Searchable abstracts of presentations at key conferences in endocrinology

ea0014p326 | (1) | ECE2007

Partial withdrawal of levothyroxine to stimulate serum thyroglobulin (TG) in the follow-up of differentiated thyroid carcinoma (DTC)

Ianni Francesca , Rota Carlo Antonio , Corsello Salvatore Maria , Rosa Annapina De , Gallo Francesca , Paragliola Rosa Maria , Ingraudo Francesca , Ricciato Maria Pia , Maussier Maria Ludovica , Salvatori Massimo , Pontecorvi Alfredo

Aim: We compared effectiveness of partial withdrawal of levothyroxine (L-T4) to the use of recombinant human TSH (rhTSH) in preparation for Tg testing. We also evaluated clinical aspects and quality-of-life (QOL) during both regimens.Materials and methods: Ten consecutive patients, previously treated with total thyroidectomy and radioiodine ablation for DTC, underwent rhTSH protocol and, after 15 days, reduced their L-T4 dose by 50% for 5 weeks. At the f...

ea0073oc5.5 | Oral Communications 5: Thyroid | ECE2021

Role of miR-139–5p in radioiodine-refractory thyroid cancers

Pecce Valeria , Abballe Luana , Sponziello Marialuisa , Brunelli Chiara , Verrienti Antonella , Annunziata Salvatore , Grani Giorgio , Fadda Guido , Salvatori Massimo , Russo Diego , Durante Cosimo

Radioiodide 131I (RAI) is the therapy of choice for radioiodine-avid differentiated thyroid cancer (DTC). However, 5–15% of DTC patients become RAI refractory (RAIR), and the 10-year survival rate for metastatic disease decreases to 10%. The failure of RAI response is mainly due to the loss of thyroid differentiation, that leads to the loss of expression/function of components of iodide metabolism, first of all the Na/I symporter (NIS). The finding that the MAPK pathway i...

ea0049gp231 | Thyroid Cancer | ECE2017

Management and outcome of bone metastasis from differentiated thyroid carcinoma in the real life: the M.OS.CA.TI. study

Mazziotti Gherardo , Panarotto Maria Beatrice , Arvat Emanuela , Chiti Arturo , Cuocolo Alberto , Dottorini Massimo , Elisei Rossella , Filetti Sebastiano , Filice Angelina , Formenti Anna Maria , Pace Leonardo , Pellegrino Teresa , Nodari Marcello , Salvatori Massimo , Tranfaglia Cristina , Versari Annibale , Frara Stefano , Berruti Alfredo , Giustina Andrea , Giubbini Raffaele

Although differentiated thyroid cancer (DTC) has the third highest propensity to spread to the bone after breast and prostate cancer, there is a paucity of data concerning the treatment of bone metastasis (BM) in this setting. The MOSCATI (Metastasi OSsee da Carcinoma TIroideo) was a multicenter, retrospective study investigating the real-life outcome and management of BM in 143 patients (80 F, 63 M; median age 60 years) with DTC involving 10 specialized cente...