Searchable abstracts of presentations at key conferences in endocrinology

ea0032p555 | Endocrine tumours and neoplasia | ECE2013

Type 1 gastric endocrine tumors as an autoimmune disease, with emphasis to lymphocytic thyroiditis

Santos Ana Paula , Couto Joana , Martins Raquel , Silva Rui

Introduction: Type 1 gastric endocrine tumors (T1-GET) incidence is increasing world while mainly due to widespread use of upper endoscopy. Autoimmune disease (AID) is the hallmark of T1-GET, pernicious anemia is often found at presentation. Association with lymphocytic thyroiditis (LT) has been described.Aims: Retrospective evaluation of GET data from patients (pts) followed at IPO-Porto, including the presence of other AID with emphasis to LT.<p cl...

ea0040p15 | (1) | ESEBEC2016

Post-pancreatectomy persistent adult nesidioblastosis: follow-up of 24 years

Almeida Raquel , Santos Ana Paula , Gomes Jose Teixeira , Lima Bastos , Bacelar Conceicao

Introduction: Adult nesidioblastosis is a rare entity that has motivated the publication of several case reports, but long-term outcomes are rarely described. Distal or sub-total pancreatectomy is indicated in cases of severe symptoms or lack of response to medical treatment. We report the case of a patient with persistent nesidioblastosis after pancreatectomy keeping under medical treatment for 24 years.Clinical case: Woman currently with 81-years old, ...

ea0032p202 | Cardiovascular Endocrinology &amp; Lipid Metabolism | ECE2013

Dyslipidemia associated with m-TOR inhibitors treatment

Couto Joana , Martins Raquel , Carneiro Filipa , Santos Ana Paula , Torres Isabel

Introduction: Therapeutic approach of patients (pts) with metastatic renal cell carcinoma (mRCC) may include the use of biological agents such as m-TOR inhibitors: temsirolimus (TM) and everolimus (EV). Its use is associated with metabolic dysfunction, especially with everolimus: hyperglycemia (37% TM treated pts vs 72% EV treated pts), hypercholesterolemia (25% TM treated pts vs 81% EV treated pts) and hypertriglyceridemia (30% TM treated pts vs 73% EV treated pts). Discontin...

ea0032p568 | Endocrine tumours and neoplasia | ECE2013

Therapy with 177Lu marked somatostatin analogues in a case of pancreatic metastatic neuroendocrine tumor

Belo Sandra , Lucena Ines , Santos Ana Paula , Afonso Luis Pedro , Sanches Cristina , Duarte Hugo

Introduction: Conventional systemic therapies have limited role in metastasized neuroendocrine tumors (NET). Therefore an increasing role is attributed to 177Lu labeled somatostatin analogues (SA).Case: Man, 52 years, referred because of NET, diagnosed following liver biopsy for hepatic nodules (liver tissue infiltrated by NET, compatible with metastases). Endoscopic ultrasound revealed pancreatic nodular formation, 40×24 mm; 99</sup...

ea0056ep5 | Adrenal and Neuroendocrine Tumours | ECE2018

Isolated pheochromocytoma associated with mutation in the SDHAF2 (SDH5) gene: rare and challenging clinical case

Oliveira Sofia Castro , Santos Ana Paula , Goncalves Ligia , Ferreira Goncalo , Lima Jorge , Teixeira Manuel , Torres Isabel

Introduction: Pheochromocytomas/paragangliomas are rare neuroendocrine tumors. Although mostly sporadic, about 1/3 of the cases correspond to inherited autosomal dominant syndromes, often associated with germline mutations of the SDHD, SDHC and SDHB genes. The association with the SDHAF2(SDH5) gene has been recently discovered, with only few cases published worldwide, and it presents as a paraganglioma of the head and neck, without previous known description of other locations...

ea0070ep447 | Thyroid | ECE2020

Mixed medullary-papillary thyroid carcinoma with mixed lymph node metastases

Guerreiro Vanessa , Costa Cláudia , Oliveira Joana , Santos Ana Paula , Farinha Mónica , Freitas Paula , Torres Isabel

Introduction: Medullary thyroid carcinoma (MTC) and papillary thyroid carcinoma (PTC) are two distinct neoplasms originating from follicular and parafolicular-C cells, respectively. These pathologies have always been considered different from each other in terms of their incidence, their cell origin and their histopathological features. Concurrent occurrence of MTC and PTC in the same patient is an unusual event and its occurrence as true mixed medullary-follicular-derived car...

ea0032p1089 | Thyroid cancer | ECE2013

68Ga-DOTA-NOC PET/CT role in the follow-up of patients with medullary thyroid carcinoma

Couto Joana , Martins Raquel , Lucena Ines , Menezes Joana , Santos Ana Paula , Rodrigues Elisabete , Duarte Hugo , Torres Isabel

Introduction: About 50% of patients with medullary thyroid carcinoma (MTC) have persistent or recurrent disease after surgery.For a calcitonin (ct) value greater than 150 pg/ml, it is suggested by international guidelines performing additional imaging exams (AIE) for evaluating the presence of distant metastasis. It is often difficult to assess the presence of nodal disease and secondary liver lesions (often miliary) by ‘morphological’ imaging ...

ea0022p827 | Thyroid | ECE2010

Cito-histologycal correlations in nodular thyroid pathology

Couto Joana , Lobo Claudia , Barbosa Ana Paula , Martins Raquel , Santos Ana Paula , Monteiro Paula , Amaro Teresina , Torres Isabel

Introduction: Fine needle biopsy (FNB) is a very important diagnostic tool in the assessment of thyroid nodules and plays a prominent role in therapeutic approach. It has a sensitivity around 83 to 85% and a specificity around 80 to 92%.Aims: To correlate cytological (FNB) and final histopathological data in patients with nodular thyroid pathology.Methods: A retrospective study of patients who underwent surgical procedure from Janu...

ea0081p535 | Adrenal and Cardiovascular Endocrinology | ECE2022

Minimally invasive treatment of conn’s adenoma: real world cases in tertiary oncology center

Costa Claudia , Franco Sara , Santos Ana Paula , Goncalves Belarmino , Gil-Santos Sara , Oliveira Joana , Souteiro Pedro , Jose Sousa Maria , Torres Isabel

Introduction: Primary aldosteronism (PA) is a rare but underestimated cause of hypertension. PA has been associated with increased risk of malignancy through mechanisms involving up-regulation of the renin angiotensin system (RAS) promoting an enzymatic cascade influencing carcinogenesis. Recently, Microwave Ablation (MWA) has been established as an effective and safe minimal invasive treatment for Conn’s Disease.Aim: The authors present four clinic...

ea0049ep100 | Adrenal medulla | ECE2017

Lung adenocarcinoma in a 34-year-old female SDHB asynptomatic mutation carrier – case report

Matos Maria Joao , Costa Claudia , Santos Ana Paula , Teixeira Manuel , Franco Carlos , Bento Joao , Azevedo Isabel , Dias Susana , Sampaio Ines Lucena , Cunha Ana Luisa , Torres Isabel

Introduction: Patients with germline mutations in one of the succinate dehydrogenase (SDH) genes are at substantially increased risk of developing paragangliomas (PGL) and pheochromocytomas (PCC). Mutations in SDHB are the most commonly found gene mutations in PC/PGL and are associated with younger ages at presentation, higher rates of metastases and poorer prognosis. Although familial PGL syndromes were initially thought to predispose only for PCC and PGL, other tumor types s...