Searchable abstracts of presentations at key conferences in endocrinology

ea0081p666 | Pituitary and Neuroendocrinology | ECE2022

Inferior petrosal sinus sampling in differential diagnosis of adrenocorticotropic hormone (ACTH)-dependent cushing’s syndrome: a tertiary centre experience

Araujo Catia , Martins Ferreira Mafalda , Reis Guiomar Joana , Moreno Carolina , oliveira patricia , Baptista Carla , Gomes Leonor , rodrigues dircea , Paiva Isabel

Introduction: Inferior petrosal sinus sampling (IPSS) has been considered to be the gold standard for differential diagnosis of Cushing’s Disease (CD) and ectopic ACTH secretion (EAS).Aim: To describe the experience of our centre in performing IPSS, its safety and efficacy; assess remission rates from transphenoidal surgery and clinical course; approach to the difficulty in the etiological diagnosis of ACTH-dependent Cushing’s Syndrome.<p c...

ea0073ep26 | Calcium and Bone | ECE2021

Challenges in diagnosis and treatment of Parathyroid Carcinoma – case report

Reis Guiomar Joana , Moreno Carolina , Melo Miguel , Lúcia Fadiga , Diana Alexandra Festas Silva , Paiva Isabel

IntroductionParathyroid carcinoma (CaPa) is an extremely rare cause of primary hyperparathyroidism. Patients with CaPa usually present severe hypercalcemia with abrupt bone and renal diseases, neurologic manifestations and gastrointestinal symptoms. However, sometimes the presentation is insidious with nonspecific symptoms and mild hypercalcemia. Surgery is the only curative treatment and after surgery close monitoring of calcium levels are necessary due...

ea0063p728 | Pituitary and Neuroendocrinology 2 | ECE2019

Acromegaly in McCune-Albright Syndrome: case report

Reis Guiomar Joana , Moreno Carolina , Paiva Isabel , Miguel Cardoso Luis , Cunha Nelson , Catarino Diana , Fadiga Lucia , Festas Silva Diana , Pedro Freitas Joao , Bastos Margarida

Introduction: McCune-Albright syndrome (MAS) consists of at least two of the following three conditions: polyostotic fibrous dysplasia (PFD), café-au-lait skin pigmentation and autonomous endocrine hyperfunction. The most common form of autonomous endocrine hyperfunction is precocious puberty, but other syndromes may be present, including acromegaly, hyperthyroidism, and Cushing syndrome. Acromegaly is seen in approximately 20% of patients with MAS. Treatment opt...

ea0070aep789 | Reproductive and Developmental Endocrinology | ECE2020

X-Linked Adrenoleukodystrophy: Report of an atypical case

Fadiga Lúcia , Saraiva Joana , Catarino Diana , Reis Guiomar Joana , Alexandra Festas Silva Diana , Lavrador Mariana , Esteves Ferreira Sara , do Carmo Macário Maria , Paiva Isabel

Introduction: X-linked adrenoleukodystrophy (X-ALD) is caused by a mutation in the ABCD1 gene, which encodes for a peroxisomal very long chain fatty acid (VLCFA) transporter. Clinically, X-ALD can present a wide spectrum of phenotypes, being the most frequent Adrenomyeloneuropathy, with ataxia, spastic paraparesis, sexual and sphincter dysfunction. Adrenocortical insufficiency (AI) occurs mainly in paediatric age and it can be the first manifestation of the disease in some cas...

ea0070ep21 | Adrenal and Cardiovascular Endocrinology | ECE2020

Singularities of the undertreatment of congenital adrenal hyperplasia in adults

Lavrador Mariana , Lages Adriana , Catarino Diana , Fadiga Lúcia , Alexandra Festas Silva Diana , Reis Guiomar Joana , Vieira Inês , Barros Luísa , Paiva Isabel

Introduction: Congenital Adrenal Hyperplasia (CAH) results from enzymatic defects caused by autossomal recessive hereditary mutations characterized by deficient cortisol synthesis and, in most cases, increased androgen synthesis. 90–95% of the cases are originated by deficits in 21-hydroxylase and, in about 75% of the cases, there is evidence of mineralocorticoid deficiency.Case report: A 37-year-old patient was referred to an Endocrinology departm...

ea0070ep471 | Thyroid | ECE2020

Risk factors in graves’ disease recurrence after treatment with radioactive iodine

Reis Guiomar Joana , Lemos Luís , Moreno Carolina , Catarino Diana , Fadiga Lúcia , Silva Diana , Vieira Inês , Lavrador Mariana , Costa Gracinda , Paiva Isabel

Introduction: Radioactive iodine (131I) therapy is a safe and cost-effective choice in Graves’ disease (GD). Usually only one treatment with 131I is sufficient, however, individual characteristics of the disease can lead to its recurrence. The aim of this study is to determinate the risk factors that influence the recurrence of GD after 131I.Materials and methods: Retrospective cohort study in 528 patients with GD who did <sup...

ea0070aep116 | Adrenal and Cardiovascular Endocrinology | ECE2020

Adjuvant mitotane therapy: Predictive factors of response in adrenocortical carcinoma

Alexandra Festas Silva Diana , Reis Guiomar Joana , Catarino Diana , Moreno Carolina , Gomes Leonor , Ribeiro Cristina , Fadiga Lúcia , Vieira Inês , Lavrador Mariana , Caetano Rui , Figueiredo Arnaldo , Paiva Isabel

Introduction: Adrenocortical carcinoma (ACC) is a rare and aggressive tumor, with a poor prognosis and median survival of 3–4 years. Complete surgical resection is the only possibility of cure. The rate of post-surgical recurrence is high, so adjuvant treatment with mitotane plays a key role.Objectives: To evaluate predictive factors of response to adjuvant treatment with mitotane in monotherapy in patients that underwent surgical resection of ACC....

ea0073pep4.7 | Presented ePosters 4: Reproductive and Developmental Endocrinology | ECE2021

Functional ovarian reserve in women with infertility and euthyroidism: what is the role of thyroid autoimmunity?

Alexandra Festas Silva Diana , Carvalho Tânia , Maresch Ângela , Catarino Diana , Fadiga Lúcia , Reis Guiomar Joana , Gomes Leonor , Leitão Fátima , Cortesão Paulo , Almeida Santos Teresa , PAIVA Isabel

IntroductionThyroid dysfunction is the most common endocrine disorder in women of childbearing age, and is associated with menstrual irregularities, anovulation and infertility. Whether it is thyroid function and/or thyroid autoimmunity (AI) that affects functional ovarian reserve remains to be clarified.AimTo evaluate the association between functional ovarian reserve and thyroid AI in women with infertility...