Searchable abstracts of presentations at key conferences in endocrinology

ea0020p287 | Clinical case reports and clinical reports | ECE2009

Progression of endocrine hypofunction: a case of polyglandular autoimmune syndrome type 2

Ratnasabapathy Risheka , De Silva Akila

A 52-year-old, previously well Indian lady was admitted in May 2008 with pneumonia. Concurrently, she was diagnosed with diabetes mellitus (blood glucose 20 mmol/l). Her BMI was 19 kg/m2 and she was initially commenced onto sulphonylurea therapy. She had a further admission in July 2008 with dizzy episodes, falls, postural hypotension (systolic postural drop 75 mmHg) and erratic blood glucose levels (range 1.1–30 mmol/l). Blood ketones were 3.6 mmol/l without a...

ea0035p920 | Pituitary Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2014

A case or recurrent pituitary apoplexy

Deb Tanya , Sounderajah Viknesh , Ratnasabapathy Risheka , Antonelou Marilina , Baburaj Rajee , Edwards Mark

A 35-year old female presented with a 5 day history of headache, diplopia and reduced visual acuity preceded by 6 months of lethargy and weight gain. Visual field testing revealed left temporal hemianopia. Magnetic resonance imaging (MRI) showed a benign pituitary adenoma with intra-tumoural haemorrhage compressing the optic chiasm. Neurosurgical opinion advised on transphenoidal surgery. However, in view of spontaneous resolution of diplopia and recovery of peripheral vision,...

ea0070ep291 | Pituitary and Neuroendocrinology | ECE2020

Cabergoline treatment: The ethics around side effects

Ratnasabapathy Risheka , Patel Bijal , Qayum Ambreen , Zaman Shamaila , Behary Preeshila , Meeran Karim , Martin Niamh

Cabergoline has long been used to treat prolactinomas for symptomatic, radiological and biochemical resolution of pituitary tumours. As clinicians we are well-versed at screening for physical side effects, but are we holistic enough? We present two cases illustrating the damaging social consequences of cabergoline treatment for prolactinomas.Case 1A 49-year-old married father of two presented with a seizure in April 2018. MRI showe...

ea0038p352 | Reproduction | SFEBES2015

I.v. and s.c. infusions of kisspeptin-54 stimulate gonadotrophin release similarly in healthy women

Narayanaswamy Shakunthala , Jayasena Channa , Ng Noel , Ratnasabapathy Risheka , Papadopoulou Deborah , Prague Julia , Abbara Ali , Comninos Alexander , Bloom Stephen , Dhillo Waljit

Background: Kisspeptin stimulates hypothalamic GnRH secretion resulting in gonadotrophin release and has the potential as a future therapeutic for infertility. Previous studies have observed that kisspeptin increases LH and to a lesser degree FSH when administered to healthy women, which may limit its therapeutic potential. However, studies in women with hypothalamic amenorrhoea show that i.v. infusions of kisspeptin-54 stimulated both LH and FSH equally. Chronic s.c. infusion...

ea0031oc1.8 | Young Endocrinologists prize session | SFEBES2013

Kisspeptin advances ovulation in healthy women

Comninos Alexander , Jayasena Channa , Nijher Monica , Abbara Ali , De Silva Akila , Veldhuis Johannes , Ratnasabapathy Risheka , Izzi-Engbeaya Chioma , Lim Adrian , Patel Daksha , Ghatei Mohammad , Bloom Steve , Dhillo Waljit

Background: The KISS1 gene, is a critical regulator of normal reproductive function. In humans, KISS1 deletion results in a failure to go through puberty while activating mutations result in central precocious puberty. Administration of kisspeptin induces ovulation in rodents and sheep. However chronic exposure to exogenous kisspeptin-54 leads to profound tachyphylaxis in women with hypothalamic amenorrhoea. It is not known whether exogenous kisspeptin can alter the m...

ea0031p307 | Pituitary | SFEBES2013

Kisspeptin-54 administration stimulates LH pulsatility in women with hypothalamic amenorrhoea

Abbara Ali , Jayasena Channa , Ratnasabapathy Risheka , Comninos Alexander , Nijher Monica , Ganiyu-Dada Zainab , Mehta Amrish , Todd Catriona , Ghatei Mohammad , Bloom Stephen , Dhillo Waljit

Introduction: Kisspeptin-54 is a recently identified hormone, which potently stimulates GnRH secretion within the hypothalamus. Women with hypothalamic amenorrhoea (HA, hypogonadotrophic hypogonadism associated with low body weight) have reduced LH pulsatility causing amenorrhea and infertility. We have previously demonstrated that exogenous administration of kisspeptin-54 acutely stimulates gonadotrophin secretion in women with HA. However, it is not known whether exogenous k...

ea0044oc6.1 | Pregnancy and Reproductive Health | SFEBES2016

Two doses of kisspeptin improve oocyte maturation and implantation rates compared to a single kisspeptin injection during IVF treatment

Abbara Ali , Clarke Sophie , Islam Rumana , Prague Julia , Comninos Alexander , Narayanaswamy Shakunthala , Papadopolou Deborah , Roberts Rachel , Nesbitt Alexander , Izzi-Engbeaya Chioma , Vimalesvaran Sunitha , Ratnasabapathy Risheka , Salim Rehan , Lavery Stuart , Bloom Stephen , Trew Geoffrey , Dhillo Waljit

Background: In vitro fertilisation is an effective therapy for infertility, but can result in the potentially life-threatening complication, Ovarian Hyper-Stimulation Syndrome (OHSS). We have previously reported that a single injection of kisspeptin results in an LH surge of ~12–14 hrs duration, sufficient to safely induce oocyte maturation, but eliminate OHSS. However, the physiological LH surge in a normal menstrual cycle has a plateaux lasting 24–28 hrs. ...

ea0059oc3.5 | Obesity &amp; diabetes | SFEBES2018

Hypothalamic arcuate glucokinase and its downstream pathways are critical in glucose homeostasis

Ratnasabapathy Risheka , Ma Yue , Izzi-Engbeaya Chioma , Nguyen-Tu Marie-Sophie , Richardson Errol , Hussain Sufyan , De Backer Ivan , Holton Christopher , Norton Mariana , Carrat Gaelle , Schwappach Blanche , Rutter Guy A , Dhillo Waljit S , Gardiner James V

As the nation gets fatter, the incidence of diabetes is also rising. The brain is now emerging as a critical mediator of blood sugar control, re-directing focus away from the traditional pancreas-centred model. The enzyme glucokinase (GK) acts as a glucose sensor in many tissues including glucose-sensitive neurones within the hypothalamic arcuate nucleus. However, the role of GK here is unclear. We investigated the role of arcuate GK in glucose homeostasis in both healthy and ...