Endocrine Abstracts

Introduction: Polycystic ovary syndrome (PCOS) is the most prevalent endocrine and metabolic disorder of women of reproductive age. Comprehensive metabolic profiling of women with PCOS across different ethnicities will help in understanding the pathophysiology of this condition.Methods: The Born in Bradford (BiB) study is a UK longitudinal birth cohort. Profiling of circulating lipids, fatty acids, and metabolites was do...

Introduction: Glycoprotein Acetyls (GlycA), is a marker of systemic inflammation, we have recently shown its association with pregnancy in Polycystic Ovary Syndrome (PCOS). This study aims to investigate the association between GlycA levels and the risk of gestational diabetes mellitus (GDM) and preeclampsia in the Born in Bradford (BiB) cohort.Methods: The Born in Bradford study is a UK-based longitudinal birth cohort. We performed profiling of circulat...

Background: Hyponatraemia is the most common electrolyte disorder seen in clinical practice. Even mild hyponatraemia can lead to gait disturbances and cognitive dysfunction in the elderly.Case history: A 83-year-old lady presented to acute admission unit with worsening of confusion. Her background medical history includes chronic obstructive pulmonary disease for which she is on inhalers. She was also having hyponatraemia for the last 3 years manifesting...

Case history: A 54-year-old lady was diagnosed with primary hypoparathyroidism in 2006, after being referred by her Rheumatologist as her father and brother had familial hypoparathyroidism and sensorineural deafness. She was followed up in endocrine clinic for management of primary hypoparathyroidism. Her hypocalcaemia is well managed with calcium supplementation, with no specific symptoms of hypocalcaemia. She has recurrent urinary tract infections with known borderline chro...

Background: We used Mendelian randomization and machine learning (gradient boosting) to assess the causal association of Type 2 Diabetes with osteoporosis.Methods: We selected 155 SNPs associated with type 2 diabetes and glycaemic and insulin-related traits reported in previous studies (1,2) and studied the association with Heel bone mineral density (BMD)) (n= 4 72 996) and risk of fragility fractures (26 157 cases and 17 807 controls) in UKBiob...

Context: Exogenous oestrogen administration causes prolactinoma formation in rats and there are anecdotal reports of oestrogen treatment and prolactinoma formation in gender reassignment males to females. It remains unclear whether chronic exposure to high dose oestrogen in women is linked with prolactinoma development.Aim: The aim of this study was to determine the effect of high dose subcutaneous estrogen on prolactin and gonadotrophin levels of 101 wo...

Functioning adrenal masses are often a diagnostic challenge and can present with unusual symptoms. We describe a case of a 37-year-old male with a background of ulcerative colitis, who presented with gynecomastia in the breast clinic. His serumbiochemistry showed persistently elevated Oestradiol and prolactin, with low testosterone and FSH. On physical examination, he had marked breast tenderness, bilateral gynecomastia and no signs of steroid excess. He reported a decline in ...

Background: Polycystic ovary syndrome (PCOS) is believed to be a primeval condition with the earliest hints of its existence found in ancient Egyptian literature. Despite its negative impact on fertility, it has emerged as the most common endocrine disorder in women of reproductive age, creating what is called the PCOS paradox. We hypothesized that this phenomenon can be explained by testosterone-mediated high bone mineral density (BMD) in women with PCOS, providing a survival...

Case History: This 19-year-old Caucasian female was seen in the Endocrine clinic with history of primary amenorrhea. She had a low sexual drive, no breast development but reported presence of axillary and pubic hair growth. Her main concern was whether she would be able to conceive. She had no comorbidities and took no regular medications. She never smoked and consumed no alcohol. On examination, she was 171 cm tall with a weight of 65.5 kg. She had normal external female geni...

Case history: Adrenal masses are often a diagnostic challenge and can present with unusual symptoms. We describe a case of a 37-year-old male with a background of ulcerative colitis, who presented with bilateral gynecomastia in the breast clinic of, worsening over last one year. He had marked breast tenderness, a decline in his libido but no erectile dysfunction. There was no history of recreational drug use.Investigations: His serum biochemistry showed ...