Searchable abstracts of presentations at key conferences in endocrinology

ea0090ep176 | Calcium and Bone | ECE2023

Hypophosphatasia: recurrent fractures and a suppressed alkaline phosphatase level - can we make the connection?

Shah Najeeb , Thow Jonathan

Case: A 66-year-old female was referred to the Endocrinology clinic for suspected osteoporosis after a right femoral shaft fracture. As the site was atypical and the injury was low energy, a pathological fracture was suspected. There was a history of recurrent fractures sustained after the age of 30 years and were either spontaneous or from low-energy impacts (Table 1). Growing up, she was told that “there was something wrong with her bones” and required regular phys...

ea0090ep601 | Endocrine-related Cancer | ECE2023

An Oestrogen-secreting neuroendocrine tumour in the lung

Shah Najeeb , Thow Jonathan

Case: A 59-year-old female with a past medical history of surgically treated primary hyperparathyroidism (PHPT) and breast cancer presented with irregular periods, post-menstrual bleeding, hot flushes, fatigue, and left loin pain. Furthermore, she reported weight gain of approximately 8 lb over 6 months and easy bruising in the absence of antiplatelet and anticoagulant therapy. There were no central, respiratory, or gastrointestinal symptoms. She was normotensive, and the clin...

ea00100wa5.3 | Workshop A: Disorders of the hypothalamus and pituitary (I) | SFEEU2024

Cranial diabetes insipidus (CDI) secondary to langerhans cell histiocytosis (LCH)

Shah Najeeb , Mongolu Shiva

A 46 years old male with a background history of hypertension and asthma for which he was taking irbesartan and clenil inhaler respectively, was referred to the Endocrine service with a 3 weeks’ history of polyuria, polydipsia, nocturia and occasional headaches. On initial screening, diabetes mellitus and hypercalcemia were excluded. Initial biochemistry showed a sodium level was 144 mmol/l (135-144) with a serum osmolality of 300 mOsm/kg (275-295). A diagnosis of Diabete...

ea0086p316 | Bone and Calcium | SFEBES2022

Severe hypercalcaemia with short QT interval due to vitamin D intoxication secondary to unsupervised exogenous vitamin D administration

Taqi Muhammad , Shah Najeeb , Karim Rehmat

Case: A 34-years-old male, construction worker, referred by GP with the history of vomiting, fatigue and near-collapse. Apart from alcohol excess, his past medical history was unremarkable. He did not have any personal or family history of any endocrinopathy, and was not taking any medication. Initial blood result were as below. ECG showed short QTc interval of 354 ms. His presentation was initially thought to be vomiting due to alcohol excess leading to dehydration and hyperc...

ea0056p55 | Adrenal cortex (to include Cushing's) | ECE2018

Abnormal salivary cortisol result in patient with low probability of Cushing disease

Ahmed Ali , Shah Najeeb , Mohammed Kamrudeen

We presenting a case of 26 old lady who is known to have Denys-Drash syndrome, epilepsy and bronchial asthma who presented with history of recent significant weight gain, extensive abdominal bruising and significant muscle weakness which she described literally as not able to use her upper limbs to move to help shuffle her bottom in the floor, a manoeuvre that she was able to do before. Patient is on Carbamazepine, sodium valporate, levetiracetam , salbutamol and Pulmicort inh...

ea0077p23 | Adrenal and Cardiovascular | SFEBES2021

Feminizing adrenal tumours (FAT): Rare tumours of the adrenal gland

Mishra Ashish , Deshmukh Harshal , Shah Najeeb , Sathyapalan Thozhukat , Mongolu Shiva

Functioning adrenal masses are often a diagnostic challenge and can present with unusual symptoms. We describe a case of a 37-year-old male with a background of ulcerative colitis, who presented with gynecomastia in the breast clinic. His serumbiochemistry showed persistently elevated Oestradiol and prolactin, with low testosterone and FSH. On physical examination, he had marked breast tenderness, bilateral gynecomastia and no signs of steroid excess. He reported a decline in ...

ea0077p109 | Reproductive Endocrinology | SFEBES2021

The relationship between polycystic ovarian syndrome and fractures: A Mendelian randomization study using the UK Biobank

Shah Najeeb , Deshmukh Harshal , Aye Mo , Sathyapalan Thozhukat

Background: Polycystic ovary syndrome (PCOS) is believed to be a primeval condition with the earliest hints of its existence found in ancient Egyptian literature. Despite its negative impact on fertility, it has emerged as the most common endocrine disorder in women of reproductive age, creating what is called the PCOS paradox. We hypothesized that this phenomenon can be explained by testosterone-mediated high bone mineral density (BMD) in women with PCOS, providing a survival...

ea0050ep041 | Clinical Biochemistry | SFEBES2017

Sertraline-induced non-hyperinsulinemic hypoglycaemia in a non-diabetic patient : A case report

Karim Rehmat , Shah Najeeb , Jadoon Nauman , Mohammed Kamrudeen

Case: A 44-year-old patient presented with symptoms of sweating, shaking and hunger, which were all eased by eating. Her symptoms were suggestive of hypoglycaemia, experienced predominantly 2-3 hours after meals. Hypoglycaemia was confirmed during these episodes. She had normal liver and renal function. There was no history of Diabetes Mellitus.Her symptoms improved slightly with measures of adjusting her diet but did not sett...

ea0050ep041 | Clinical Biochemistry | SFEBES2017

Sertraline-induced non-hyperinsulinemic hypoglycaemia in a non-diabetic patient : A case report

Karim Rehmat , Shah Najeeb , Jadoon Nauman , Mohammed Kamrudeen

Case: A 44-year-old patient presented with symptoms of sweating, shaking and hunger, which were all eased by eating. Her symptoms were suggestive of hypoglycaemia, experienced predominantly 2-3 hours after meals. Hypoglycaemia was confirmed during these episodes. She had normal liver and renal function. There was no history of Diabetes Mellitus.Her symptoms improved slightly with measures of adjusting her diet but did not sett...

ea0090p162 | Pituitary and Neuroendocrinology | ECE2023

An unusual sellar dermoid cyst

Akbar Shahzad , Taqi Muhammad , Shah Najeeb , Mongolu Shiva , Aye Mo

Introduction: Dermoid cysts are rare (0.5% of intracranial tumours). They are best considered a spectrum: from epidermoid cysts containing desquamated squamous epithelium to teratomas containing all three embryonic tissues. Sellar dermoid cysts are even rarer [Orpha.net ID: ORPHA:91351]. Case: A 47-year old white British male was referred following incidental discovery of bitemporal field defect on routine eye test. He was otherwise completely asymptomat...