Searchable abstracts of presentations at key conferences in endocrinology

ea0041ep957 | Steroid metabolism + action | ECE2016

Similarity and differences of maximal and sub-maximal endurance exercise in increase the serum testosterone and DHT concentrations in healthy males

Sgro Paolo , Sansone Massimiliano , Romanelli Francesco , Lenzi Andrea , Bianchini Serena , Luigi Luigi Di

Introduction: Physical exercise exerts several effects on endocrinological homeostasis and, in particular, sprint exercise elicits the largest testosterone response per unit of work, while in response to prolonged endurance exercise testosterone levels will typically decline. In contrast to a large amount of paper about the modification of testosterone during physical exercise few study evaluated how DHT was influenced by a single bout of aerobic exercise.<p class="abstext...

ea0084ps1-01-04 | COVID & Thyroid Disease | ETA2022

Subacute thyroiditis: The severity depends on the causative agent and the treatment requires a lower glucocorticoid dose than that recommended by the guidelines

Viola Nicola , Brancatella Alessandro , Sgro Daniele , Casula Mauro , Santini Ferruccio , Latrofa Francesco

Subacute thyroiditis (SAT) is an inflammation of the thyroid gland characterized by varying degrees of severity regarding thyrotoxicosis, inflammation and the incidence of hypothyroidism. The present study aims to identify whether the severity of SAT depends on the causative agent involved and to identify what is the optimal therapy. To this purpose we retrospectively evaluated 402 patients referred to of the University Hospital of Pisa because of to a SAT from January 2011 to...

ea0081p126 | Endocrine-Related Cancer | ECE2022

Ultrasound and cytological features of thyroid nodules with aggressive behavior: from histology to clinic

Sgro Daniele , Greco Giuseppe , Brancatella Alessandro , Viola Nicola , Casula Mauro , Torregrossa Liborio , Rago Teresa , Santini Ferruccio , Latrofa Francesco

Fine-Needle Aspiration Biopsy (FNAB) is the recommended diagnostic tool for differentiating malignant from benign thyroid nodules and provides indication for surgical decisions. According to the Italian system, thyroid nodules are classified as TIR 1/1C, TIR 2, TIR 3A, TIR3B, TIR4 or TIR5, which correspond to Thy I, Thy II, Thy III, Thy IV, Thy V and Thy VI categories of the Bethesda system. TIR 3 identifies the indeterminate nodules. Surgery is usually recommended for TIR 3B,...

ea0081p464 | Thyroid | ECE2022

Steroid treatment in the management of destructive thyrotoxicosis induced by PD1 blockade

Brancatella Alessandro , Pierotti Laura , Lupi Isabella , Montanelli Lucia , Viola Nicola , Sgro Daniele , Sardella Chiara , Antonangeli Lucia , Brogioni Sandra , Cremolini Chiara , Marcocci Claudio , Santini Ferruccio , Latrofa Francesco

Objective: Destructive thyroiditis is the most common endocrine immune related adverse event (iRAEs) in patients treated with anti-PD1/PD-L1 agents. Given its self-limited course, current guidelines recommend no treatment for this iRAE. Nevertheless in patients with enlarged thyroid volume and a poor performance status, thyrotoxicosis may be particularly severe and harmful. Aim of the study is to evaluate if steroid treatment might be useful in improving thyrotoxicosis in subj...

ea0070aep332 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Immune checkpoint inhibitors (ICIs) and ‘Fulminant Diabetes’: Two emblematic cases

Sgro’ Daniele , Giannarelli Rosa , Aragona Michele , Viola Nicola , Cosentino Giada , Brancatella Alessandro , Latrofa Francesco , Del Prato Stefano , Santini Ferruccio , Marcocci Claudio , Lupi Isabella

Context: Programmed cell death protein 1/programmed cell death protein ligand 1 (PD-1/PD-L1) are key regulators in T-cell activation and tolerance. Nivolumab (PD-1 inhibitor) and Atezolizumab (PD-L1 inhibitor) are monoclonal antibodies approved for the treatment of several types of advanced cancers. Immune checkpoint inhibition caused by these drugs can result in immune-related adverse events (irAEs) New-onset diabetes mellitus has been reported in fewer than 1% of patients an...

ea0016p11 | Adrenal | ECE2008

Phosphodiesterase inhibitors and adrenal response to exercise-related stress

Sgro Paolo , Gallotta Maria Chiara , Emerenziani Gian Pietro , Fierro Valentina , Guidetti Laura , Baldari Carlo , Romanelli Francesco , Lenzi Andrea , Di Luigi Luigi

Worldwide numerous active individuals take phosphodiesterase type 5 inhibitors (PDE-5i), furthermore, to our knowledge, the effects of these drugs on hormone secretion has not been adequately investigated. In particular, considering that a) PDE-5i influence NO bioavailability, b) NO is one of the mediators of the hypothalamus┬ľpituitary┬ľadrenal (HPA) axis response to stress, and, c) physical exercise-related stress activate HPA axis, we investigated whether PDE-5i inf...