Endocrine Abstracts

Background: Bariatric surgery is the most successful treatment for patients with severe and complex obesity.Aims: To assess clinical outcomes after bariatric surgery in a specialist centre.Setting: Specialist weight management service in a university teaching hospital.Methods: We performed an observational analysis of clinical outcomes for patients who underwent bariatric surgery during the period 31st</...

Background: Bariatric surgery for severe obesity can lead to micronutrient/vitamin deficiencies.Aim: To study baseline and post-surgical prevalence of vitamin D deficiency in patients undergoing bariatric surgery.Setting: University teaching hospital in North-West England.Methods: We performed an observational cohort analysis of longitudinal data on vitamin D and related parameters in patients who underwent b...

Background: Subacute thyroiditis is a self-limited inflammatory thyroid disorder with a triphasic clinical course of thyrotoxicosis, hypothyroidism, and return to euthyroidism. Whilst glucocorticoid (GC) treatment is advocated for managing moderate-to-severe symptoms, the ideal initiating dose and titration regime is unclear. Traditionally, doses of up to 40 mg of prednisolone have been used. More recently, to minimize adverse effects, a 15 mg initiation dose of ...

Background: Bariatric surgery for severe obesity can lead to micronutrient/vitamin deficiencies.Aim: To study baseline and post-surgical prevalence of vitamin D deficiency in patients undergoing bariatric surgery.Setting: University teaching hospital in North-West England.Methods: We performed an observational cohort analysis of longitudinal data on vitamin D and related parameters in patients who underwent b...

Background: Subacute thyroiditis is a self-limited inflammatory thyroid disorder with a triphasic clinical course of thyrotoxicosis, hypothyroidism, and return to euthyroidism. Whilst glucocorticoid (GC) treatment is advocated for managing moderate-to-severe symptoms, the ideal initiating dose and titration regime is unclear. Traditionally, doses of up to 40 mg of prednisolone have been used. More recently, to minimize adverse effects, a 15 mg initiation dose of ...

Purpose: Obesity and/or bariatric surgery can be associated with micronutrient deficiencies. We studied whether there was a correlation between body mass index (BMI) and micronutrient levels pre- and post-bariatric surgery.Methods: We performed a retrospective cohort study of 745 patients who underwent bariatric surgery in a Northwest England teaching hospital. Patients were recommended standard postoperative supplements consistent with national guidelin...

Section 1: Case history: A 46-year-old woman was referred to the Endocrinology clinic for evaluation of persistently elevated parathyroid hormone levels despite correction of previous vitamin D deficiency. She had a history of calcific tendinitis of the left shoulder and iris pigment dispersion syndrome. Notably, her mother had undergone two parathyroid surgeries for primary hyperparathyroidism with removal of three parathyroid glands, revealing multiple parathyroid adenomas a...

Background: TSH receptor antibody (TRAb) measurement, with a sensitivity of >97% and specificity of 100%, is considered the gold standard investigation for diagnosing Graves’ disease (GD).Aim: To evaluate clinical diagnosis of GD or non- GD hyperthyroidism at a University Teaching Hospital compared to TRAb result.Methods: Electronic records of patients who had a TRAb measurement between December 2009 and October 2015 were ...

A man in his sixties, with no previous history of thyroid dysfunction (Table 1), was commenced on Amiodarone for atrial fibrillation at the age of 64 years. 24 months after starting on Amiodarone, the patient was found to have a low TSH with markedly elevated fT4 but normal free T3 (fT3). He was asymptomatic, there was no goitre, thyroperoxidase and TSH-receptor antibodies were negative. The thyroid dysfunction was managed by non-interventional observation with gradual resolut...

Case presentation: A 34-year-old woman was diagnosed with hypertension from the age of 26 years. She had been investigated in Canada previously and discovered to have a small left adrenal nodule, satisfactory aldosterone and renin levels, but raised urinary free cortisol levels and non-suppressed cortisol levels on overnight 1 mg dexamethasone suppression test. Upon assessment in our service, the patient reported a history of easy bruising and insomnia. Her BMI was 28.1 kg/m&#...