Searchable abstracts of presentations at key conferences in endocrinology

ea0011p241 | Cytokines and growth factors | ECE2006

Effect of growth hormone deficiency in adults on insulin action and gene expression of selected adipokines in subcutaneous adipose tissue

Penesova A , Skopkova M , Pura M , Vlcek M , Radikova Z , Vorzakova I , Tajtakova M , Vanuga P , Belan V , Koska J , Payer J , Klimes I , Gasperikova D

Growth hormone deficiency (GHD) in adults seems to predispose to insulin resistance (IR). Development of GHD related IR could be associated with adipose tissue (AT) derived signals. To investigate the nature of this pathological regulation we 1) measured gene expressions for leptin, adiponectin, TNFalpha, IL-6, 11beta HSD1, SREBP, PPARgamma in the AT of untreated GHD adults, and 2) assessed effect of euglycemic hyperinsulinemia (HI) at the gene level.Met...

ea0029p472 | Clinical case reports - Thyroid/Others | ICEECE2012

Severe amiodaron: induced thyrotoxicosis

Dokupilova A. , Payer J.

Indroduction: Amiodaron is an potent antiarrhythmic drug used for the treatment of ventricular and supraventricular arrhythmias. Long-term amiodaron therapy can cause a thyroid abnormalities in up to 14–18% patients. There are two main forms of AIT: type 1, a form of iodine-induced hyperthyroidism, and type 2, a drug-induced destructive thyroiditis. Differentiation of these 2 types is essential for determining the best management of the disease.Case...

ea0029p428 | Clinical case reports - Thyroid/Others | ICEECE2012

Hungry bone syndrome in a patient with McCune–Albright syndrome after total thyroidectomy: case report

Kollerova J. , Koller T. , Kostalova L. , Payer J.

McCune–Albright syndrome (MAS) is a rare disease. It is characterized by a combination of polyostotic fibrous dysplasia, autonomous overproduction of hormones and skin hyperpigmentation.Thirty-year-old patient with significant bone deformities and the history of multiple fractures of long bones despite treatment presented with multinodular goiter with long standing hyperthyroidism. During thyroidectomy in 2009 two enlarged nodules suspected for bein...

ea0029oc10.5 | Pituitary Clinical 2 | ICEECE2012

Once-weekly, CTP-modified hGH (MOD-4023) is effective in growth hormone deficient adults: a phase II, dose and frequency finding study

Popovic V. , Goth M. , Vanuga P. , Payer J. , Pfeifer M. , Bidlingmaier M. , Fima E.

Objective: GH replacement therapy currently requires daily injections, which may cause poor compliance and distress for patients. CTP-modified hGH (MOD-4023) is being developed for once-weekly administration in GH Deficient adults and children. The present study evaluated the safety, pharmacokinetics (PK) and pharmacodynamics (PD) of MOD-4023 in GHD adults.Design and methods: 39 normalized GHDA patients currently treated with daily GH were randomized and...

ea0026p573 | Cardiovascular endocrinology and lipid metabolism | ECE2011

Low sex hormone binding globulin – strong association with metabolic syndrome in patients with acute coronary syndrome

Payer J P , Banarova A B , Koller T K , Jackuliak P J

Objective: Despite of conflicting data, reduced levels of endogenous sex hormones and especially sex hormone binding globulin (SHBG) seem to be associated with metabolic syndrome (MS). In this study we determined relationship between endogenous sex hormone levels and SHBG and components of metabolic syndrome in both sexes.Methods: In 39 men (median age 70.2) with total testosterone level in the lowest quartile of normal range (median 12.8 nmol/l) and 29 ...

ea0020p266 | Bone/Calcium | ECE2009

Vitamin D levels in young healtly premenopausal females in Slovakia

Vanuga P , Killinger Z , Masaryk P , Tomkova S , Kmecova Z , Spustova V , Stecova A , Payer J

Background: There is increasing body of evidence suggesting for low vitamin D levels in humans. The levels of vitamin D in nonselect populations of Europe, Middle East, Asia and Latin America had been repeatedly shown to be as low as 20-30 μg/l.Aim: The aim of our study was to examine serum 25-hydroxyvitamin D [25-(OH)D] levels in young healthy premenopausal women in Slovak population.Subjects and methods: The participants (<i...

ea0029p1196 | Obesity | ICEECE2012

Prediabetes in adult GH deficiency is associated with a substantial reduction in serum and adipose tissue expression levels of zinc-α2-glycoprotein

Balaz M. , Ukropcova B. , Kurdiova T. , Penesova A. , Skyba P. , Vlcek M. , Belan V. , Klimes I. , Payer J. , Imrich R. , Smith S. , Tkacova R. , Gasperikova D. , Ukropec J.

Adult GH deficiency (GHD) is associated with prediabetes and low levels of GH are found in obesity. We hypothesized that zinc-α2-glycoprotein (ZAG), a novel adipokine reduced in obesity, is regulated by GH. ZAG serum and adipose tissue expression were measured in three study populations: i) cachectic (BMI=19.3±0.5 kg/m2), lean/overweight (BMI=26.0±0.5 kg/m2) and obese (BMI=36.0±1.6 kg/m2) patients with chronic obstructive pu...