Searchable abstracts of presentations at key conferences in endocrinology

ea0082wb4 | Workshop B: Disorders of growth and development | SFEEU2022

Activating mutation of the Calcium sensing receptor as a cause of hypocalcemia

Qamar Sulmaaz , Baldeweg Stephanie

Introduction: Calcium sensing receptor (CaSR) plays a role in calciotropic processes by regulating parathyroid hormone secretion and urinary calcium excretion. Activating mutation of the CaSR, with heterozygous gain in function, causes autosomal dominant hypocalcaemia 1 (ADH1), a rare disorder with a prevalence of 3.9 per 100,000. Aggressive treatment to normalise serum calcium causes nephrocalcinosis and hypercalcaemia. We present a case of a 27-year-old female with CaSR muta...

ea0075p12 | Pituitary and neuroendocrinology | EYES2021

Apoplexy in a patient with a Plurihormone Pituitary adenoma with corticotroph predominance

Qamar Sulmaaz , Naeem Ammara , Baldeweg Stephanie

Introduction: Silent corticotroph adenomas(SCA) are defined as pituitary adenomas showing positive staining for adrenocorticotrophic hormone in immunohistochemical studies not associated with clinical/laboratory features of hypercortisolaemia. We report a case of SCA in a 61-year-old man, who presented with pituitary apoplexy.Case presentation: Patient presented with persistent diplopia of 3 months duration, associated with severe headache for 1 week. He...

ea0070aep1063 | Hot topics (including COVID-19) | ECE2020

Neuromyelitis optica presenting as intractable hiccoughs and SIADH: A Case Report

Qamar Sulmaaz , Armeni Eleni , Mainuddin Md , Hotton Gary , Menon Ravi

Neuromyelitis Optica (NMO) is a neuro-inflammatory condition usually presenting with optic nerve and spinal cord events, caused by autoimmunity to Aquaporin 4 (AQ4) channels in the central nervous system (CNS). The high density of AQ4 channels in the hypothalamus and area postrema mean that NMO can occasionally present with atypical features. We present a 56-year old South Asian man, who presented with hiccoughs and Syndrome of inappropriate antidiuretic hormone (SIADH ) and w...

ea0070ep69 | Bone and Calcium | ECE2020

Coexisting primary hyperparathyroidism and plasma cell dyscrasias – A case series

Qamar Sulmaaz , Armeni Eleni , Rayanagoudar Girish , Menon Ravi

Introduction: Coexistence of primary hyperparathyroidism and plasma cell dyscrasias such as multiple myeloma and monoclonal gammopathy of uncertain significance (MGUS) is rare. This can cause diagnostic uncertainty regarding the aetiology and relative contribution of each disorder to hypercalcaemia. We present a series of five individuals with this combination.Case series: All five patients were referred to the endocrine clinic with hypercalcaemia. The s...

ea0077p4 | Adrenal and Cardiovascular | SFEBES2021

The saline infusion test, but not the captopril challenge test, is associated with intra-test hypertension and hypokalaemia in patients being investigated for primary aldosteronism

Mourougavelou Vishnou , Qamar Sulmaaz , Akker Scott , Druce Maralyn , Sze Candy , Waterhouse Mona , Chung Teng-Teng , Drake William , O’Toole Sam

Background: Primary aldosteronism (PA) is a common, curable and high-risk subset of hypertension, mandating detection. In all but the most severe cases, learned society guidelines recommend confirmatory testing. Whilst a variety of confirmatory tests exist, data describing their safety are limited. Concerns centre around the potential of some tests to precipitate hypokalaemia or a hypertensive emergency in a patient with PA on sub-optimal anti-hypertensive medication. In this ...

ea0070aep1049 | Hot topics (including COVID-19) | ECE2020

Diabetic emergencies during COVID-19 –A multi-centre experience

Qamar Sulmaaz , Aziz Umaira , Nasir Sadia , Armeni Eleni , Zosmer Maya , Joseph Tobin , Crawley Eleanor , Tutty Susan , Lynch Jo , Bouloux Pierre , Yousseif Ahmed , Khan Sidrah , Menon Ravi , Nethaji Chidambaram , Karra Efthimia

Introduction: Diabetes mellitus is as a major contributor to disease severity and mortality in patients with Covid-19 infection, as the estimated increase in risk of death in hospitalised patients is 3.5-times (for T1DM) and 2.03-times (for T2DM).This retrospective analysis recruited 35 patients from three London hospitals who presented with diabetic emergencies i.e. diabetic ketoacidosis (DKA), Hyperglycaemic hyperosmolar state( HHS), presence of ketone...