Searchable abstracts of presentations at key conferences in endocrinology

ea0063p599 | Diabetes, Obesity and Metabolism 2 | ECE2019

Testosterone restores metabolic syndrome-induced impairement in physical activity by ameliorating skeletal muscle fiber metabolism

Morelli Annamaria , Sarchielli Erica , Comeglio Paolo , Filippi Sandra , Cellai Ilaria , Guarnieri Giulia , Rastrelli Giulia , Vignozzi Linda , Maggi Mario

Background: Metabolic syndrome (MetS) is a clustering of metabolic and cardiovascular risk factors, with insulin resistance being one of the main components. In male, MetS is also associated to hypogonadotropic hypogonadism. Lifestyle modifications (e.g. physical activity) could prevent or considerably reduce MetS progression, however the ability to perform physical activity is often impaired in MetS subjects.Aim: Considering the known trophic role of T ...

ea0063p1125 | Reproductive Endocrinology 2 | ECE2019

Both comorbidity burden and low testosterone can explain symptoms and signs of testosterone deficiency in men consulting for sexual dysfunction

Rastrelli Giulia , Corona Giovanni , Maggi Mario

Background: Low testosterone (T) is frequent in men with chronical illnesses. The clinical features of T deficiency (TD) overlap with those of chronic diseases. The aim of this study is to evaluate the relative contribution of chronic disease score (CDS) and low T to the presence of TD symptoms.Methods: A consecutive series of 3862 men (aged 52.1±13.1 years) consulting for sexual dysfunction was studied. Several clinical and biochemical parameters w...

ea0063p1126 | Reproductive Endocrinology 2 | ECE2019

Hormonal predictors of pathologic findings at magnetic resonance imaging in secondary hypogonadal men

Cipriani Sarah , Corona Giovanni , Maggi Mario , Rastrelli Giulia

Introduction: Secondary hypogonadism (sHG) is the most common form of hypogonadism. sHG can arise from any dysregulation of hypothalamic-pituitary (HP) axis due to functional or organic disorders. HP organic disorders are often diagnosed using pituitary magnetic resonance imaging (MRI). However, MRI is an expensive and not widespread exam and it cannot be routinely offered to all sHG patient. The Endocrine Society guidelines suggest MRI scan in sHG men with total testosterone ...

ea0035p179 | Cardiovascular Endocrinology & Lipid Metabolism | ECE2014

Characteristics of compensated hypogonadism in patients with sexual dysfunction

Corona Giovanni , Maseroli Elisa , Rastrelli Giulia , Maggi Mario

Introduction: In the last few years the view that subclinical endocrine disorders represent milder forms of the clinically overt disease has emerged. Accordingly, it has been proposed that compensated hypogonadism represents a genuine clinical subgroup of individuals with late onset hypogonadism (LOH). The aim of the present study is to investigate the association of compensated hypogonadism with clinical and psychological characteristics of male subjects complaining for sexua...

ea0032p657 | Male reproduction | ECE2013

Impaired masturbation induced erections: a new cardiovascular risk factor for male subjects with sexual dysfunction

Rastrelli Giulia , Boddi Valentina , Corona Giovanni , Forti Gianni , Maggi Mario

Introduction: Erectile dysfunction (ED) is considered an early surrogate marker of silent, or even overt, cardiovascular diseases (CVD). However, epidemiological studies take into account only sexual intercourse-related erections. Although autoeroticism is a very common practice, data on masturbation-induced erections as a possible predictor of major adverse cardiovascular events (MACE) are lacking.Aim: To evaluate the clinical correlates of impaired mas...

ea0035p207 | Cardiovascular Endocrinology & Lipid Metabolism | ECE2014

Flaccid penile acceleration as a marker of cardiovascular risk in men without classical risk factors

Rastrelli Giulia , Corona Giovanni , Lotti Francesco , Aversa Antonio , Bartolini Marco , Mancini Mario , Mannucci Edoardo , Maggi Mario

Introduction: Conventional cardiovascular (CV) risk factors identify only half of subjects with incident major adverse CV events (MACE). Hence new markers are needed in high CV risk subjects, as those with erectile dysfunction (ED). A role for dynamic peak systolic velocity (D-PSV) at penile color Doppler ultrasound (PCDU) has been suggested, but it is operator-dependent and time-consuming. Flaccid penile acceleration (FPA) is a PCDU parameter that reflects PSV, the systolic r...

ea0035p697 | Male reproduction | ECE2014

Metformin in vitro and in vivo increases adenosine signalling in rabbit corpora cavernosa

Vignozzi Linda , Filippi Sandra , Comeglio Paolo , Cellai Ilaria , Rastrelli Giulia , Morelli Annamaria , Mannucci Edoardo , Maggi Mario

Introduction: In subjects with erectile dysfunction (ED) responding poorly to sildenafil, metformin was reported to improve erections.Aims: To investigate metforminÂ’s mechanism of action on erectile function, particularly focusing on adenosine (ADO), and NO signalling in an animal model of high fat diet (HFD)-induced metabolic syndrome (MetS).Methods: In vitro contractility studies of penile strips. Penile expression ...

ea0035p706 | Male reproduction | ECE2014

Relationship of testis size and LH levels with incidence of major adverse cardiovascular events in older men with sexual dysfunction

Rastrelli Giulia , Corona Giovanni , Lotti Francesco , Boddi Valentina , Mannucci Edoardo , Maggi Mario

Introduction: Measurement of testis volume (TV) is a reliable clinical procedure that predicts reproductive fitness. However, the role of TV in overall and cardiovascular (CV) fitness has never been studied.Aim: The study aims to analyze the clinical correlates of TV in patients with sexual dysfunction (SD) and to verify the value of this parameter and its determinants (i.e., luteinizing hormone (LH) levels) in predicting major adverse CV events (MACE).<...

ea0035p707 | Male reproduction | ECE2014

Lack of sexual privacy affects psychological and marital domains of male sexual dysfunction

Boddi Valentina , Fisher Alessandra Daphne , Rastrelli Giulia , Corona Giovanni , Maggi Mario

Introduction: Sexual dysfunctions (SD) are dictated by predisposing, precipitating, maintaining, and contextual factors, the latter of which can help sexual problems to emerge. Even if the lack of sexual privacy is one of the most common contextual issues, it has not been extensively studied.Aim: Investigation of sexual privacy in a large sample of men consulting for SD.Methods: A consecutive series of 3736 men, attending the Outpa...

ea0032p658 | Male reproduction | ECE2013

PSA as a marker of testosterone biological activity

Rastrelli Giulia , Corona Giovanni , Maseroli Elisa , Monami Matteo , Mannucci Edoardo , Forti Gianni , Maggi Mario

Objective: To verify whether, in a large sample of male subjects seeking medical care for sexual dysfunction (SD), prostate-specific antigen (PSA) might represent a reliable marker of testosterone bioactivity, even downstream to its receptor binding.Design: Cross-sectional study.Methods: A consecutive series of 3156 patients attending our Unit for SD studied. Among them, only subjects without history of prostate disease and with PS...