Searchable abstracts of presentations at key conferences in endocrinology

ea0041ep314 | Clinical case reports - Pituitary/Adrenal | ECE2016

Early carbohydrate metabolism disorders in a patient with acromegaly and family history of pituitary adenomas

Matchekhina Lubov , Tarasova Tatiana , Pigarova Ekaterina

Introduction: Acromegaly is a chronic, debilitating disorder caused by excessive growth hormone (GH) production predominantly due to a benign pituitary adenoma. The overall annual incidence of acromegaly is approximately 3.3 cases/million, with a prevalence of 58–130 cases/million people. Early carbohydrate metabolism disorders (ECMDs) are frequently associated with acromegaly. ECMDs – defined as IFG, IGT or their combination – its prevalence in patients with ac...

ea0049ep913 | Neuroendocrinology | ECE2017

Clinical case description of family with hereditary pituitary adenoma

Tarasova Tatiana , Pigarova Ekaterina , Dzeranova Larisa , Tulpakov Anatoly , Dedov Ivan

Introduction: In recent years, more attention is driven to the cause of hereditary forms of pituitary adenomas. Although for most cases causal genes are not discovered yet, AIP mutations are the most prevalent.Materials and Methods: Case descriptions, high-parallel sequencing using a gene panel (MEN1, CDKN1B, PRKAR1A, GNAS, AIP, SDHA, SDHB, SDHS, SDHD, PRKCA, CDKN2C, CDKN2A, POU1F1, PTTG2).Case description: Index ...

ea0049ep914 | Neuroendocrinology | ECE2017

Molecular and genetic basis of the disease in families with pituitary adenomas

Tarasova Tatiana , Pigarova Ekaterina , Dzeranova Larisa , Tulpakov Anatoly , Dedov Ivan

Introduction: Most of the work on the analysis of molecular genetic defects in pituitary adenomas devoted to the study of 1–2 candidate genes. The high-performance parallel sequencing is more promising.Materials and Methods: There were a total of 26 families (58 patients, 36 (62.1%) men and 22 (37.9%) women) with pituitary adenomas secretion of various types. The number of families with homogenous type was 17 (somatotropinomas 13, prolactinomas 2, c...

ea0041ep749 | Neuroendocrinology | ECE2016

Molecular genetic analysis in familial isolated pituitary adenoma patients

Pigarova Ekaterina , Tarasova Tatiana , Mamedova Elizaveta , Dalantaeva Nadezhda , Tulpakov Anatoliy , Dzeranova Larisa

Introduction: FIPA- is a syndrome which includes pituitary adenomas with any kind of secretion in two or more members in a family in the absence of MEN or Carney complex; it also includes isolated family somatotropin syndrome (IFS).Aim: Molecular genetic study of a gene panel in FIPA patient.Materials and methods: Study included 1 family (2 men, 24 and 58 years) with pituitary adenomas with homogeneous secretion type — somatot...

ea0056ep117 | Pituitary and Neuroendocrinology | ECE2018

GH/TSH secreting adenoma: a clinical case report: GH/TSH secreting adenoma: a clinical case report

Tarasova Tatiana , Lutsenko Alexander , Przhiyalkovskaya Elena , Pigarova Ekaterina , Dzeranova Larisa , Tiulpakov Anatoly , Dedov Ivan

Case description: A 26-year-old female visited an endocrinologist for the first time in 2014 with complaint of neck swelling. Lab results revealed increased blood level of TSH, initially the diagnosis of hypothyroidism was set and levothyroxine therapy was initiated with consequent addition of thiamazole due to increasing levels of free T4 and TSH. In 2015 the diagnosis of TSH-secreting adenoma was made on the basis of MRI findings (pituitary microadenoma 3.1 mm in size) and l...