Endocrine Abstracts

Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is a relatively recent and rare disease, frequently misdiagnosed. It is characterized as a generalized proliferation of pulmonary neuroendocrine cells and is recognized as a precursor lesion for pulmonary neuroendocrine tumors, although the risk of progression to malignancy is considered low. Here we report a patient with ectopic ACTH-dependent Cushing’s syndrome due to metastatic lung carcinoid tumors...

Introduction: Graves’ orbitopathy is usually associated with Graves’ Disease, which is typically characterized by hyperthyroidism and goiter. However, in rare situations, Graves’ disease can also present with hypothyroidism and orbitopathy.Case report: Male, 38 years old, followed by his ophthalmologist for thyroid orbitopathy (exophthalmos right>left and conjunctival hyperaemia since 1 year ago) associated with asthenia, tiredness and...

Introduction: Familial chylomicronemia syndrome (FCS) is a rare inherited disorder of lipoprotein metabolism leading to severe hypertriglyceridemia and increased risk for acute pancreatitis. Mutations in the lipoprotein lipase (LPL) gene account for the majority of cases of monogenic chylomicronemia.Methods: We report the cases of two white males with a novel homozygous mutation in position 332 of the LPL gene.Res...

Introduction: Adrenal myelolipomas are rare benign tumors. There has been an association of adrenal myelolipomas with other pathologies with hormonal hypersecretion, such as hypersecretion of adrenocortical hormone (ACTH) in Cushing’s Disease and Congenital adrenal hyperplasia. We report a case of acromegaly with co-existent large adrenal myelolipoma.Case Report: A 48-year-old caucasian male was referred to our Endocrinology consultation for an adre...

Introduction: Intra-thyroid metastases are infrequent, comprising only 1-3% of all thyroid malignancies. Renal cell carcinoma, particularly of the clear cell type (CCRC), stands out as the predominant kidney malignancy and the most common primary source of intra-thyroid metastases, often manifesting several years post-diagnosis. This report highlights two cases of CCRC metastasis to the thyroid, both featuring deceptive cytological findings.Case 1: A 60-...

Introduction: The anatomical and physiological changes induced by bariatric surgery (BS) can significantly impact the absorption and pharmacokinetics of orally administered medication. In particular, levothyroxine (LT4) dosage, given its dependence on patient’s weight and gastric pH for optimal absorption, is expected to change following BS. However, the literature is not unanimous and there is a void of longer-term studies. We aimed to compare LT4 dosage 4 years followin...

Introduction: Although lifestyle measures and medical therapy are the cornerstone of type 2 diabetes (T2DM) management, achieving optimal glycemic control in T2DM patients with obesity remains challenging. There is strong and consistent evidence that bariatric surgery (BS) is an effective strategy to improve glycemia in diabetic patients and often leads to remission of T2DM in patients with obesity. The majority of the published literature supporting T2DM remission after BS ha...

Introduction: Diabetic foot infection imposes a significant burden and is a major cause of non-traumatic limb amputation. Antibiotic therapy plays a crucial role in the management these patients. In our institution, empirical antibiotic therapy is tailored to the presence of risk factors for multidrug-resistant microorganisms. For patients without risk factors, empirical intravenous amoxicillin-clavulanate at a dose 2.2 g every 8h is used. For patients with risk factors such a...

Background: Bariatric surgery leads to weight loss and to cardiometabolic risk improvement. Although prediabetes remission after bariatric surgery is biologically plausible, data on this topic is scarce.Aim: We aimed to access pre-diabetes remission rate and clinical predictors of remission in a 4 year follow up period.Methods: Observational longitudinal study including patients with morbid obesity and prediabetes submitted to bari...