Endocrine Abstracts

Glucose uptake is mediated by a family of glucose transport proteins, which are known to be expressed in specific insulin-sensitive tissues. Magnesium (Mg) is essential for autophosrylation of insulin receptor (INSR) and translocation of glucose transporter 4 (GLUT4) to the plasma membrane to facilitate glucose homeostasis. The specific effect of magnesium on INSR and GLUT4 expression in a diabetic state is however lacking. We conducted this s...

Glucose uptake is mediated by a family of glucose transport proteins, which are known to be expressed in specific insulin-sensitive tissues. Magnesium (Mg) is essential for autophosrylation of insulin receptor (INSR) and translocation of glucose transporter 4 (GLUT4) to the plasma membrane to facilitate glucose homeostasis. The specific effect of magnesium on INSR and GLUT4 expression in a diabetic state is however lacking. We conducted this s...

Background: This study was aimed at examining the association between the fertility parameters and periodontal status of men, with reference to the bacterial culture analysis of the semen and mouth swab, seminal fluid parameters and blood serum parameters.Method: 43 men consisting 30 infertile men as test subject, and 13 fertile men as control aged 30–50 years were selected for this research. Semen samples were analysed to determine microbial presen...

Virtually all biochemical processes in the body require dietary micro-nutrients and imbalance in any of these essential of the diet have the potential to impair metabolic activities. Deficiencies of several mineral nutrients result in stunting, down-regulated immune responsiveness and altered metabolic activities. Appropriate dietary intake of these mineral nutrients can address this deficiency and is currently recommended as part of a lifestyle intervention for the prevention...

Background: A major challenge in the management of breast cancer (BC) is the search for biomarkers that are sensitive and less invasive. miRNAs are reported to be tissue-specific, stable and aberrantly expressed in different tumours, hence their emerging role as potential biomarkers in BC management.Objective: The study focused on developing an in-house method for the detection of mir-145 and mir-21 using SYBR Gre...

Background: A major challenge in the management of breast cancer (BC) is the search for biomarkers that are sensitive and less invasive. miRNAs are reported to be tissue-specific, stable and aberrantly expressed in different tumours, hence their emerging role as potential biomarkers in BC management.Objective: The study focused on developing an in-house method for the detection of mir-145 and mir-21 using SYBR Gre...

Stress defined as a disruption in the normal homeostatic functions of an organism caused by a stressor (a physiological or psychological challenge) is an unavoidable experience of life. Previous studies suggest that stress hormones have acute adverse effects on glycaemic control. The aim of this study was to assess the effect of chronic psychological and physical stress on the expression of insulin receptor (INSR) and glucose transporter-4 (GLUT4) in male Sprague–Dawley r...

Breast cancer is the most frequent carcinoma in women and its prevalence could be reduced by early detection which can improve the chances of successful treatment and recovery. Post transcriptional genetic modifiers known as microRNAs (miRNAs) are widely believed to play an essential role in many malignancies, acting as either tumor suppressors or oncogenes. Many recent studies on breast cancer have analyzed various miRNAs that may influence breast cancer progression and devel...

We examined the effect of dietary niacin supplementation on fat mass, glucose control, insulin sensitivity, lipid profile, and adiponectin level in diet-induced obese rats. Twenty-one male Sprague-Dawley rats (n=21) were initially divided into two (2) groups of seven and fourteen rats; the group of 14 rats was fed with a high-fat-diet (HFD) and the other group of 7 rats consumed the control diet. Eight weeks after the diet regimen started, half of the rats from the HFD group w...

Recently there has been reports that the administration of hormonal contraceptives alter the metabolic processes and micronutrients levels. Meanwhile some of these micronutrients are cofactors and or coenzymes of enzymes and are involved in important metabolic pathways. We compared the influence of three contraceptive methods (oral contraceptive, injectables and implants) on serum levels of Iron, ferritin, copper, ceruloplasmin and Vitamin E, using standard methods. Blood samp...