Endocrine Abstracts

Extracellular vesicles (EVs) constitute a novel biological entity to identify biomarkers, and as active players in the development of liver diseases. Omics technologies have been widely applied to characterize the content and function of EVs secreted by liver cells in different pathological scenarios including drug-induced liver injury (DILI), NAFLD and metabolic syndrome. Thus, transcriptomics and proteomics of these EVs have provided several low invasive candidate biomarkers...

In the last decade, cell-secreted extracellular vesicles (EVs) have been isolated from most of the fluids of the body. There are many different types of EVs that include different subpopulations of exosomes, microvesicles and apoptotic bodies, all of them varying in size, composition and intracellular origin. Many laboratories around the world have shown that its composition of lipids, proteins, messenger and micro RNAs is cell-type specific, and subject to changes in patholog...

Obesity is reaching epidemic levels especially in western countries and has become a major public health issue because is frequently associated with other comorbidities such as hypertension, dyslipidemia and diabetes. Therefore, there is increasing interest in the development of therapies against obesity that can offer additional improvements in those associated comorbidities. Unfortunately the current pharmacological treatments have demonstrated limited efficacy, leaving bari...

Data from the literature suggest that endogenous Cushing’s syndrome (CS) is an unusual disorder in the general population with a reported incidence of 2–3 cases per 1 million inhabitants per year. Patients who are not cured from CS have a poor prognosis with an increased mortality due to cardiovascular disease and significant morbidity that impairs quality of life. Recently published screening studies performed in obese patients with type 2 diabetes or patients with ...

Introduction: Cyproterone acetate is a progestogen that has an androgen receptor antagonist activity.There is contradictory data regarding its effects on the growth of meningiomas; it has been suggested that progestins promote growth as progesterone receptors predominate in meningioma tissue, but in vitro, it inhibited the growth of meningioma cells. We present a case where a brain meningioma may have grown following anti-androgen therapy for hype...

Introduction: Papillary microcarcinomas tirodieos (MCT) are tumours less than or equal to centimeter size, mostly indectectables in the clinic and found incidentally after a thyroidectomy performed for another reason, management is under discussion and its prevalence is increased ~30%, it is believed that the increased use of thyroid ultrasound.Review: 16 patients with MCT in a province of southern Spain and evaluate the clinical and prognostic variables...

Introduction: Pre- and postnatal factors have an influence on obesity the first year of life. Among them maternal glucose levels, breastfeeding, ablactation and recently sleep duration are under study in diverse populations.Methods: In a prospective study, we recruited 139 pregnant women and obtained fasting and post-load (75 g) glucose levels. We studied children robustness (waist girth/height) at 6 months and one year of age, and the influence of alter...

Introduction: Hypoglucemia is one of the most common endocrine symptoms and supposes a challenging in endocrine clinical practise. In most cases, are produced in relation with diabetes (drugs and diet). In other cases, there was an endogenous insulin production which cause the symptoms.Clinical report: A 58-year-old was attended in the Emergency Department with episodes of lightheadedness, diaphoresis, palpitation, tremulousness for month duration. In th...

Context: Vitamin D is a fat-soluble vitamin which requires the hydroxylation into 1,25-dihydroxyvitamin D (1,25-(OH)2D3) to be fully active. Vitamin D deficiency is a worldwide health problem associated to a wide range of acute and chronic diseases. On other hand, vitamin D supplementation has been proposed to reduced the risk of metabolic dysfunctions including obesity, type 2 diabetes and cardiovascular disease. Vitamin D interacts with the epigenetic m...

Background: Testosterone therapy (TTh) may produce various side effects, particularly erythrocytosis, with short-acting testosterone (T) injections presenting the greatest risk. Other causes are smoking and obesity. Erythrocytosis increases blood viscosity, which may lead to thromboembolic complications. Aim: to study the frequency of erythrocytosis induced by TTh and its predictive factors on transgender males (TM) in the Gender Unit of our hospital.Met...