Endocrine Abstracts

Insulin resistance and its resultant hyperinsulinaemia seem to play a pivotal role in the pathogenesis of polycystic ovary syndrome (PCOS), which apart from its cosmetic and metabolic consequences also lead to fertility problems. Therefore, metformin – a biguanide used as the first line of pharmacotherapy in patients with type 2 diabetes mellitus (T2DM), is often prescribed to women with PCOS in order to decrease the consequences of hyperinsulinaemia and to restore ovulat...

Background: Polycystic ovary syndrome (PCOS) is a heterogenous endocrinopathy commonly diagnosed in reproductive age women, predisposing to the development of metabolic disturbances. However, the mechanisms underlying the connection between PCOS and metabolic disorders are still not well understood. The aim of the study was to investigate amino acid (AA) profile in women with PCOS and to assess its relation with metabolic disturbances.Methods: 326 women:...

Introduction: Subclinical hypothyroidism (SCH) can impair concentration and memory skills. If this is a case among adolescents it may impair learning abilities, which in turn may be the cause of poorer performance on various tests and exams. Therefore, the aim of this study was to evaluate the prevalence of SCH in teenage girls attending the gymnasia in the city of Starogard Gdański.Material and methods: In total 487 girls (age range 11.5–14.7 ...

Plasticisers such as bisphenol A (BPA), bisphenol S (BPS), and phthalates (PAE) are commonly used in daily life in electronic equipment, cans, plastic food containers, and bottles. These substances can interact with oestrogen receptors as well as androgen receptors and therefore they are called endocrine disrupting chemicals (EDC). The aim of this study was to evaluate serum concentrations of BPA, BPS, and selected PAE in healthy women and women with polycystic ovary syndrome ...

Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in women of reproductive age, that lead to infertility, type 2 diabetes and coronary heart disease.Bisphenol A (BPA) is one of the most abundant chemicals produced worldwide and is used as a plasticizer in daily life. Nowadays it is also well know that it can interact with estrogen receptors, androgen receptors and peroxisome proliferator-activated receptors γ (PPARγ). Therefore...