Endocrine Abstracts

Background: Hyperprolactinemia, caused by chronic use of antipsychotics, is associated with impaired bone density and increased risk of fractures. We examined if calcium and vitamin D supplementation have influence on Prlr gene expression in the duodenum, vertebrae and kidneys in female rats with sulpiride-induced hyperprolactinemia.Methods: Wistar female rats 21 weeks old were divided into: Group S: 10 rats that were intramuscular administrated Sulpirid...

Introduction: The gut microbiota plays an important role in host metabolism, immunity, digestibility and even a behavior. Candida spec. is common resident of the gastrointestinal tract and integral part of the microbiota. Number of 101 to 103 fungal cells per g stool are considered as normal range. However, when mucosal surface is disrupted or host immunity is compromised, life-threatening invasive infection can ensue.Objec...

Introduction: Primary hypothyroidism, as a clinical syndrome caused by insufficiency or inefficacy of thyroid hormones, significantly influences on patients’ quality of life (QoL). Accelerated atherosclerosis induces increased cardiovascular morbidity and mortality rates in hypothyroid patients. Serum NO2 levels, the stable NO metabolites, are among well-known markers for endothelial dysfunction and atherosclerosis in hypothyroidism. We examined the correlation between se...