Endocrine Abstracts

The purpose: to study prevalence of classical forms of 21-hydroxylasae deficiency according to the results of neonatal screening on a congenital adrenal hyperplasia (CAH) in Tyumen, Russia.The analysis of neonatal screening on CAH results in Tyumen for the period of 2003–2004. For the period under research 20011 newborn have been tested on the 17-OHP level. Measurement of 17-hydroxyprogesterone in blood samples was done in the central laboratory by ...

Background: Medullary and papillary thyroid carcinomas are distinct entities, regarding their incidence, cellular and genetic origin, histopathological features and prognosis, but there have been described a few cases of the two occurring simultaneously in the same patient. Medullary thyroid carcinoma represents between 1–5% of all thyroid malignancies and it is responsible for 12–13% of all cancer related deaths. The familial form (10–20% of the cases) is cause...

Background: Muscle weakness persists in patients with acromegaly (ACRO) even long-term after disease control. Mechanisms determining this sustained impairment are not known. We hypothesized that alteration of muscle architecture, due to intramuscular fatty infiltration, is associated with muscle dysfunction in these patients.Patients and Methods: Thirty-seven acromegalic patients [21 females and 16 males, mean (± s.d.)age, 53 ± 9 years...

Toxic adenomas (TA) and toxic multinodular goiters (TMNG) are frequent causes of hyperthyroidism in Galicia, an endemic goiter area. In some European countries, 40–80% of toxic goiters are caused by TSH receptor (TSHr) and Gs alfa-subunit (Gsa) mutations that activate cAMP pathway.Aims: To study 1) the prevalence of TSHr and Gsa mutations in TMNG and TA from Galicia, 2) the clonality of sequenced samples, 3) the constitutive activity of the identifi...

IntroductionUp by 30% of patients have recurrence in the first years after treatment of differentiated thyroid cancer (DTC) so it is necessary to have highly sensitive assays that allow adequate long-term follow-up. Nowadays, the measurement of serum thyroglobulin (Tg) is used as a tumor marker to monitoring DTC and must be determined along with levels of antithyroglobulin antibodies, since they can interfere in Tg immunoassays. Therefore, it is recommen...

Introduction: Sodium-glucose cotransporter 2 inhibitors (SGLT2i) therapyhas proven effective in type 2 diabetes but there is little data on its effect in patients with psychiatric comorbidity, who usually present worse metabolic and clinical control. The aim of this study was to evaluate if there are differences in the effect of this therapy in relation to the presence of these pathologies.Methods: 225 patients included in a therapy protocol with SGLT2i,...