Endocrine Abstracts

Background: Medullary thyroid carcinoma (MTC) is a rare thyroid neoplasm with a high degree of malignancy derived from the parafollicular calcitonin-secreting cells. This carcinoma may occur sporadically in about 80% of cases or it may be part of the autosomal dominant multiple endocrine neoplasia (MEN) type 2. While the 10-year survival rate is around 40–75%, for metastatic disease, it’s just below 20%.Case presentation: We report the case of ...

Trabecular bone score (TBS) evaluates bone microarchitecture by measuring the grey-level variations from lumbar spine dual-energy X-ray absorbtiometry (DXA) images. Bone mineral density (BMD) in various endocrinopathies might not be sufficient in assessing bone fragility, especially in patients with acromegaly (ACM) but also in thyrotoxicosis. The aim of our study was to evaluate bone quality and quantity by BMD and TBS in patients with acromegaly and thyrotoxicosis.<p cla...

Background: Osteoporosis is a chronic metabolic bone disease, highly prevalent in the elderly population, especially in postmenopausal women. Denosumab is a potent anti-resorptive drug, which can be used as an initial therapy or as an alternative therapy in the treatment of osteoporosis.Objective: We aimed to analyze the characteristics of patients, the evolution of bone mass density (BMD) and trabecular bone score (TBS) and the factors associated with f...

Introduction: Acromegalic bone disease is characterized by an increased prevalence of fragility vertebral fractures (VFs). However, an effective, non-invasive and cost-efficient imaging technique that can diagnose early bone alterations in this category of patients is yet to found. The use of bone mineral density (BMD) is not as useful as in other causes of osteoporosis as excess GH leads to specific microarchitectural alteration of trabecular bone, which don’t translate ...

Background: Hyperthyroidism is widely known to be an important cause of secondary osteoporosis through the accelerated rate of bone turnover, while primary hyperparathyroidism is typically associated with loss of cortical bone and less so of trabecular bone, as seen on dual-energy x-ray absorptiometry (DXA). The evaluation of bone quality in these categories is not fully understood and needs further research. The aim of this study was to compare the bone quantity and quality, ...

Background: Acromegaly is characterized by increased prevalence of fragility vertebral fractures. Nonetheless, there are no clear recommendations for prevention of acromegalic osteopathy. Both bone mineral density (BMD) and trabecular bone score (TBS) lack clear evidence as prognostic factors for vertebral fractures (VF).Material and Methods: We performed an observational study on 31 acromegalic patients recruited prospectively. They were tested for alka...