Searchable abstracts of presentations at key conferences in endocrinology

ea0037ep239 | Calcium and Vitamin D metabolism | ECE2015

Familial hypercalcaemic hypocalciuria in a woman with Graves' disease: a case report of mistaken identity

Novac Roxana

We present the case of a 58 years old woman with a long history of Graves’ disease and mild hypercalcaemia (total calcium registered a maximum of 11.1 mg/dl) that was first interpreted as a consequence of hyperthyroidia. After 10 year of being treated with anti-thyroid drugs the patient finally decides to undergo surgery. Immediately after surgery this particular patient does not develop hypoparathyroidism, her calcium level remaining a little high. Six weeks after surger...

ea0037ep1187 | Clinical Cases–Pituitary/Adrenal | ECE2015

Late diagnosis, early response - or the story of a smile

Novac Roxana , Rosu Nicoleta

We present the case of a 33-year-old male who addresses an endocrinology service for the first time in May 2014 for marked asthenia, drowsiness, muscular aches, and a delay in growing. The physiological exam showed difficulties in communicating and relation with the others based on his own negative image of himself, lack of self- trust, auto-isolation tendency, state of depression. We raised the suspicion of a panhypopitutarism confirmed by the lab exams that describe a somato...

ea0081ep185 | Calcium and Bone | ECE2022

Evaluation of response to alendronate treatment on osteoporosis using cathepsin K and other biomarkers

Novac Roxana , Costin-Ioan Popescu , Valentin-Adrian Cotirlet

Background: Osteoporosis has been an excruciating disease for many years now. Although various treatments are available, there is an unmet need for disease prognosis, early disease diagnosis and prediction of treatment efficacy. New biomarkers are crucial for the diagnosis or prognosis of a disease as well as for monitoring treatment efficacy and improve decision making. Cathepsin K is a cysteine protease that cleaves collagen type I, the major type of collagen found in bone, ...

ea0032p634 | Growth hormome IGF axis – basic | ECE2013

GH therapy: never say never; clinical case

Ghita Irina , Profiri Corina , Constantinescu Georgiana , Novac Roxana , Mogos Voichita

We present the case of a patient diagnosed with panhypopituitarism at an adult age. The tenth child of a poor family, PA consulted the endocrinologist accompanied by his 65 year old mother. PA was 20 years old at the first consultation. He was, however, entrapped in the body of a 12 year old child, being only 139 cm tall and having no signs of puberty onset. He was slightly eunuchoid, with long limbs, due to delayed puberty, with micropenis and lack of androgen dependent hair,...

ea0032p88 | Bone and Osteoporosis | ECE2013

Lean body mass and leptin, but not fat mass are independent predictors of bone mass in postmenopausal women

Constantinescu Georgiana , Novac Roxana , Gaspar Ioana , Preda Cristina , Vulpoi Carmen , Mogos Voichita , Branisteanu Dumitru D

Body weight is positively correlated to bone mass. While gravity represents a stimulation stress for bone turnover, endocrine function of adipocytes may also influence bone.Objectives: We investigated the relative influence of weight, body composition and leptin upon lumbar bone mass in pre and postmenopausal women.Materials and methods: Cross-sectional study including six groups varying from 8 to 15 pre- / postmenopausal healthy v...

ea0032p168 | Calcium and Vitamin D metabolism | ECE2013

A clinical case of complicated hyperparathyroidismwith diagnosis delay due to vitamin D deficiency

Novac Roxana , Constantinescu Georgiana , Oprea Andreea , Mogos Voichita , Branisteanu Dumitru D

We present the case of a 75-year-old woman with a 10-year history of nephrolithiasis, for which she endured several sessions of extracorporeal shockwave lithotripsy (ESWL). She was directed to the Endocrinology unit for further investigations, due to persistent albeit minor increased values of blood calcium (10.48 mg/dl, normal 8.4–10.2 mg/dl). Here, the clinical supposition of primary hyperparathyroidism was confirmed. The tests revealed a mild hypercalcemia with hypopho...

ea0026p521 | Bone/calcium/Vitamin D | ECE2011

Antagonism between body weight and adipocytokines on bone mass acquisition in pre- and postmenopausal women

Corina Buta , Dumitru Branisteanu , Cristina Preda , Didona Ungureanu , Ioana Gaspar , Roxana Novac , Voichita Mogos , Carmen Vulpoi

Introduction: Body weight is positively correlated to bone mineral density. The exact mechanism is unclear but gravity may be one of the involved factors. Adipocytokines (leptin and adiponectin), secreted by the adipose tissue, are involved in bone turnover. We investigated the influence of body weight, body composition, and adipocytokines upon bone mass in pre and postmenopausal women.Design: Cross-sectional study including six groups of 8 to 16 healthy...

ea0022p210 | Clinical case reports and clinical practice | ECE2010

Two rare genetic causes of aberrant growth: Robinow syndrome with partial GH deficiency and dwarfism and Simpson-Golabi-Behmel syndrome with gigantism

Branisteanu Dumitru , Repede Ionut , Novac Roxana , Turliuc Serban , Mogos Simona , Turliuc Dana , Mogos Voichita

We describe two very rare genetic diseases characterized by particular physical features and deviation from normal growth. The first patient, CM, was admitted for delayed growth (113 cm at 8 years of age, -3 S.D.). The child had short lower arms with small hands and clinodactyly of the fifth finger. He had round widely spaced eyes with long eyelashes, a flat profile and prominent forehead, short upturned nose, misaligned teeth and gum hypertrophy. We diagnosed a...

ea0022p231 | Clinical case reports and clinical practice | ECE2010

Isolated parietal-skull metastasis from a thyroid papillary carcinoma

Preda Cristina , Novac Roxana , Ciobanu Delia , Grigorovici Alexandru , Leustean Letitia , Ungureanu Maria-Christina , Cristea Cristina , Zbranca Eusebie

Papillary carcinoma is the most common differentiated malignant thyroid neoplasm. Metastasis commonly occur in regional lymph nodes and distant metastasis ia a late and rare occurrence.Papillary thyroid carcinoma with metastasis to the parietal skull is very rare.We present the case of a parital skull metastasis arising from a papillary carcinoma prior to the diagnosis of thyroid tumor. The patient was a 58 caucasian woman with pre...