Searchable abstracts of presentations at key conferences in endocrinology

ea0035p702 | Male reproduction | ECE2014

Effect of 17β-estradiol on germ cell apoptosis by modulating the expression of SCF/c-kit, FasL/FasR and regucalcin

Correia Sara , Alves Mario R , Martins Ana D , Cavaco Jose E , Oliveira Pedro F , Socorro Silvia

In the last years estrogens have emerged as important regulators in male reproductive function. Spermatogenesis depends on the tight control of germ cell apoptosis and several studies indicated estrogens as playing a role in this process. The stem cell factor (SCF), a membrane-bound cytokine, and its receptor (c-kit), and the Fas ligand (FasL)/Fas receptor (FasR) system are powerful mechanisms controlling germ cell proliferation and apoptosis through the direct membrane commun...

ea0073pep4.4 | Presented ePosters 4: Reproductive and Developmental Endocrinology | ECE2021

Insulin production by human spermatozoa in response to glucose stimuli

Carrageta David F. , Oliveira Pedro F. , Barros Alberto , Monteiro Mariana P. , Alves Marco G.

IntroductionMetabolic homeostasis in the testis is essential for a healthy spermatogenesis. Insulin is regarded as one of the most important intervenients in the metabolic regulation of spermatogenesis, where it acts directly on the differentiation of spermatogonia into primary spermatocytes or indirectly through the metabolic modulation of Sertoli cells. Additionally, insulin is hypothesized to play a major role on human spermatozoa capacitation, althou...

ea0081ep894 | Reproductive and Developmental Endocrinology | ECE2022

Mitochondrial uncoupling proteins (UCPs) are key regulators of human spermatozoa motility

Freire-Brito Lais , Carrageta David F. , Monteiro Bruno S. , Guerra-Carvalho Barbara , Barros Alberto , Oliveira Pedro F. , Alves Marco G.

Introduction: Mitochondrial uncoupling proteins (UCPs) are mitochondrial transmembrane channels belonging to the anion carrier family. Six UCP homologues (UCP1-6) had been identified with a ubiquitous distribution throughout the body and many different physiological functions. UCPs are important regulators of several biological processes, including thermogenesis, oxidative phosphorylation, ROS production, as well as cellular metabolism. However, the knowledge concerning the mo...

ea0081ep895 | Reproductive and Developmental Endocrinology | ECE2022

Sperm medium supplementation with hyperoside as a potential strategy to counteract spermatozoa dysfunction associated with oxidative stress

Moreira Mafalda V. , Pereira Sara C. , Pinto Soraia , Barros Alberto , Silva Branca M. , Alves Marco G. , Oliveira Pedro F.

Infertility is a global health problem that affects about 15% of couples and approximately half of infertility cases are associated with male factors. Oxidative Stress (OS) is reported as one of the major causes of male infertility, mainly due to spermatozoa’s vulnerability to the attack of reactive oxygen species (ROS). Infertile couples often recur to assisted reproductive technology (ART) to achieve a successful pregnancy. However, ART protocols also increase the expos...

ea0049ep1179 | Male Reproduction | ECE2017

Leptin modulates Sertoli cells mitochondrial function and biogenesis with implications for the nutritional support of spermatogenesis

Moreira Bruno M , D Martins Ana , Monteiro Mariana P , Sousa Mario , Alves Marco G , Oliveira Pedro F

Current lifestyle, characterized by physical inactivity and a poor diet, is heavily linked with an increased incidence of metabolic diseases. One of the most serious silent co-morbidities of those diseases is infertility. The hormonal link between food intake and energy homeostasis is mediated by the leptin ghrelin axis. Compelling evidence suggests that direct leptin’s action regulates cellular glucose homeostasis and mitochondrial biogenesis. We have recently shown that...

ea0081ep893 | Reproductive and Developmental Endocrinology | ECE2022

Mitochondrial uncoupling proteins (UCPs) regulate the mitochondrial activity of human sertoli cells

Carrageta David F. , Freire-Brito Lais , Monteiro Bruno S. , Guerra-Carvalho Barbara , Bernardino Raquel L. , Oliveira Pedro F. , Monteiro Mariana P. , Alves Marco G.

Introduction: Mitochondrial uncoupling proteins (UCPs) are channel proteins present in the mitochondrial inner membrane which are responsible for the transport of protons between the mitochondrial intermembrane space and the matrix. Currently, six UCP homologues had been identified (UCP1-6). UCPs are major regulators of reactive oxygen species (ROS) production, general cellular redox state and metabolism. UCPs also exhibit specific functions, such as UCP1 and thermogenesis or ...

ea0035p571 | Endocrine tumours and neoplasia | ECE2014

Androgens regulate gene expression of glucose transporters and glycolytic enzymes in prostate cancer cells

Vaz Catia V , Alves Marco G , Marques Ricardo , Moreira Paula I , Oliveira Pedro F , Cavaco Jose E , Maia Claudio J , Socorro Silvia

Prostate cancer (PCa) is an endocrine tumor that presents distinct metabolic features associated with neoplastic development, namely in the transition from the androgen-dependent to the androgen-independent phenotype that characterizes advanced stages of prostate cancer. Recently, we have found that LNCaP (androgen-responsive) and PC3 (androgen-nonresponsive) PCa cells present distinct glycolytic metabolism profiles in consequence of altered gene expression and/or activity of ...