Endocrine Abstracts

Introduction: Prostate cancer is a neoplasm with high incidence and prevalence in the elderly population in western countries. Androgen deprivation therapy (ADT) has been used in locally advanced or metastatic disease, although most relapse, becoming hormone resistant, which is a poor prognostic event.Objectives: The aim of this study was to evaluate the association of genetic polymorphisms NOS2, GPRC6A, VKORC1, ARGI and ARGII in prostate cancer, particu...

Introduction: The long-term mountain cycling effects on cognitive development for better performance, are still not fully elucidated. Notwithstanding, this type of exercise may induce a link with energy metabolism and sympathetic nervous system. We previously observed that a mountain cycling ultramarathon, induced a comodulatory influence of genetic- and exercise-associated factors on inflammatory and haemoglobin catabolic marker haptoglobin. We hypothesised that inflammatory ...

Introduction: The interaction between bone and energy metabolism may be enhanced in high demanding physical activities. We hypothesize that genetic background may modulate the exercise-associated bone and energy responses of athletes participating of a mountain cycling ultramarathon.Methods: Fifty-five non-professional athletes (mean age 44.8±7.1 years) participating in a 9-day mountain cycling ultramarathon (TransPortugal) were evaluated. Before an...

Introduction: Fat-free mass has a functional significance in aging. The objective of this study was to evaluate the prevalence of underweight in a Portuguese population of centenarians and their relationship with dehydration or sarcopenia.Methods/design: Anthropometric data were obtained using standard procedures from 252 centenarians (100.26±1.99 years), 77.8% women (W). Body composition was assessed by tetrapolar bioimpedance. It was considered de...

Background: Thyroid nodules are present in nearly 60% of the population, representing the most frequent endocrine disease. Fine-needle aspiration (FNA) cytopathology classifies 20%–30% of nodules as indeterminate (Bethesda 3 and 4), a scenario in which molecular tests are recommended aiming to avoid unnecessary diagnostic surgeries.Objective: The aim was to evaluate the diagnostic performance of the new v2 algorithm of mir-THYpe full molecular class...