Searchable abstracts of presentations at key conferences in endocrinology

ea0015p46 | Clinical practice/governance and case reports | SFEBES2008

Use of glitazones in type 2 diabetes

Rajeev Surya Panicker , Nair Satheesh Balakrishnan , Mahmoud Mohammed , Baglioni Piero

Aim: To compare the use of glitazones against NICE guidelines. (Glitazone recommended as second line therapy in combination with metformin or sulfonyl urea in patients with intolerance or contra-indications to any of the two, not as monotherpay or triple therapy or in combination with insulin).Methods: Patients on glitazone therapy (n=60) were randomly identified from a pharmacy data base from August to December 2006. Retrospective case note revie...

ea0016p164 | Comparative endocrinology | ECE2008

c-AMP production in in vitro VIP- and PACAP-induced adrenal secretion of the lizard Podarcis sicula

Valiante Salvatore , Prisco Marina , Sciarrillo Rosaria , Andreuccetti Piero , Laforgia Vincenza , De falco Maria

The action of the regulatory neuropeptides vasoactive intestinal polypeptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP) carries out through the shared receptors VPAC1 and VPAC2 and the exclusive PACAP receptor PAC1, all of which are G protein-coupled receptors. Formerly, we showed that the administration of both peptides enhance catecholamine, corticosterone and aldosterone release from adrenal cell co-culture. Further...

ea0014p528 | (1) | ECE2007

Adulthood follow-up of a large number of patients with congenital morphological alteration of anterior and/or posterior pituitary lobes

Ribichini Danilo , Ragazzini Cecilia , Zucchini Stefano , Pirazzoli Piero , Cicognani Alessandro , Vicennati Valentina , Pagotto Uberto , Pasquali Renato

Congenital morphological alteration of anterior and/or posterior pituitary lobes is a rare disease often associated with isolated or multiple hormonal deficiency. In this study we re-evaluated 24 adult patients, 20 males and 4 females, (23–46 years), in whom Nuclear Magnetic Resonance (NMR) showed congenital morphological alteration of the gland. Twenty out of 24 patients presented with an association of hypoplasic adenohypophysis and ectopic neurohypophysis, while 4 pres...

ea0013p29 | Clinical practice/governance and case reports | SFEBES2007

Hyperkalemia in a district general hospital

Rajeev Surya P , Nair Satheesh B , Mahmood Muhammed Muzaffar , Geen John , Baglioni Piero

Objectives: To assess the aetiology and management of hyperkalemia amongst inpatients in a district general hospital.Methods: Individuals with hyperkalemia (defined as potassium>6.5 mmol/L) were identified from a biochemistry lab database. Review of case records in a six month period to assess the aetiology and management. Patients on renal replacement therapy and those<18 years were excluded.Results: 45 patients were ident...

ea0099ep206 | Thyroid | ECE2024

Taking nothing for granted- Levothyroxine formulation

Samperi Irene , Bima Chiara , Radaelli Piero , Steffanini Mara , Chantal Ponziani Maria

Background: levothyroxine is the most common medication for the treatment of hypothyroidism. Usually, it is capable of restoring euthyroidism in most conditions. Absorption can be challenging, therefore different formulations are available (tablet, soft gel, liquid). Rarely it is necessary to use liothyronine to achieve normal TSH values.Clinical case: a 23 y/o woman was admitted to our outpatient clinic for severe hypothyroidism. She was diagnosed with ...

ea0023p31 | (1) | BSPED2009

Prophylactic Thyroidectomy in Children with Multiple Endocrine Neoplasia Type 2

Morkane Clare , Raptis Dimitri , Brain Caroline , Spoudeas Helen , Dattani Mehul , Hindmarsch Peter , Piero Agostino , DeCoppi Paolo , Kurzawinski Tom

Background: The most common cause of death in patients with Multiple Endocrine Neoplasia type 2 is medullary thyroid carcinoma. All patients with MEN2 develop this cancer and Prophylactic Thyroidectomy (PT) is recommended to prevent malignant transformation.Method: This study reviews our experience of treating children identified as carriers of a RET mutation diagnostic of MEN-2A. Data was collected by reviewing patient notes and hospital electronic data...

ea0016p642 | Reproduction | ECE2008

PACAP and PACAP receptors in the testis of cartilaginous fish Torpedo marmorata

Prisco Marina , Valiante Salvatore , Apicella Elisa , Agnese Marisa , Giudice Giuseppina Del , Angelini Francesco , Laforgia Vincenza , Andreuccetti Piero

The pituitary adenylate cyclase-activating polypeptide (PACAP), isolated for the first time from hypothalamic extracts (Miyata et al. 1989), was localized in some peripheral tissues such as adrenal, gastrointestinal tract, ovary and testis (Arimura et al. 1991, Watanabe et al. 1992, Gathei et al. 1993, Shioda et al. 1994, Kononen et al. 1994). It was previously demonstrated that in the testis PACAP was involved in the steroidogenesis r...

ea0016p766 | Thyroid | ECE2008

Higher prevalence of nodular goiter and thyroid carcinoma in patients with familial adenomatous poliposis (FAP)

Zirilli Lucia , Romano Stefania , Madeo Bruno , Carani Cesare , Benatti Piero , De Leon Maurizio Ponz , Roncucci Luca , Rochira Vincenzo

FAP is a dominant autosomic syndrome, due to mutation of the APC oncosuppressor gene, characterised by adenomatous polyps at the colon–rectal level, that progres to malignant degeneration. FAP extraintestinal manifestations include, although rare, the thyroid nodules and tumours. Neck ultrasound (US) is routinely useful to identify thyroid nodules, but the characterisation of their nature requires the cytology by a FNAb. The exact incidence of the thyroid tumours on FAP s...

ea0014oc5.4 | Thyroid basic | ECE2007

BRAFV600E mutations but not RET/PTC rearrangements are correlated with a lower expression of NIS mRNA expression in papillary thyroid cancer (PTC)

Romei Cristina , Piampiani Pamela , Faviana Pinuccia , Basolo Fulvio , Bottici Valeria , Sculli Mariangela , Berti Piero , Materazzi Gabriele , Pinchera Aldo , Elisei Rossella

Several studies have identified a relationship between oncogene activation and dedifferentiation of PTC. Mutations of RAS, RET/PTC and BRAF modulate the expression of thyroid genes. An impaired NIS expression has been demonstrated in PTCs harboring the BRAFV600E mutation.Aim of this study was to analyze BRAF and RET/PTC1-3 alterations and their influence on the expression of thyroid differentiation genes. Seventy-one PTC samples were studied. Quantitative analysis o...

ea0014p345 | (1) | ECE2007

Characterization of facilitative glucose transporters (GLUT) in human thyroid carcinoma cell lines

Ciampi Raffaele , Vivaldi Agnese , Piampiani Pamela , Agate Laura , Salvadori Piero , Del Guerra Alberto , Pinchera Aldo , Elisei Rossella

18FDG-PET is based on the capability of tumor cells to take up glucose. An increment in expression of the glucose transporter 1 (GLUT1) has been observed in thyroid tumors with poor prognosis but very few data are available about the expression of other glucose transporters in thyroid. Here, we study the expression and function of GLUT isoforms 1, 2, 3, 4, 6, 8, 10, 12 in human thyroid carcinoma cell lines ARO and FRO (anaplastic carcinoma), NPA (poorly-differentiated papillar...