Endocrine Abstracts

While low testosterone levels are associated with higher incidence of type 2 diabetes mellitus in males. In contrast, hyperandrogenism is associated with higher risk of type 2 diabetes mellitus in females.We, therefore, have assessed alterations in beta-cell functions before and after testosterone replacement therapy in male patients with idiopathic hypogonadotropic hypogonadism (IHH) and before and after anti-androgen therapy in patients with polycystic...

Objective: Familial hypercholesterolemia (FH) is a life-threatening genetic disease associated with elevated low density lipoprotein cholesterol (LDL-C) and premature coronary heart disease that is globally underdiagnosed and undertreated. This study aimed to search for the demographical characteristics, awareness and treatment adherence of underdiagnosed or undertreated FH patients from the records of the central biochemistry laboratory.Methods: Patient...

Objective: Metabolic disorders are common in patients with hypogonadism. Testosterone replacement therapy (TRT) significantly improves symptoms of testosterone deprivation such as mood, libido or musculoscelatal power. However, whether the metabolic and cardiovascular risk is improved is not clearly known. We aimed to search for the metabolic and cardiovascular effects of TRT.Design: Prospective study, performed in the outpatient units of Gulhane Medical...

Objective: Visfatin, a novel adipocytokine, is predominantly expressed in visceral fat and correlated with obesity. The pathophysiologic role of visfatin in metabolic syndrome (MS) is not clear. We aimed to investigate the relationship between plasma visfatin levels and components of MS, and also the effect of therapeutic lifestyle change (TLC) on these parameters.Design and methods: Nineteen patients (5 male, 14 female; mean age 51.0±9.3 years; bod...

Objective: The pleiotropic functions of statins are crucial in reducing cardiovascular events. There is controversy about their effects on insulin resistance. The aim of this study was to investigate the effect of Fluvastatin treatment on plasma adiponectin and insulin levels in a group of dyslipidemic population who had no confounding factors for insulin resistance such as diabetes or hypertension.Design and methods: Forty nine (27 male, 22 female; mean...