Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep169 | Endocrine tumours and neoplasia | ECE2017

Respiratory symtoms lead to a diagnosis of pheochromocytoma: An unusual presentation

Teles Luis , Neves Joao Sergio , Souteiro Pedro , Oliveira Sofia Castro , Neves Celestino , Freitas Paula , Carvalho Davide

Introduction: Pheochromocytoma is one of the major secondary causes of hypertension. The classic triad of pheochromocytoma symptoms of headache, sweating and tachycardia is not present in a high percentage of patients and is sometimes diagnosed as incidentaloma or atypical presentations.Case report: The authors present a 56-year-old man, with no known diseases, referred to Endocrinology evaluation by incidentaloma of the right adrenal gland, from the Pne...

ea0049ep493 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Bronze diabetes – a rare secondary cause of diabetes

Souteiro Pedro , Neves Joao Sergio , Oliveira Sofia Castro , Belo Sandra , Neves Celestino , Freitas Paula , Carvalho Davide

Introduction: Secondary causes of diabetes refer to a category in which diabetes is associated with other diseases. They are thought to constitute less than 2% of the total cases of diabetes.Case report: A 56 year-old caucasian man, with no relevant medical history, presented to the Emergency Department with fatigue, polyuria, polydipsia, polyphagia and involuntary weight loss (6 kg in two weeks). He was hemodynamically stable and exhibited a glycaemia o...

ea0049ep1081 | Pituitary - Clinical | ECE2017

Hypopituitarism and central diabetes insipidus in an HIV patient – a late complication of cerebral toxoplasmosis and/or antiretrovirals?

Oliveira Sofia Castro , Souteiro Pedro , Neves Joao Sergio , Nogueira Claudia , Neves Celestino , Freitas Paula , Carvalho Davide

Introduction: The endocrine system is often affected in the course of HIV infection. However, hypopituitarism and diabetes insipidus are uncommon disorders in these patients and have been related to drugs, infections of the central nervous system and neoplastic infiltration, in extremely rare cases.Case report: We present a case of a 42-year-old man with HIV infection known since 2005, but undergoing antiretroviral therapy only since 2010 (emtricitabine/...

ea0041ep52 | Adrenal cortex (to include Cushing's) | ECE2016

Adrenal leiomyoma: a rare cause of adrenal incidentaloma

Manuel Costa Maria , Belo Sandra , Souteiro Pedro , Magalhaes Joao , Carvalho Davide

Introduction: Leiomyomas are benign tumors originating from the smooth muscle cells. They occur more frequently in the uterus and in the gastrointestinal system. Adrenal leiomyomas are rare tumors arising from the smooth muscle of the adrenal vein and its tributaries.Case report: Man, 72-years-old, referred to Endocrinology in the context of an adrenal incidentaloma (20 mm maximum diametre) detected in abdominal-pelvic CT performed for the study of splen...

ea0041ep312 | Clinical case reports - Pituitary/Adrenal | ECE2016

Insipid diabetes and acute myeloid leukemia: genotypic/phenotypic correlation?

Manuel Costa Maria , Belo Sandra , Souteiro Pedro , Luis Castedo Jose , Carvalho Davide

Introduction: Central diabetes insipidus (CDI) is a rare complication of acute myeloid leukemia (AML) occurring in less than 0.6% of patients. It is associated with genetic changes in chromosomes 3 and 7. CDI may precede; occur simultaneously or after the diagnosis of AML.Case report: 51-year-old man, with no relevant past medical history, began complaining with polyuria, polydipsia, weakness and weight loss in March 2015.The patient was evaluated in the...

ea0041ep490 | Diabetes complications | ECE2016

Mauriac syndrome – a rare type 1 diabetes mellitus complication and an opportunity for intervention

Souteiro Pedro , Belo Sandra , Costa Maria Manuel , Carneiro Fatima , Carvalho Davide

Introduction: Mauriac Syndrome is characterized by the presence of hepatomegaly, growth retardation, delayed puberty and cushingoid features. This entity is traditionally diagnosed during the work-up of hepatic enzymes alterations in children/young adults with type 1 diabetes mellitus (T1DM) with poor glycaemic control. However, the impact of metabolic control in the normalization of hepatic analytic profile is not clarified.Methods and design: Retrospec...

ea0041ep1035 | Thyroid (non-cancer) | ECE2016

Propylthiouracil induced ANCA-associated vasculitis

Souteiro Pedro , Freitas Joana , Amaral Susana , Belo Sandra , Nogueira Claudia , Pereira Rodrigues , Meirinho Ivone

Introduction: Propylthiouracil is a drug used in the treatment of hyperthyroidism and autoimmunity phenomena have been described as a side effect of its use. Despite anti-neutrophil cytoplasmic antibodies (anca) positivity is frequent in patients treated with propylthiouracil, the occurrence of clinically evident vasculitis is rare.Case report: A 65-year-old woman, diagnosed with hyperthyroidism 2 years ago and treated with propylthiouracil (50+...

ea0056p64 | Adrenal cortex (to include Cushing's) | ECE2018

Bilateral macronodular adrenal hyperplasia with autonomous cortisol secretion

Nogueira Claudia , Cunha Filipe , Souteiro Pedro , Oliveira Sofia Castro , Mesquita Joana

Introduction: Bilateral macronodular adrenal hyperplasia is a rare cause of Cushing’s syndrome (CS) characterized by multiple adrenal nodules >1 cm. It can be diagnosed in patients with overt CS but is more often diagnosed incidentally, especially in the 5th or 6th decades of life.Clinical case: 61-year-old woman with type 2 diabetes, arterial hypertension and dyslipidemia treated with metformin+sitagliptin 1000/50 mg bid, valsartan+hydrochlorot...

ea0049ep194 | Endocrine tumours and neoplasia | ECE2017

Acinic cell adenocarcinoma of the parotid gland associated with paraneoplastic Cushing’s syndrome – a rare clinical case

Castro Oliveira Sofia , Sergio Neves Joao , Souteiro Pedro , Belo Sandra , Isabel Oliveira Ana , Neves Celestino , Freitas Paula , Carvalho Davide

Introduction: Primary acinic cell carcinoma (ACC) is an uncommon salivary gland (SG) tumor, making up 1–3% of all SG neoplasms, more frequent in women, at 40–60 year old. The cause is still unknown and the only well-established risk factor is ionizing radiation. ACC metastasize in 10–15% of the cases, 35% tends to recur and the rate of disease-associated death is about 16%. Surgical resection is the mainstay treatment, but radiation therapy may be used in some c...

ea0049ep195 | Endocrine tumours and neoplasia | ECE2017

Malignant pheochromocytoma – a challenging diagnosis with nonconsensual management

Castro Oliveira Sofia , Sergio Neves Joao , Souteiro Pedro , Lau Eva , Isabel Oliveira Ana , Neves Celestino , Freitas Paula , Carvalho Davide

Introduction: Pheochromocytomas and extra-adrenal paragangliomas are rare neuroendocrine tumors, with a peak incidence between the 3rd–5th decades of life and about 10% are malignant. Although they have the same radiographic and histologic characteristics of their benign counterpart, malignant pheochromocytomas are diagnosed by the presence of local invasion or metastatic tumor in the non-chromaffin tissues, and offer a poorer prognosis. Treatment is typically extirpative...