Searchable abstracts of presentations at key conferences in endocrinology

ea0041ep985 | Thyroid (non-cancer) | ECE2016

Clinical, imaging and cytological differences between palpable and non-palpable thyroid nodules

Silva Joao , Paiva Sandra , Ribeiro Cristina , Melo Miguel , Gomes Leonor , Bastos Margarida , Carrilho Francisco

Introduction: The prevalence of palpable nodules varies between 3–7% and nodules diagnosed by ultrasonography between 20–76%. According to the American Thyroid Association’s guidelines it isn’t recommended to perform routine thyroid ultrasound for thyroid nodules diagnosis, unless they are palpable or there are any risk factors.Objective: Evaluation of sonographic and cytological differences between palpable and non-palpable thyroid n...

ea0032p40 | Adrenal cortex | ECE2013

Autoimmune polyglandular syndrome on a cohort of patients with primary adrenocortical insufficiency

Gouveia Sofia , Ribeiro Cristina , Alves Marcia , Saraiva Joana , Moreno Carolina , Guelho Daniela , Carrilho Francisco

Introduction: On average, 40 to 50% of the patients with autoimmune adrenocortical insufficiency will eventually develop an autoimmune polyglandular syndrome (APS). Our aim was to characterize a population with primary adrenocortical insufficiency (AI) and determine the prevalence of other autoimmune disorders that might establish the diagnosis of APS.Materials and methods: We included patients with primary AI under surveillance at our Department. Those ...

ea0032p1136 | Thyroid cancer | ECE2013

Thyroglobulin measurement in fine needle aspirates from cervical lymph nodes

Ribeiro Cristina , Paiva Sandra , Melo Miguel , Gouveia Sofia , Leitao Fatima , Carrilho Francisco

Introduction: Thyroglobulin (TG) measurement in fine needle aspirates cytology (FNAC) needle washout has become an important method for diagnostic of cervical lymph nodes, particularly in patients with differentiated thyroid cancers, but also in some patients before the diagnostic. We report some clinical cases to confirm its importance in these situations.Patients and methods: In our department we use this method since 2007. We report seven patients wit...

ea0022p101 | Bone/Calcium | ECE2010

Fine needle aspiration of parathyroid gland with PTH analysis in washouts: is it worthy?

Melo Miguel , Ribeiro Cristina , Paiva Sandra , Vieira Alexandra , Carrilho Francisco , Carvalheiro Manuela

Introduction: Primary hyperparathyroidism (PHPT) is the most common cause of hypercalcaemia in the outpatient setting. Surgical remove of an adenoma or hyperplastic glands results in cure, but an accurate localization, preoperative whenever possible, is essential for success. Taking into consideration that parathyroid carcinoma is a rare event, FNA of parathyroid glands, complemented by PTH measurement in washouts (FNA/PTH), may be a useful tool in the diagnostic workout.<...

ea0014oc4.3 | Neuroendocriology basis | ECE2007

Absence of germline AIP mutations in early onset sporadic somatotropinomas

Gomes Leonor , Prazeres Hugo , Paiva Isabel , Ribeiro Cristina , Rebelo Olinda , Martins Teresa , Lacerda Manuela , Carvalheiro Manuela

Objective: The pathogenesis of pituitary tumours is still incompletely understood. Somatotropinomas occur both sporadically and in the context of familial syndromes, such as multiple endocrine neoplasia type 1 (MEN1), Carney complex (CNC) and isolated familial somatotropinoma (IFS). Recently, germline mutations were reported in AIP (aryl hydrocarbon receptor interacting protein) gene in Finish and Italian families and in Finish patients with apparently sporadic pituitar...

ea0056p998 | Clinical case reports - Thyroid/Others | ECE2018

Type 1 diabetes mellitus and sorafenib: coincidence or consequence?

Ribeiro Cristina , Catarino Diana , Oliveira Diana , Saraiva Joana , Melo Miguel , Paiva Sandra , Carrilho Francisco

Introduction: Differentiated thyroid carcinoma is usually associated with a good prognosis. However, some of these tumors (5%) are radioiodine refractory and have different progression, associated with poor prognosis. In these situations, some tyrosine kinase inhibitors (TKI) can be used. We present a clinical case showing the difficulties in the follow-up and treatment of these patients.Clinical case: A 60 years old woman, with a “multicentric papi...

ea0032p1101 | Thyroid cancer | ECE2013

Thyroglobulin levels in the washout of lymph node fine-needle aspirate on patients with previous history of differentiated thyroid cancer

Gouveia Sofia , Ribeiro Cristina , Paiva Sandra , Alves Marcia , Saraiva Joana , Moreno Carolina , Guelho Daniela , Leitao Fatima , Carrilho Francisco

Introduction: Our aim was to determine the comparable value of thyroglobulin in the washout of lymph node fine-needle aspirate (FNATg) and fine-needle aspiration biopsy (FNAB).Materials and methods: We included 29 patients (37 FNAB) with history of differentiated thyroid cancer who underwent total thyroidectomy and were found to have suspicious cervical lymph nodes during follow-up. The referred population was evaluated on what concerns to gender, age, s...

ea0026p229 | Pituitary | ECE2011

Clinical and subclinical apoplexy in nonfunctioning pituitary tumors: clinical features, management and outcome

Gomes Leonor , Paiva Isabel , Ribeiro Cristina , Santos Jacinta , Vieira Alexandra , Alves Marcia , Gouveia Sofia , Saraiva Joana , Rebelo Olinda , Carvalheiro Manuela

Background: Pituitary apoplexy occurs when a tumor undergoes acute hemorrhage, infarct, or both. This often leads to acute severe symptoms (clinical) but can also occur without them and diagnosed on CT/MRI, surgery, pathology (subclinical). To investigate clinical and subclinical apoplexy in nonfunctioning tumors (n=221) from our database.Design: Retrospective review of clinical presentation, tumor characteristics and outcome of 24 patients, 11 fe...

ea0022p185 | Clinical case reports and clinical practice | ECE2010

Primary biliary cirrhosis and Graves’ disease – combination rarely found

Vieira Alexandra , Paiva Sandra , Ribeiro Cristina , Santos Jacinta , Martinho Mariana , Alves Marcia , Gouveia Sofia , Carrilho Francisco , Carvalheiro Manuela

Introduction: The association of autoimmune diseases in the same individual is common. It is well documented that Graves’ disease (GD) is associated to various autoimmune diseases, including: pernicious anemia, vitiligo, type 1 diabetes, Addison’s disease, systemic sclerosis, myasthenia gravis, Sjogren’s syndrome, rheumatoid arthritis and systemic lupus erythematosus. In addition, primary biliary cirrhosis (PBC) may be associated with rheumatoid arthritis, Sjogr...

ea0022p413 | Endocrine tumours &amp; neoplasia (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Von Hippel-Lindau disease: a case report

Gouveia Sofia , Ribeiro Cristina , Paiva Sandra , Joao Bugalho Maria , Santos Jacinta , Vieira Alexandra , Alves Marcia , Carvalheiro Manuela

Introduction: Von Hippel-Lindau disease (VHLD) is a rare autosomal-dominant syndrome, characterized by the development of multiple cysts and tumours, namely retinal and central nervous system hemangioblastomas, renal cell carcinoma (RCC), phaeochromocytoma, pancreatic endocrine tumours (PET) and endolymphatic sac tumours.Most germinal mutations are missense, related to a high risk for presenting phaechromocytoma (specially if Arg167Trp mutation im...