Endocrine Abstracts

Introduction: Although data on the association of primary hyperparathyroidism (pHPT) with cardiovascular disease are accumulating, there is still controversy on this issue. Moreover, possible associations of aortic stiffness and central aortic pressures with pHPT and associated effective molecules have not been addressed.Methods: Seventy patients with pHPT were consecutively recruited from the outpatients’ clinic of an academic department of endocri...

Purpose: High serum homocysteine (HCY) and indirectly deficiency of folate and/or vitamin B12 stimulate bone resorption and adversely affect collagen cross-linking. The aim of this study was the evaluation of serum levels of HCY, folate and vitamin B12 in patients with Paget’s disease of bone (PDB) and the effect of zoledronic acid (ZOL) on their serum levels.Methods: This was a prospective open-label cohort study, with a control arm at baseline. Ni...

ObjectivesHigh-Dose-Intravenous-Steroid-Treatment-(HDIST) represents the first choice of treatment for MS relapses. Although chronic oral GC-administration is associated with bone loss there are still conflicting data regarding HDIST. Methods25 newly-diagnosed MS-patients (10-women) were prospectively enrolled meeting the following eligibility criteria: age 18–45 yrs, fully ambulatory, women with normal ...

Background: This is the first study, that aimed: a) to compare immune response, namely the kinetics of neutralizing antibodies (Nabs), after vaccination with BNT162b2 mRNA vaccine between patients with autoimmune thyroiditis and controls, and b) to investigate changes in thyroid function in healthy subjects with no history of thyroid dysfunction before and after vaccination.Methods: The entire study consisted of two sub-studies. In the first sub-study, N...