Searchable abstracts of presentations at key conferences in endocrinology

ea0059s8.2 | Thyroid in pregnancy | SFEBES2018

CATS Obstetric and development – implications for thyroid screening in pregnancy

Taylor Peter

Low thyroid function in pregnancy is associated with adverse obstetric outcomes but it is unclear whether screening and initiation of levothyroxine during pregnancy is beneficial. The Controlled Antenatal Thyroid Study (CATS) was a randomised controlled trial which screened women for low thyroid function (subclinical hypothyroidism and isolated hypothyroxinemia) between 11 and 16 weeks gestation. CATS provides data on obstetric outcomes and offspring neurological development. ...

ea0065p408 | Thyroid | SFEBES2019

Weight trajectory during treatment for hyperthyroidism

Dicasillati Gaia Alhena , Taylor Peter

Objectives: Hyperthyroidism is associated with a high basal metabolic rate and weight loss is a common symptom. However, it has been observed, that once patients are treated, they gain back the lost weight and may also put on more. Given that weight gain is a health factor, there’s interest in studying the effect that the thyroid levels have on weight gain and potential harmful health consequences.Methods: 79 patients (58 female) with hyperthyroidis...

ea0082we5 | Workshop E: Disorders of the gonads | SFEEU2022

A challenging case of hypogonadism

Lei Yin Win , Witczak Justyna , Taylor Peter

Gonadal dysgenesis with DAX1 duplication as the cause of XY disorder of sexual development is a rare condition. Duplication of this causes male to female sex reversal while mutation or deletion can cause adrenal hypoplasia congenita with hypogonadotropic hypogonadism. We present a case of 37-year-old lady who was referred to endocrine clinic with ongoing symptoms of fatigue. She was diagnosed with 46 XY gonadal dysgenesis when she presented with groin swelling at the ...

ea0015p380 | Thyroid | SFEBES2008

A role for 3-iodothyronamine in regulation of adipocyte lipolysis

Mitchell Fiona , Scanlan Thomas , Taylor Peter

Iodothyronamines are endogenous trace amines which are putative products of thyroid hormone decarboxylation by Aromatic Amino acid Decarboxylase (AADC). 3-Iodothyronamine (T1AM) has been shown to have profound effects on rodents in vivo, including reductions in body temperature, blood pressure and cardiac output, alongside a switch from carbohydrate to fat utilisation. It is possible that T1AM induces some of these effec...

ea0050oc2.2 | Clinical Highlights | SFEBES2017

Combined immunosuppression & radiotherapy in thyroid eye disease (CIRTED) trial: A multi-centre, double-masked, factorial randomised controlled trial

Taylor Peter , Rajendram Rathie , Uddin Jimmy , Lee Richard , Dayan Colin

On behalf of the Combined immunosuppression & radiotherapy in thyroid eye disease (CIRTED) InvestigatorsBackground: Thyroid eye disease is an inflammatory orbital condition which causes visual dysfunction and psychological morbidity. Current evidence is conflicting on the benefit of radiotherapy and antiproliferative immunosuppression in addition to systemic corticosteroid treatment. In particular, little is known about clinical outcomes mor...

ea0050oc2.2 | Clinical Highlights | SFEBES2017

Combined immunosuppression & radiotherapy in thyroid eye disease (CIRTED) trial: A multi-centre, double-masked, factorial randomised controlled trial

Taylor Peter , Rajendram Rathie , Uddin Jimmy , Lee Richard , Dayan Colin

On behalf of the Combined immunosuppression & radiotherapy in thyroid eye disease (CIRTED) InvestigatorsBackground: Thyroid eye disease is an inflammatory orbital condition which causes visual dysfunction and psychological morbidity. Current evidence is conflicting on the benefit of radiotherapy and antiproliferative immunosuppression in addition to systemic corticosteroid treatment. In particular, little is known about clinical outcomes mor...

ea0059oc1.3 | Translational highlights | SFEBES2018

Novel insights into the genetic architecture of thyroid disease

Taylor Peter , Anney Richard , Dayan Colin , Ludgate Marian , Rees Aled

Introduction: There has been a substantial increase in our knowledge of the genetic architecture of thyroid function, with numerous variants associated with TSH and/or FT4 levels. However, our knowledge of the genetic variants associated with thyroid disease is more limited.Methods: Data was obtained from the Neale laboratory† which provided a case-control study to identify single nucleotide polymorphisms associated with a diagnosis of hypothyroidi...

ea0077op1.1 | Thyroid | SFEBES2021

Factors predicting long-term outcome and the need for surgery in Graves Orbitopathy extended follow-up from the CIRTED Trial

Taylor Peter , Rajendty -45tyram Rathie , Uddin Jimmy , Lee Richard , Dayan Colin

Context: Thyroid eye disease is disabling and disfiguring and has a substantial negative impact on quality of life. Medical therapies to reduce inflammation are widely used, but there is limited data from clinical trials beyond 6 months of follow-up. Methods: 3 year follow-up of a subset of the CIRTED trial (n = 68) which randomized patients to receive high-dose oral steroid with azathioprine/placebo and radiotherapy/sham radiotherapy. We compar...

ea0044ep47 | (1) | SFEBES2016

Hyperosmolar Hyperglycaemic state following Diazoxide therapy for Insulinoma

Tabasum Arshiya , Taylor Peter , Dacruz Thomas , Kang Katherine , Wenike-Briggs Mina , Jenkins Katie , Bolusani Hemanth

A 67-year-old lady was admitted through her General Practitioner with a history of reduced oral intake & unresponsiveness. She was diagnosed to have an insulinoma in 2012 and has been on diazoxide 75 mg thrice daily as she was deemed to be unfit for any surgical intervention. On clinical examination, she was pyrexial, tachycardic, hypoxic and had an initial GCS of 3. She was noted to have shingles on her chest & right basal coarse crackles.On adm...

ea0025oc1.8 | Young Endocrinologists prize session | SFEBES2011

TSH levels and thyroid hormone prescribing in primary care in the UK

Iqbal Ahmed , Taylor Peter , Panicker Vijay , Sayers Adrian , Greenwood Rosemary , Mukhtar Rasha , Evans Jonathan , Dayan Colin

Objective: Hypothyroidism is common and predominantly managed in primary care. Symptoms are non-specific, with thyroid function tests (TFT) required for diagnosis. We sought to investigate current practice in levothyroxine prescribing in primary care.Methods: We studied the initiation of levothyroxine using the General Practice Research Database (GPRD), the world’s largest database of anonymised medical records. Individuals with i) thyroid cancer ii...