Searchable abstracts of presentations at key conferences in endocrinology

ea0081ep78 | Adrenal and Cardiovascular Endocrinology | ECE2022

Subthreshold cortisol deficiency-another ray in the spectrum?

Adamidou Foteini , Komzia Paraskevi , Kita Marina

Introduction: In Endocrinology, subclinical disorders meet certain diagnostic laboratory thresholds, but are by definition asymptomatic. Subthreshold disorders in Endocrinology have not been defined. We describe two cases of cortisol deficiency, primary and secondary, with normal baseline cortisol, which were by presentation clinical, but could be characterized as subthreshold by biochemical cut-off criteria.Case 1: A 47-year-old woman was referred for a...

ea0081ep207 | Calcium and Bone | ECE2022

rhPTH(1-84) treatment-induced increased bone turnover in a young woman with postsurgical hypoparathyroidism

Adamidou Foteini , Komzia Paraskevi , Mintziori Gesthimani , Kita Marina

Introduction: rhPTH(1-84) replacement is the treatment of choice in adults with hypoparathyroidism not adequately controlled on standard therapy. Although increased bone turnover markers have consistently been reported in trials of safety and efficacy, marked elevations coupled with significant symptoms have been rare. We describe a case of increased treatment-induced bone turnover, necessitating significant therapeutic adjustments and monitoring.Case re...

ea0081ep795 | Pituitary and Neuroendocrinology | ECE2022

Response to classic dynamic tests of a corticotropinoma due to Nelson’s syndrome

Adamidou Foteini , Komzia Paraskevi , Divaris Efstathios , Panagiotou Athanasios , Kita Marina

Introduction: Nelson’s syndrome is a rare complication of Cushing’s disease treated with bilateral adrenalectomy. There is no effective medical treatment yet. Nelson’s patients respond to hypothalamic stimuli distinctly from patients with Cushing’s disease and those with Addison’s disease. We describe the responses to standard ACTH stimulation tests in a patient with Nelson’s syndrome.Case report: A 42-year-old woman present...

ea0063p851 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

True silent pheochromocytoma: description of a rare entity

Adamidou Fotini , Komzia Paraskevi , Mpatsi Ourania , Georgiou Thomas , Kita Marina

Introduction: With the advent of modern imaging, up to 30% of adrenal pheochromocytomas are discovered incidentally in asymptomatic patients. Smaller tumors may be ‘pre-biochemical’ in their secretory capacity, but truly nonfunctioning tumors over 3 cm are exceedingly rare. We describe a case of a clinically and biochemically silent pheochromocytoma.Case report: A 65-year-old woman was found to have a left adrenal incidentaloma on an abdominal ...

ea0063p1163 | Thyroid 3 | ECE2019

Atypical hyperthyroidism in a case of neutrophilic dermatosis (Sweet’s syndrome)

Adamidou Fotini , Komzia Paraskevi , Georgiou Thomas , Kita Marina

Introduction: Sweet’s syndrome is a rare, acute febrile neutrophilic dermatosis, associated with a variety of inflammatory and neoplastic conditions, drug reactions and rarely with a spectrum of thyroid dysfunction. A possible link between thyroid autoimmunity and Sweet’s syndrome has been previously suggested by rare reports of Hashimoto’s thyroiditis, subacute thyroiditis and classic Graves’ disease. We describe a case of ‘atypical’ hyperthyroid...

ea0056p868 | Pituitary - Clinical | ECE2018

Hypothalamic-pituitary axis assessment in a clozapine treated patient with a pituitary adenoma

Adamidou Fotini , Komzia Paraskevi , Kalograni Fani , Anagnostis Panagiotis , Kita Marina

Background: Assessment of hypothalamic–pituitary adrenal axis in patients with schizophrenia is complex, as it involves both the disease process and antipsychotic medications. We present a case of a patient on long term clozapine with a concomitant pituitary adenoma who presented discordant responses to adrenal stimulation.Case: A 38-year old male was referred with chronic symptoms of reduced libido and associated low testosterone levels. He was tre...

ea0081p18 | Adrenal and Cardiovascular Endocrinology | ECE2022

Covid-19 infection: incidental diagnosis of pheochromocytoma in an adolescent bearing an uncommon mutation

Efstathiadou Zoi , Gogakos Apostolos , Komzia Paraskevi , Goulopoulou Sophia , Linos Dimitrios , Kita Marina

Introduction: Chest computed tomography imaging in patients with Covid-19 infection often reveals incidental adrenal lesions, which are subsequently investigated, after recession of the infection.Purpose: Description of a pheochromocytoma that was accidentally diagnosed in a teenager, during her hospitalization with Covid-19.Case description: A 17-year-old girl, who was diagnosed with covid-19 infection, by molecular testing 6 days...

ea0081p564 | Calcium and Bone | ECE2022

Quantification of cerebral calcification and nephrocalcinosis in patients with hypoparathyroidism

Adamidou Foteini , Chartampilas Evagelos , Komzia Paraskevi , Prassopoulos Panagiotis , Kita Marina , Papavramidis Theodosios S.

Introduction: Various methods to quantify calcified coronary plaque have been used in common clinical practice in the past few decades to compliment cardiovascular risk assessment. The estimation of calcium load in other organs and conditions has been at best semi-quantitative. Patients with long-standing hypoparathyroidism are known to suffer with nephrocalcinosis and basal ganglia calcification. We attempted to quantify end-organ calcium burden in a series of patients with v...

ea0081ep22 | Adrenal and Cardiovascular Endocrinology | ECE2022

Adrenal ganglioneuroma: presentation of two cases

Michou Athanasia , Efstathiadou Zoi , Komzia Paraskevi , Gogakos Apostolos , Divaris Efstathios , Kourkouta Georgia , Kita Marina

Introduction: Adrenal ganglioneuroma (AGN) is a rare (about 470 described cases), benign tumor arising from the neural crest tissue. These tumors are usually asymptomatic and incidentally detected. They have variable radiological features that often raise suspicion of malignancy. AGN are diagnosed at a mean age of 50 years, have no gender preference and are rarely associated with genetic syndromes.Aim: The presentation of two male patients, 24 and 53 yea...

ea0081ep676 | Pituitary and Neuroendocrinology | ECE2022

Idiopathic isolated adrenocorticotropic hormone deficiency

Komzia Paraskevi , Gogakos Apostolos , Kalograni Fanny , Tsoutsas Georgios , Kita Marina , Efstathiadou Zoi

Introduction: Idiopathic Isolated Adrenocorticotropic hormone (ACTH) deficiency (IIAD) is a rare cause of secondary adrenal insufficiency. It can present with a variety of clinical symptoms, mainly chronic fatigue and euvolemic hyponatraemia, and may coexist with autoimmune disease, most commonly Hashimoto’s thyroiditis. Radiographically, an empty sella turcica image can be seen. We present 3 cases of isolated ACTH deficiency.Case 1: A 47-year-old w...