Endocrine Abstracts

Case history: A 34 year old Chinese male was referred by GP as routine blood test which was done as part of investigation for ongoing hair loss that revealed hypocalcaemia. Patient was asymptomatic with no tingling sensation, numbness or anaesthesia. There was no history of carpopedal spasm, muscle pain or cramps. He does not give any history of symptoms suggestive of malabsorption. His PMH include Mild asthma and Eczema for which he was not on any regular medication. Social h...

Background: Bariatric surgery for severe obesity can lead to micronutrient/vitamin deficiencies.Aim: To study baseline and post-surgical prevalence of vitamin D deficiency in patients undergoing bariatric surgery.Setting: University teaching hospital in North-West England.Methods: We performed an observational cohort analysis of longitudinal data on vitamin D and related parameters in patients who underwent b...

Background: Subacute thyroiditis is a self-limited inflammatory thyroid disorder with a triphasic clinical course of thyrotoxicosis, hypothyroidism, and return to euthyroidism. Whilst glucocorticoid (GC) treatment is advocated for managing moderate-to-severe symptoms, the ideal initiating dose and titration regime is unclear. Traditionally, doses of up to 40 mg of prednisolone have been used. More recently, to minimize adverse effects, a 15 mg initiation dose of ...

Background: Bariatric surgery for severe obesity can lead to micronutrient/vitamin deficiencies.Aim: To study baseline and post-surgical prevalence of vitamin D deficiency in patients undergoing bariatric surgery.Setting: University teaching hospital in North-West England.Methods: We performed an observational cohort analysis of longitudinal data on vitamin D and related parameters in patients who underwent b...

Background: Subacute thyroiditis is a self-limited inflammatory thyroid disorder with a triphasic clinical course of thyrotoxicosis, hypothyroidism, and return to euthyroidism. Whilst glucocorticoid (GC) treatment is advocated for managing moderate-to-severe symptoms, the ideal initiating dose and titration regime is unclear. Traditionally, doses of up to 40 mg of prednisolone have been used. More recently, to minimize adverse effects, a 15 mg initiation dose of ...

Purpose: Obesity and/or bariatric surgery can be associated with micronutrient deficiencies. We studied whether there was a correlation between body mass index (BMI) and micronutrient levels pre- and post-bariatric surgery.Methods: We performed a retrospective cohort study of 745 patients who underwent bariatric surgery in a Northwest England teaching hospital. Patients were recommended standard postoperative supplements consistent with national guidelin...

Section 1: Case history: A 46-year-old woman was referred to the Endocrinology clinic for evaluation of persistently elevated parathyroid hormone levels despite correction of previous vitamin D deficiency. She had a history of calcific tendinitis of the left shoulder and iris pigment dispersion syndrome. Notably, her mother had undergone two parathyroid surgeries for primary hyperparathyroidism with removal of three parathyroid glands, revealing multiple parathyroid adenomas a...

Background: TSH receptor antibody (TRAb) measurement, with a sensitivity of >97% and specificity of 100%, is considered the gold standard investigation for diagnosing Graves’ disease (GD).Aim: To evaluate clinical diagnosis of GD or non- GD hyperthyroidism at a University Teaching Hospital compared to TRAb result.Methods: Electronic records of patients who had a TRAb measurement between December 2009 and October 2015 were ...

A man in his sixties, with no previous history of thyroid dysfunction (Table 1), was commenced on Amiodarone for atrial fibrillation at the age of 64 years. 24 months after starting on Amiodarone, the patient was found to have a low TSH with markedly elevated fT4 but normal free T3 (fT3). He was asymptomatic, there was no goitre, thyroperoxidase and TSH-receptor antibodies were negative. The thyroid dysfunction was managed by non-interventional observation with gradual resolut...

Case history: A 51-year old female presented to emergency with occipital headache for 5 days on a background of recurrent headaches for over a year. She had been diagnosed with Hashimoto’s disease at the age of 30 and given levothyroxine, which she discontinued 5 years ago due to aversion to take medications. She had noticed cold intolerance and low energy. At presentation her body mass index was 25.26 kg/m2 and the physical exam was unremarkable; specifically,...