , Oliver Nick , Dornhorst Anne , Hatfield Emma

A 31-year-old male presented to A&E with confusion, lethargy, polyuria and blurred vision. The previous month he had been diagnosed with diabetes and started on metformin by his GP. On examination he was cachectic (BMI 17 kg/m2), dehydrated and hypotensive (88/56). Baseline investigations revealed a metabolic acidosis (pH 7.30), with capillary glucose 20 mmol/l and moderate ketonuria. Treatment for diabetic ketoacidosis was commenced. Further results revealed he...

ea0073oc1.6 | Oral Communications 1: Adrenal and Cardiovascular Endocrinology | ECE2021

All-cause mortality in adrenal insufficiency patients using prednisolone or hydrocortisone replacement

Ngaosuwan Kanchana , Johnston Desmond , Godsland Ian , Cox Jeremy , Oliver Azeem , Quint Jennifer , Oliver Nick , Robinson Stephen

BackgroundWhilst hydrocortisone is standard glucocorticoid replacement therapy in patients with adrenal insufficiency, some have considered prednisolone an alternative. Some data have shown diabetes and osteoporosis risk. Mortality of patients using prednisolone in relation with those using hydrocortisone is not known. We compared all-cause mortality risk compared to matched controls in patients with primary or secondary adrenal insufficiency using predn...

ea0073pep11.7 | Presented ePosters 11: Adrenal and Cardiovascular Endocrinology | ECE2021

All-cause mortality in adrenal insufficiency patients with primary and secondary adrenal insufficiency

Ngaosuwan Kanchana , Johnston Desmond , Godsland Ian , Cox Jeremy , Majeed Azeem , Quint Jennifer , Oliver Nick , Robinson Stephen

BackgroundIncreased mortality risk of patients with adrenal insufficiency has been inconsistently reported. This might have resulted from the disparity of time and place of clinical care between the study patients and reference population. Also, data of patients with secondary adrenal insufficiency was limited as majority focused on other types of pituitary disorders. Therefore, we compared all-cause mortality of patients with primary and secondary adren...