Searchable abstracts of presentations at key conferences in endocrinology

ea0011s98 | Metabolic syndrome | ECE2006

Ghrelin update

Popovic V

Ghrelin is the brain-gut peptide with growth hormone (GH)- releasing and appetite-inducing activities. Reviewed experimental evidence confirms the role of endogenous ghrelin in regulating GH secretion while studies in humans still fail to pinpoint the exact role of ghrelin in GH secretion. Accumulating evidence supports that ghrelin/GH secretagogue receptor (GHS-R) axis contributes to the maintenance of body weight. Evidence suggest the role of environmental factors modulating...

ea0029oc10.5 | Pituitary Clinical 2 | ICEECE2012

Once-weekly, CTP-modified hGH (MOD-4023) is effective in growth hormone deficient adults: a phase II, dose and frequency finding study

Popovic V. , Goth M. , Vanuga P. , Payer J. , Pfeifer M. , Bidlingmaier M. , Fima E.

Objective: GH replacement therapy currently requires daily injections, which may cause poor compliance and distress for patients. CTP-modified hGH (MOD-4023) is being developed for once-weekly administration in GH Deficient adults and children. The present study evaluated the safety, pharmacokinetics (PK) and pharmacodynamics (PD) of MOD-4023 in GHD adults.Design and methods: 39 normalized GHDA patients currently treated with daily GH were randomized and...

ea0029p654 | Diabetes | ICEECE2012

Diabetic peripheral arterial occlusive disease is associated with microvascular complications but coronary atherosclerosis might not be associated with them

Tesic D. , Kovacev-Zavisic B. , Mitrovic M. , Popovic V. , Vukovic B. , Novakovic-Paro J.

Background and aims: The distribution of arterial occlusive disease is not fully explained in diabetes. The aim of this study was to examine the prevalence of CHD and PAD in diabetic patients complicated by abnormal test of distal autonomic function (Neuropad®) and large fibre neuropathy.Materials and Methods: 237 patients were analysed, M/F 111/126, age (mean±SD) 61.3±9.5years (ys), diabetes duration 16.4±10.6ys., type 1 n=22 (9.3%),...

ea0029p1429 | Pituitary Clinical | ICEECE2012

Synergistic effects of combined stimulation with CRH+ghrelin on ACTH and cortisol responses in patients with Cushing’s disease: a pilot study

Miljic D. , Doknic M. , Pekic S. , Stojanovic M. , Damjanovic S. , Popovic V.

Background: Several stimulatory tests for differential diagnosis of ACTH dependent CushingÂ’s syndrome are avilable, CRH being the most valuable test in patients with CushingÂ’s disease (CD). Exaggerated responses to ghrelin have also been shown in patients with CD mainly due to overexpression of GHS receptors on corticotrope tumor cells. However, the effects of combined stimulation with CRH+ghrelin on ACTH and cortisol secretion have not been tested before in these pa...

ea0029p1430 | Pituitary Clinical | ICEECE2012

Bone turnover in patients with active acromegaly in relation to glucose metabolism

Pekic Djurdjevic S. , Miljic D. , Stojanovic M. , Doknic M. , Jeremic V. , Jovanovic M. , Popovic V.

Objective: There is a complex cross-talk between bone and glucose metabolism. The surrogate markers of bone metabolism are osteocalcin (for bone formation) and CTx (for bone resorption). The osteoblast-derived protein osteocalcin has recently been shown to affect glucose homeostasis.Aim of the study: To investigate the relationship between markers of bone metabolism and parameters reflecting bone composition, glucose homeostasis and insulin resistance in...

ea0026p46 | Endocrine disruptors | ECE2011

Bone remodeling parameters and bone mass in patients with schizophrenia treated with long-acting injectable risperidone

Doknic M , Bojovic N Maric , Pekic S , Britvic D , Damjanovic A , Gasic M Jasovic , Popovic V

Introduction: Studies suggest that schizophrenia and prolactin raising antipsychotics, one of them being risperidone, may be associated with low bone mass. On the other hand, weight gain as a consequence of antipsychotics in these patients may be the protective factor against osteoporosis.Objective: Determine bone remodeling parameters and bone mass in patients with schizophrenia treated with long-acting injectable risperidone (LAIR) under naturalistic c...

ea0026p173 | Neuroendocrinology | ECE2011

Glucose homeostasis in GH deficient adults not treated with GH: more than 10 year follow-up

Djurdjevic S Pekic , Doknic M , Stojanovic M , Miljic D , Djurovic M , Stojanoska M Medic , Popovic V

Study objective: We investigated prevalence of impaired glucose homeostasis in a large cohort of adult patients with GH deficiency (GHD), not treated with GH after more than 10 years of follow-up.Design: Seventy-one adult GHD patients (30 males, 41 females; mean age 48.3±2.0 years, mean BMI 28.8±0.7 kg/m2, GH deficient for 10.2±1.2 years) were evaluated. Ninety percent of patients had multiple pituitary hormone deficiencies whic...

ea0010oc21 | Young Endocrinologist session | SFE2005

Neuroendocrine response to ghrelin in patients with anorexianervosa (AN)

Miljic D , Pekic S , #Djurovic|# , Doknic M , Milic N , Casanueva F , Ghatei|V##Popovic M

Ghrelin stimulates growth hormone (GH), prolactin (PRL) and cortisol release in rodents and healthy humans.Aim: to determine the effects of ghrelin on neuroendocrine response in patients with AN in this cross-sectional hospital based study, approved by the Local Ethical Committee. Twenty-five young women were studied: AN with very low body weight (BMI 12.0±0.4 kg/m2), partially recovered AN (PRAN 17.2±1.3 kg/m2) and consti...

ea0007p121 | Endocrine tumours and neoplasia | BES2004

Discrepancies between current consensus criteria for cure after transsphenoidal surgery for acromegaly

Petakov M , Djurovic M , Miljic D , Doknic M , Pekic S , Popovic V , Damjanovic S

The short-term results of transsphenoidal surgery as initial treatment for acromegaly were analyzed according to consensus defining the criteria for cure of acromegaly.Thirty nine newly diagnosed patients with acromegaly (20 females and 19 males, mean age 46.9 plus/minus 1.4 years, range 29-66 yrs), underwent transsphenoidal pituitary adenomectomy by the same neursurgeon. Patients have been assessed postoperatively at 8 weeks (GH after 75 g oral glucose ...

ea0029p308 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Association of PON-1 activity and other anti-oxidative enzymes with long-chain fatty acids profile in T2DM

Rasic-Milutinovic Z. , Tica J. , Gluvic Z. , Popovic-Radinovic V. , Vujovic M. , Lackovic M. , Samardzic V. , Popovic T. , Glibetic M.

Background: Serum paraoxonase-1 (PON-1) activity is decreased in clinical conditions associated with low high density-cholesterol (HDL-C), increased lipid peroxidation and low-grade chronic inflammation such as in type 2 diabetes mellitus (T2DM). Although many studies have shown that some poly unsaturated fatty acids (PUFA) modulate cardiovascular risk in T2DM, until now there is no data about the association of any fatty acid (FA) with PON-1 activity. This study aims to inves...