Searchable abstracts of presentations at key conferences in endocrinology

ea0016p421 | Neuroendocrinology | ECE2008

Glucose-dependent insulinotropic polypeptide receptor (GIPR) in human pituitary adenomas

Occhi Gianluca , Losa Marco , Albiger Nora , Scanarini Massimo , Del Verme Jacopo , Mantero Franco , Scaroni Carla

Glucose-dependent insulinotropic polypeptide (GIP) receptor is a member of the G protein-coupled receptors family. According to its incretin properties, GIPR is expressed in tissues such as pancreas, stomach and adipose tissue. However GIPR expression pattern appears to be broader, as it was detected in other tissues such as heart, lung and the central nervous system, thus suggesting either novel ligands for GIPR or novel actions for GIP. Moreover, in some patients with food-d...

ea0022p386 | Endocrine tumours &amp; neoplasia (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Everolimus reduces human ACTH-secreting pituitary adenoma in vitro cell viability

Zatelli Maria Chiara , Minoia Mariella , Filieri Carlo , Tagliati Federico , Mole Daniela , Scanarini Massimo , Ambrosio Maria Rosaria , degli Uberti Ettore

Everolimus (RAD001), an immunosuppressant drug, has antineoplastic activity in human neoplasia, including endocrine tumors, due to its ability to inhibit the AKT down-stream signaling pathway. It has been demonstrated that AKT is overexpressed and up-regulated in pituitary tumor, including ACTH-producing pituitary tumors, that are still orphan of an effective medical therapy. We therefore investigated the effects of RAD001 on cell viability, apoptosis and mTOR phosphorilation ...

ea0016s14.2 | Basic highlights | ECE2008

Dopamine receptor 2 activation reduces cells viability in non-functioning pituitary adenomas by inhibiting vascular endothelial growth factor secretion

Zatelli Maria Chiara , Tagliati Federico , Luchin Andrea , Ambrosio Maria Rosaria , Cimino Vincenzo , Bondanelli Marta , Scanarini Massimo , Maira Giulio , De Marinis Laura , degli Uberti Ettore

Dopamine (DA) therapy of non-functioning pituitary adenomas (NFA) can result in tumor stabilization and shrinkage. However, this effect is not always apparent and the mechanism of action is still unknown. Previous evidence showed that DA inhibits pituitary Vascular Endothelial Growth Factor expression (VEGF), that, in turn, is related to pituitary tumor growth. Our study aimed at clarifying whether VEGF secretion modulation might mediate the effects of DA agonists and chimeric...

ea0014oc3.1 | Endocrine tumors &amp; neoplasia | ECE2007

Multiple somatostatin receptor subtypes activation reduces cell viability in non-functioning pituitary adenomas by inhibiting Vascular Endothelial Growth Factor secretion

Zatelli Maria Chiara , Piccin Daniela , Tagliati Federico , Ambrosio Maria Rosaria , Bianchi Antonio , Bondanelli Marta , Schmid Herbert A , Scanarini Massimo , Marinis Laura De , Maira Giulio , Uberti Ettore C degli

Somatostatin (SRIF) analogs have been employed in medical therapy of non-functioning pituitary adenomas (NFA), with contrasting results. Previous evidence showed that SRIF can exert its antiproliferative effects by reducing Vascular Endothelial Growth Factor (VEGF) secretion and action, and that VEGF expression may be related to pituitary tumor growth. The aim of our study was to clarify the possible effects of a multireceptor SRIF ligand on VEGF secretion and cell proliferati...

ea0014p567 | (1) | ECE2007

Medial cerebral artery occlusion 25 years after cranial radiation therapy in acromegaly

Maffei Pietro , Martini Chiara , Barban Martina , Carli Marta , Manara Renzo , Scanarini Massimo , Mazzarotto Renzo , Meneghetti Giorgio , Menegazzo Carla , Mioni Roberto , De Carlo Eugenio , Vettor Roberto , Sicolo Nicola

Introduction: Epidemiological studies indicate that patients with acromegaly have increased mortality rates for cardiovascular and cerebrovascular disease (CVD). Potentials risk factors for increased CVD include hypopituitarism and cranial radiation therapy (CRT).Case Report: A 43-year-old acromegalic woman was admitted because of worsening headache, left lower facial numbness and left arm weakness. Two weeks later she developed a central palsy of the le...