Searchable abstracts of presentations at key conferences in endocrinology

ea0084ps1-03-25 | Thyroid Cancer CLINICAL 1 | ETA2022

Low-intermediate risk thyroid cancer: no benefit of postsurgical iodine?

Tumino Dario , Malandrino Pasqualino , Russo Marco , Piticchio Tommaso , Le Moli Rosario , Frasca Francesco

Objectives: Evaluate the benefit of postsurgical radioactive iodine (RAI) in patients with differentiated thyroid cancer (DTC) at low to intermediate risk of recurrent disease in whom not routinary use of RAI is recommendedMethods: We retrospectively evaluated 1316 patients with DTC diagnosed between 2009-2015. ATA low (LR) and intermediate (IR) risk were included in the study (PTC: tumor size > 1 cm, microscopic extrathyroidal invasion, <5 micro...

ea0084ps3-12-113 | Graves’ Disease 2 and Orbitopathy | ETA2022

Temporal trends in the clinical presentation of graves’ ophthalmopathy: a single – centre retrospective study

Le Moli Rosario , Naselli Adriano , Tumino Dario , Piticchio Tommaso , Vella Veonica , Belfiore Antonino , Frasca Francesco

Background: Graves’ ophthalmopathy (GO) is an autoimmune disease that affects particularly the retrobulbar soft tissues and represents the most common extrathyroidal manifestation of Graves’ disease (GD). Some studies suggest that GO in newly diagnosed patients in recent years has a trend towards a less severe clinical presentation, moreover we have no studies that focus the trend of clinical presentation of GO in the last decade on the population of our area.<p ...

ea0092op-06-04 | Oral Session 6: Pregnancy | ETA2023

Changes in TSH suppression during pregnancy reveals novel mechanism for increased thyroid hormone production: comparison between euthyroid and thyroidectomized pregnant women

Scuto Andrea , Tumino Dario , Gambero Federica , Di Benedetto Guenda , Piticchio Tommaso , Malandrino Pasqualino , Frasca Francesco

Objective: Clarify mechanisms determining thyroid homeostasis during pregnancy at hypothalamic-pituitary level.Methods: Retrospective analysis of 251 pregnant women. 220/251 euthyroid without thyroxine therapy (Group 1), 31/251 thyroidectomized under thyroxine replacement therapy (Group 2). Patients under thyroxine replacement therapy with a TSH between 0.4 and 4.0 were included in the study. Patients with combined T3/T4 therapy were excluded.<p clas...

ea0092op-11-01 | Oral Session 11: Autoimmunity / Hyperthyroidism | ETA2023

Effect of gluten-free diet on autoimmune thyroiditis progression in patients with no histological confirm of celiac disease: a meta-analisys

Piticchio Tommaso , Frasca Francesco , Malandrino Pasqualino , Trimboli Pierpaolo , Carrubba Nunzia , Tumminia Andrea , Vinciguerra Federica , Frittitta Lucia

Background: Hashimoto’s thyroiditis (HT) is the most common autoimmune disease worldwide. Prevalence of celiac disease (CD) is higher in HT patients and HT is the most prevalent coexisting disease in CD patients. In the last years, interest about gluten free diet (GFD) has increased for its supposed extraintestinal anti-inflammatory effect, so many patients with HT initiate GFD on their own.Objectives: Aim of this meta-analysis is to examine all qua...

ea0092ps1-02-02 | Graves’ Disease | ETA2023

Predetermined vs calculated 131I activity for the treatment of patients with graves’ disease: which is the best?

Arcidiacono Francesco , Barca Ignazio , Prinzi Antonio , Scuto Andrea , Volpe Salvatore , Piticchio Tommaso , Malandrino Pasqualino , Frasca Francesco , Belfiore Antonino

Background: Graves’ disease (GD) is an autoimmune disorder of thyroid gland and is the first cause of hyperthyroidism. Radioactive iodine (RAI) therapy is the most used second- line treatment after failure of anti-thyroid drugs. The optimal RAI’s activity to be administered may be predetermined or calculated. Whether the latter is better is still a matter of debate.Aim: To compare the risk of persistent hyperthyroidism in GD patients treated wi...

ea0092ps3-29-03 | Treatment 2 | ETA2023

TKIS for advanced thyroid cancer increase tsh levels in thyroidectomized patients: A meta-analysis

Piticchio Tommaso , Belfiore Antonino , Malandrino Pasqualino , Trimboli Pierpaolo , Gambero Federica , Scuto Andrea , Volpe Salvatore , Di Benedetto Guenda , Dario Tumino , Le Moli Rosario , Privitera Grete , Pulvirenti Alfredo , Frasca Francesco

Background: Tyrosine kinase inhibitors (TKIs) are modern antineoplastic molecules widely used in the medical treatment of many cancers including iodine refractory differentiated thyroid carcer (DTC) and advanced medullary thyroid cancer (MTC). In patients with thyroid gland, TKIs frequently cause a destructive and/or autoimmune thyroiditis with consequent hypothyroidism. However, authors have reported unexpected TSH increase or hypothyroidism even in patients with total thyroi...